Members

David BENOIST

Associate Professor

Email : [email protected]
ORCID : 0000-0002-7159-3451

Professional background

2025-now: Head of the Pathophysiology Department, Electrophysiology and Heart Modeling Institute (IHU Liryc), Bordeaux
2021-now: Head of teaching for the international MSc “Electromechanical Heart Diseases”, University of Bordeaux
2018-now: Associate Professor, Inserm U1045 CRCTB, IHU Liryc, University of Bordeaux.
2017-2018: Liryc research associate, Inserm U1045 CRCTB, IHU Liryc, University of Bordeaux.
2011-2017: Post-doctoral researcher, Inserm U1045 CRCTB, IHU Liryc, University of Bordeaux.
2007-2011: PhD student, Institute of Membrane and Systems Biology, University of Leeds (UK).

Funding

• Interdisciplinary and exploratory research grant from the University of Bordeaux (2025-2027): Identifiying pathogenic auto-immunity in cardiac arrhythmias. Co-PI : 78k€
• Project grant from Fédération Française de Cardiologie (2023-2025): Role of TREK-1 in right ventricular mechano-electric coupling and arrhythmogenicity. PI: 50k€.
• ANR Collaborative research project (2023-2027): Ventricular scar-mediated arrhythmogenesis. Co-PI: 118k€
• IHU Liryc 2021 internal call for collaborative translational research: Characterization of the right ventricular electrophysiological remodelling in rats with a BMPR2 mutation and pulmonary hypertension. 2021-2022. Co-PI : 30 k€.
• ANR young investigator research grant: Mechano-electric coupling in the healthy and pressure-overloaded right ventricular outflow tract. 2019-2023. PI : 298k€

Publications 20

January 2025 Biorxiv

AI-based identification of cardiac Purkinje fiber cells isolated from whole adult sheep hearts

Authors : Chaigne, S., Hof, T., Mimoun, K., Ghebouli, A.E., Charron, S., Brette, F., Choveau, F., Pasdois, P., Rucker-Martin, C., Benoist, D., Guinamard, R., Haissaguerre, M., Walton, R., Bernus, O.
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January 2024 Arteriosclerosis, Thrombosis, and Vascular Biology

Thrombosis in the Coronary Microvasculature Impairs Cardiac Relaxation and Induces Diastolic Dysfunction

Authors : Paul Rouault, Sarah Guimbal, Lauriane Cornuault, Célia Bourguignon, Ninon Foussard, Philippe Alzieu, Frank Choveau, David Benoist, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Marie-Ange Renault
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January 2024 Jacc Clinical Electrophysiology

Distinct Electrogram Features and Ventricular Arrhythmia Induction Modes Between Repolarization and Conduction Heterogeneities

Authors : Renard, E., Surget, E., Walton, R.D., Michel, C., Benoist, D., Dubes, V., Guillot, B., Martinez, M.E., Hocini, M., Haïssaguerre, M., Bernus, O.
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July 2023 British journal of pharmacology

OP2113, a new drug for chronic hypoxia-induced pulmonary hypertension treatment in rat.

Authors : Roubenne L, Laisné M, Benoist D, Campagnac M, Prunet B, Pasdois P, Cardouat G, Ducret T, Quignard JF, Vacher P, Baudrimont I, Marthan R, Berger P, Le Grand B, Freund-Michel V, Guibert C
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June 2023 Cells

Pathophysiological Roles of the TRPV4 Channel in the Heart

Authors : Sébastien Chaigne, Solène Barbeau, Thomas Ducret, Romain Guinamard, David Benoist
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April 2023

Pathophysiological Roles of TRPV4 Channel in the Heart

Authors : Sébastien Chaigne, Solène Barbeau, Thomas Ducret, Romain Guinamard, David Benoist
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January 2023 Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Cardiac structure discontinuities revealed by ex-vivo microstructural characterization. A focus on the basal inferoseptal left ventricle region

Authors : Cabanis P, Magat J, Rodriguez-Padilla J, Ramlugun G, Yon M, Bihan-Poudec Y, Pallares-Lupon N, Vaillant F, Pasdois P, Jais P, Dos-Santos P, Ozenne V
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January 2023 Jacc Clinical Electrophysiology

Functional Epicardial Conduction Disturbances Due to a SCN5A Variant Associated With Brugada Syndrome

Authors : Renard, E., Walton, R.D., Benoist, D., Brette, F., Bru-Mercier, G., Chaigne, S., Charron, S., Constantin, M., Douard, M., Dubes, V., Guillot, B., Hof, T., Magat, J., Martinez, M.E., Michel, C., Pallares-Lupon, N., Pasdois, P., Récalde, A., Vaillant, F., Sacher, F., Labrousse, L., Rogier, J., Kyndt, F., Baudic, M., Schott, J.-J., Barc, J., Probst, V., Sarlandie, M., Marionneau, C., Ashton, J.L., Hocini, M., Haïssaguerre, M., Bernus, O.
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January 2023 Biomolecules

Characterization of Experimentally Observed Complex Interplay between Pulse Duration, Electrical Field Strength, and Cell Orientation on Electroporation Outcome Using a Time-Dependent Nonlinear Numerical Model

Authors : Scuderi, M., Dermol-Černe, J., Batista Napotnik, T., Chaigne, S., Bernus, O., Benoist, D., Sigg, D.C., Rems, L., Miklavčič, D.
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November 2022 Circulation: Arrhythmia and Electrophysiology

Reversible and Irreversible Effects of Electroporation on Contractility and Calcium Homeostasis in Isolated Cardiac Ventricular Myocytes

Authors : Sébastien Chaigne, Daniel C. Sigg, Mark T. Stewart, Mélèze Hocini, Tina Batista Napotnik, Damijan Miklavčič, Olivier Bernus, David Benoist
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April 2022 Journal of imaging

Spiky: An ImageJ Plugin for Data Analysis of Functional Cardiac and Cardiomyocyte Studies.

Authors : Pasqualin C, Gannier F, Yu A, Benoist D, Findlay I, Bordy R, Bredeloux P, Maupoil V
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June 2021 PLOS Computational Biology

A computational model of pig ventricular cardiomyocyte electrophysiology and calcium handling: Translation from pig to human electrophysiology

Authors : Namit Gaur, Daniel A. Beard, Xiao-Yan Qi, David Benoist, Olivier Bernus, Ruben Coronel, Stanley Nattel, Edward J. Vigmond
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July 2018 Journal of Molecular and Cellular Cardiology

Beta1-adrenoceptor antagonist, metoprolol attenuates cardiac myocyte Ca2+ handling dysfunction in rats with pulmonary artery hypertension

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January 2017 WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY

Unexpected Internalization of a Pulmonary Artery Band in a Porcine Model of Tetralogy of Fallot

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September 2015 Journal of Molecular and Cellular Cardiology

Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension

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August 2014 Molecular and Cellular Biochemistry

Lipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology

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March 2013 Journal of Molecular and Cellular Cardiology

Microtubule proliferation in right ventricular myocytes of rats with monocrotaline-induced pulmonary hypertension

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January 2012 American Journal of Physiology-Heart and Circulatory Physiology

Regional skeletal muscle remodeling and mitochondrial dysfunction in right ventricular heart failure

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July 2010 British Journal of Pharmacology

Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current

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June 2008 Progress in Biophysics and Molecular Biology

Inhomogeneity in the response to mechanical stimulation: Cardiac muscle function and gene expression

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Team

Team 3

Cardiac electrophysiology

Specializing in the study and treatment of fibrillatory arrhythmias and dyssynchrony, this team has advanced expertise in rhythmology, experimental electrophysiology, signal processing, and clinical imaging.

Leadership : Olivier BERNUS