Fabien BEAUFILS

Associate Professor- Hospital Practioner

Professional background

Since 2025 Head of the Pediatric Asthma hospitalization Unit, Bordeaux University Hospital (CHU de Bordeaux)

Since 2025 Associate Professor of Physiology & Attending Physician, University of Bordeaux & Bordeaux University Hospital, INSERM U1045, Pulmonary Function Testing Unit

2023 – 2024 Postdoctoral Fellow, Prof. Philip Hansbro’s team, Centre for Inflammation, Centenary Institute, Sydney (NSW, Australia) & University of Technology Sydney, School of Life Sciences

2022 – 2025 Academic Hospital Physician in Physiology, University of Bordeaux & Bordeaux University Hospital

2020 Habilitation in Allergology and Clinical Immunology

2018 – 2021 PhD in Cellular Biology and Pathophysiology, INSERM U1035, University of Bordeaux

2018 – 2022 Assistant Professor in Physiology, University of Bordeaux & Bordeaux University Hospital

2018 – Habilitation in Pediatric Pulmonology

2013 – 2018 Medical residency in Pediatrics

Funding

Grants as Principal investigator

ANR – PRC, 2025–2030 (ICEBERG, €704k) : Identification of predictive biomarkers and pathophysiological mechanisms of BR1 and BR2, the two novel bronchial remodeling–based endotypes of severe preschool wheezers

Fondation Bordeaux Université – Fonds pour les Maladies Chroniques, 2023 (€50k) –Mobility Award – Role of maternal smoking and early-life infection in the pathogenesis of COPD in the offspring

CHU de Bordeaux, 2023 (€15k) – Mobility Grant – Role of maternal smoking and early-life infection in the pathogenesis of COPD in the offspring

Fondation Bordeaux Université – Fonds pour les Maladies Chroniques (€19k): Mechanisms involved in bronchial remodeling in children with asthma

CHU de Bordeaux – Internal Call for Proposals, 2020 (ARISE, €60k): Analysis of bronchial remodeling using magnetic resonance imaging in children with asthma

French Society of Pediatric Pulmonology and Allergology & AstraZeneca (€16k) – Mobility Award – Effect of azithromycin on bronchial smooth muscle cell proliferation in preschool wheezers

Members

Fabien BEAUFILS

Professional background

Funding

Publications 27

Quantitative CT Evaluation of Bronchiectasis Improvement in Cystic Fibrosis after CFTR-Modulator Therapy

Validity and reliability of anharmonic morphological ventilometry for the characterisation of human breathing

Bronchial smooth muscle extracellular vesicles interfere with bronchial epithelium metabolism and function in asthma

Predicting exacerbations in severe preschool wheezers

Airway bacterial colonization is associated with bronchial remodeling in severe preschool wheezers

Commentary: Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration

Home‐spirometry exacerbation profiles in children with cystic fibrosis

Dietary intake assessment in children with cystic fibrosis using 3-day food diaries: a single-centre study

Nutritional impact of CFTR modulators in children with cystic fibrosis

Adherence, reliability, and variability of home spirometry telemonitoring in cystic fibrosis

Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor

Increased airway smooth muscle cells in asthma: mechanisms and therapeutic prospects

Cellular and molecular mechanisms of NiONPs toxicity on eel hepatocytes HEPA-E1: An illustration of the impact of Ni release from mining activity in New Caledonia

Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction

Rhinovirus infection of bronchial epithelium induces specific bronchial smooth muscle cell migration of severe asthmatic patients

European Respiratory Society International Congress 2021: highlights from best-abstract awardees

NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption

Circulating fibrocytes as a new tool to predict lung cancer progression after surgery?

Long-Term Outcomes in Real Life of Lumacaftor–Ivacaftor Treatment in Adolescents With Cystic Fibrosis

Respiratory rehabilitation for Covid-19 related persistent dyspnoea: A one-year experience

Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers

The lower respiratory airway wall in children in health and disease

Increased Fecal Calprotectin Is Associated with Worse Gastrointestinal Symptoms and Quality of Life Scores in Children with Cystic Fibrosis

Reduced Intestinal Inflammation With Lumacaftor/Ivacaftor in Adolescents With Cystic Fibrosis

Nursery Assistants’ Performance and Knowledge on Cardiopulmonary Resuscitation: Impact of Simulation-Based Training.

The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks

Bnip3 as a potential target to treat airway smooth muscle remodeling in asthma?

Team

Bronchial remodeling