Guillaume CARDOUAT

Teaching Researcher

Email : [email protected]

ORCID : 0000-0002-2990-8907

Professional background

Since 2021 Associate professor

2020 – 2021 Assistant professor, CRCTB, INSERM U1045, Université de Bordeaux

2018 – 2020 Postdoctoral Researcher, CRCTB, INSERM U1045, Université de Bordeaux

2017 – 2018 Assistant professor, CRCTB, INSERM U1045, Université de Bordeaux

2013 – 2017 PhD, I2MC Inserm U1297 – Institut des maladies métaboliques et cardiovasculaires

Funding

Prematuration (2025)

Publications 17

April 2024 Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity.

Authors : Cardouat G, Douard M, Bouchet C, Roubenne L, Kmecová Z, Esteves P, Brette F, Guignabert C, Tu L, Campagnac M, Robillard P, Coste F, Delcambre F, Thumerel M, Begueret H, Maurac A, Belaroussi Y, Klimas J, Ducret T, Quignard JF, Vacher P, Baudrimont I, Marthan R, Berger P, Guibert C, Freund-Michel V

July 2023 British Journal of Pharmacology

OP2113, a new drug for chronic hypoxia‐induced pulmonary hypertension treatment in rat

Authors : Lukas Roubenne, Margaux Laisné, David Benoist, Marilyne Campagnac, Bénédicte Prunet, Philippe Pasdois, Guillaume Cardouat, Thomas Ducret, Jean‐François Quignard, Pierre Vacher, Isabelle Baudrimont, Roger Marthan, Patrick Berger, Bruno Le Grand, Véronique Freund‐Michel, Christelle Guibert

September 2022 Cells

Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism

Authors : Clément Bouchet, Guillaume Cardouat, Matthieu Douard, Florence Coste, Paul Robillard, Frédéric Delcambre, Thomas Ducret, Jean-François Quignard, Pierre Vacher, Isabelle Baudrimont, Roger Marthan, Patrick Berger, Christelle Guibert, Véronique Freund-Michel

July 2022 Cells

Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca2+ Influx and Akt-eNOS Pathway

Authors : Thais Porto Ribeiro, Solène Barbeau, Isabelle Baudrimont, Pierre Vacher, Véronique Freund-Michel, Guillaume Cardouat, Patrick Berger, Christelle Guibert, Thomas Ducret, Jean-François Quignard

July 2022 Biomolecules

Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia

Authors : Solène Barbeau, Alexandre Joushomme, Yann Chappe, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Patrick Berger, Pierre Vacher, Yann Percherancier, Jean-François Quignard, Thomas Ducret

July 2022 Journal of Allergy and Clinical Immunology

Rhinovirus infection of bronchial epithelium induces specific bronchial smooth muscle cell migration of severe asthmatic patients

Authors : Alexis Celle, Pauline Esteves, Guillaume Cardouat, Fabien Beaufils, Edmée Eyraud, Isabelle Dupin, Elise Maurat, Sabrina Lacomme, Olga Ousova, Hugues Begueret, Matthieu Thumerel, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger, Thomas Trian

April 2022 Antioxidants

NiONP-Induced Oxidative Stress and Mitochondrial Impairment in an In Vitro Pulmonary Vascular Cell Model Mimicking Endothelial Dysfunction

Authors : Ophélie Germande, Thomas Ducret, Jean-Francois Quignard, Juliette Deweirdt, Véronique Freund-Michel, Marie-Hélène Errera, Guillaume Cardouat, Pierre Vacher, Bernard Muller, Patrick Berger, Christelle Guibert, Magalie Baudrimont, Isabelle Baudrimont

February 2022 Revue des Maladies Respiratoires

Implication des canaux mécanosensibles Piezo1 et TRPV4 dans l’hypertension pulmonaire

Authors : S. Barbeau, T. Porto Ribeiro, G. Gilbert, G. Cardouat, I. Baudrimont, V. Freund-Michel, C. Guibert, R. Marthan, P. Vacher, J.-F. Quignard, T. Ducret

January 2022 Frontiers in Pharmacology

Muscarinic receptor M3 activation promotes fibrocytes contraction

Authors : Henrot, P., Eyraud, E., Maurat, E., Point, S., Cardouat, G., Quignard, J.-F., Esteves, P., Trian, T., Girodet, P.-O., Marthan, R., Zysman, M., Berger, P., Dupin, I.

September 2021 Biomolecules

Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension

Authors : Solène Barbeau, Guillaume Gilbert, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Pierre Vacher, Jean-François Quignard, Thomas Ducret

March 2021 American Journal of Physiology-Heart and Circulatory Physiology

Transient receptor potential vanilloid 4 channel participates in mouse ventricular electrical activity

January 2021 European Respiratory Journal

Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling

Authors : Esteves, P., Blanc, L., Celle, A., Dupin, I., Maurat, E., Amoedo, N., Cardouat, G., Ousova, O., Gales, L., Bellvert, F., Begueret, H., Thumerel, M., Dupuy, J.-W., Desbenoit, N., Marthan, R., Girodet, P.-O., Rossignol, R., Berger, P., Trian, T.

March 2020 Revue des Maladies Respiratoires

Expression et rôle du facteur de croissance des nerfs NGF dans l’hypertension pulmonaire

January 2020 American Journal of Physiology-Lung Cellular and Molecular Physiology

TRPV4 channel mediates adventitial fibroblast activation and adventitial remodeling in pulmonary hypertension

Authors : Laure-Anne Cussac, Guillaume Cardouat, Nichiren Tiruchellvam Pillai, Marilyne Campagnac, Paul Robillard, Anaïs Montillaud, Christelle Guibert, Philippe Gailly, Roger Marthan, Jean-François Quignard, Jean-Pierre Savineau, Thomas Ducret

September 2017 Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Ectopic adenine nucleotide translocase activity controls extracellular ADP levels and regulates the F 1 -ATPase-mediated HDL endocytosis pathway on hepatocytes

January 2016 Pflügers Archiv - European Journal of Physiology

Effect of hypoxia on TRPV1 and TRPV4 channels in rat pulmonary arterial smooth muscle cells

September 2012 Pflügers Archiv - European Journal of Physiology

Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells