Members

Olivier BERNUS

Professor / Manager of the team 3

Email : [email protected]
ORCID : 0000-0003-3917-5791

Professional background

2014 – present Professor, Inserm U1045 – Centre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux (France)
2019 – 2023 Deputy Director of the Health Sciences and Technologies Department, Université de Bordeaux (France)
2011 – 2022 Scientific Director of the Electrophysiology and Heart modeling Institute (IHU Liryc), Bordeaux (France)
2011 – 2014 Assistant Professor, Inserm U1045 – Centre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux (France)
2007 – 2011 Tenure-track Independent Research Fellow, Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds (UK)
2004 – 2006 Postdoctoral Research Fellow, Department of Pharmacology, SUNY Upstate Medical University, Syracuse (USA)
1999 – 2003 PhD student, Department of Mathematical Physics and Astronomy, Ghent University (Belgium)

Funding

Funding over the last 5 years:
• Leducq Transatlantic Network of Excellence “Bioelectronics for neurocardiology – Diagnosis and Therapeutics” (2024 – 2029), 1.3M€. Co-Principal Investigator.
• Fondation Bettencourt-Schueller “Localized myocardial alterations at the origin of Sudden
Cardiac Death” (2023-2026) 450k€. Principal Investigator.
• PRC ANR PURKINJENET “Purkinje system remodeling in life-threatening arrhythmias” (2022-
2026), 566k€. Co-Principal Investigator.
• Fédération Française de Cardiologie “ Rôle spécifique des canaux TRPM et des fibres de
Purkinje dans la mort subite” (2022-2023), 50k€. Principal Investigator.
• PRC ANR MAESTRO “Magnetic Signal detection of ventricular arrhythmOgenic substrates”
(2019-2023), 343k€. Collaborator.
• PRC ANR UNMASC “Understanding the remodeling processes during atrial fibrillation
stabilization for improved therapeutics” (2017 – 2022), 405k€. Collaborator.
• Leducq Transatlantic Network of Excellence “RHYTHM: Repolarization HeterogeneitY imaging
for personalised Therapy of Heart ArrhythMia” (2016 – 2022), 1.09M€. Senior Investigator.

Patents

• « Electrode configurations for diagnosis of arrhythmias » Shubhayu Basu, Meir Bar-tal, Mario A. Solis, Michel Haissaguerre, Pierre Jais, Meleze Hocini, Olivier Bernus, Rémi Dubois, Masateru Takigawa. US20240341688A1
• « Method for selecting electrophysiological descriptors » Laura Bear, Olivier Bernus, Rémi Dubois, Michel Haissaguerre, Nolwenn Tan. EP4315352A1
• « Method and device for detecting representative cardiac electrical activity » Laura Bear, Olivier Bernus, Rémi Dubois, Michel Haissaguerre, Nolwenn Tan. EP4312770A1

Publications 207

January 2025 Biorxiv

AI-based identification of cardiac Purkinje fiber cells isolated from whole adult sheep hearts

Authors : Chaigne, S., Hof, T., Mimoun, K., Ghebouli, A.E., Charron, S., Brette, F., Choveau, F., Pasdois, P., Rucker-Martin, C., Benoist, D., Guinamard, R., Haissaguerre, M., Walton, R., Bernus, O.
Read more
January 2025 Ssrn

Resistance to Atrial Fibrillation Domestication and Mitochondrial Dysfunction in Sheep: A Potential Key Role of the Tca Cycle and Mitochondrial Redox State

Authors : Caluori, G., Nattel, S., Pinson, B., Naud, P., Beauvoit, B., Claverol, S., Vaillant, F., Charron, S., Guilloteau, F., Loyer, V., Constantin, M., Popa, M., Belykh, A., Haeberlin, A., Ploux, S., Mahamat, H.A., Dubois, R., Guillot, B., Krisai, P., Kamakura, T., Bernus, O., Jaïs, P., Dos Santos, P., Pasdois, P.
Read more
January 2025 Biorxiv

Resistance to Atrial Fibrillation Domestication and Mitochondrial Dysfunction in Sheep: a potential key role of the TCA Cycle and mitochondrial redox state

Authors : Caluori, G., Nattel, S., Pinson, B., Naud, P., Beauvoit, B., Claverol, S., Vaillant, F., Charron, S., Guilloteau, F., Loyer, V., Constantin, M., Popa, M., Belykh, A., Haeberlin, A., Ploux, S., Mahamat, H.A., Dubois, R., Guillot, B., Krisai, P., Kamakura, T., Bernus, O., Jaïs, P., Santos, P.D., Pasdois, P.
Read more
January 2025 Frontiers in Physiology

Correction: Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation(Front. Physiol., (2023), 14, (1120336), 10.3389/fphys.2023.1120336)

Authors : Guillot, B., Boileve, A., Walton, R., Harfoush, A., Conte, C., Sainte-Marie, Y., Charron, S., Bernus, O., Recalde, A., Sallé, L., Brette, F., Lezoualc’h, F.
Read more
January 2025 Heart Rhythm

Origin of ventricular fibrillation triggers in a model of localized repolarization heterogeneity

Authors : Renard, E., Haïssaguerre, M., Bear, L.R., Bernus, O.
Read more
January 2025 Heart Rhythm

Atrial fibrillation nomenclature, definitions, and mechanisms: Position paper from the international Working Group of the Signal Summit

Authors : de Groot, N.M.S., Kleber, A., Narayan, S.M., Ciaccio, E.J., Doessel, O., Bernus, O., Berenfeld, O., Callans, D., Fedorov, V., Hummel, J., Haissaguerre, M., Natale, A., Trayanova, N., Spector, P., Vigmond, E., Anter, E.
Read more
January 2025 Surgical and Radiologic Anatomy

Anatomy of the oblique vein of the left atrium: contribution of microCT analysis of human hearts

Authors : Delgove, A., Walton, R., Pallares-Lupon, N., Ozenne, V., Constantin, M., Arnaud, M., Le Quilliec, E., Haïssaguerre, M., Hocini, M., Jaïs, P., Derval, N., Pambrun, T., Bernus, O., Duchâteau, J.
Read more
January 2024 EUROPEAN RESPIRATORY JOURNAL

Novel single-lead electrocardiogram-derived respiratory rate estimation in children with obstructive sleep apnea

Authors :
Read more
January 2024 BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE

Atrial fibrillation and ventricular fibrillation: Similarities and differences

Authors :
Read more
January 2024 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS

Influence of Sex, Age and Body Mass Index on an Algorithm for Electrocardiogram-derived Respiratory Rate

Authors : Adli, A., Nichols, J.H., Roberts, J.D., Bernus, O., Walton, R.D., Kulkarni, K.
Read more
January 2024 Scientific Reports

Open-source software for respiratory rate estimation using single-lead electrocardiograms

Authors : Roberts, J.D., Walton, R.D., Loyer, V., Bernus, O., Kulkarni, K.
Read more
January 2024 Plos One

The Ithildin library for efficient numerical solution of anisotropic reaction-diffusion problems in excitable media

Authors : Kabus, D., Cloet, M., Zemlin, C., Bernus, O., Dierckx, H.
Read more
January 2024 Jacc Clinical Electrophysiology

Distinct Electrogram Features and Ventricular Arrhythmia Induction Modes Between Repolarization and Conduction Heterogeneities

Authors : Renard, E., Surget, E., Walton, R.D., Michel, C., Benoist, D., Dubes, V., Guillot, B., Martinez, M.E., Hocini, M., Haïssaguerre, M., Bernus, O.
Read more
January 2024 Jacc Clinical Electrophysiology

Electrophysiological Characteristics Associated With Spontaneous Termination of Ventricular Fibrillation

Authors : Monaco, C., Cheniti, G., Benali, K., Duchateau, J., Vlachos, K., Sacher, F., Ploux, S., Vigmond, E., Bernus, O., Haïssaguerre, M.
Read more
January 2024 Biorxiv

The Ithildin library for efficient numerical solution of anisotropic reaction-diffusion problems in excitable media

Authors : Kabus, D., Cloet, M., Zemlin, C., Bernus, O., Dierckx, H.
Read more
January 2024 Jacc Clinical Electrophysiology

Distinct Substrates of Idiopathic Ventricular Fibrillation Revealed by Arrhythmia Characteristics on Implantable Cardioverter-Defibrillator

Authors : Haïssaguerre, M., Sellal, J.-M., Benali, K., de Becker, B., Defaye, P., Pascale, P., Martins, R., Mabo, P., Xhaet, O., Extramiana, F., Surget, E., Lavergne, T., Marijon, E., Adragao, P., Carvalho, M.S., Milliez, P.-U., Laredo, M., Gandjbakhch, E., Giustetto, C., Gaita, F., Tilz, R., Jesel-Morel, L., Steinfurt, J., Arentz, T., Knecht, S., Duytschaever, M., Roten, L., Reichlin, T., Fatemi, M., Mansourati, J., Kouakam, C., Bessière, F., Chevalier, P., Tadros, R., Macle, L., Gallego, F., Hadjis, A., Sacher, F., Pereira, D., Hourdain, J., Deharo, J.-C., Eschalier, R., Massoulié, G., Maury, P., Latcu, D.G., Anselme, F., Duchateau, J., Tixier, R., Nademanee, K., Nogami, A., de Groot, N., Vigmond, E., Bernus, O., Strik, M., Bordachar, P., Cathala, A., Bouteiller, X., Dubois, R., Ploux, S.
Read more
January 2023 CIRCULATION

Altered Autonomic Balance Linked to Arrhythmogenicity in Chronic Myocardial Infarction Ovine Model

Authors :
Read more
January 2023 Frontiers in Physiology

Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation

Authors : Guillot, B., Boileve, A., Walton, R., Harfoush, A., Conte, C., Sainte-Marie, Y., Charron, S., Bernus, O., Recalde, A., Sallé, L., Brette, F., Lezoualc’h, F.
Read more
January 2023 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS

Can Stochastic Pacing Restore Heart Rate Variability in Diseased Hearts? An In-vivo Ovine Case Study

Authors : Kulkarni, K., Pallares-Lupon, N., Bernus, O., Walton, R.D.
Read more
January 2023 Plos One

Assessment of Nit-Occlud atrial septal defect occluder device healing process using microcomputed tomography imaging

Authors : Perdreau, E., Jalal, Z., Walton, R.D., Sigler, M., Cochet, H., Naulin, J., Quesson, B., Bernus, O., Thambo, J.-B.
Read more
January 2023 Biomolecules

Characterization of Experimentally Observed Complex Interplay between Pulse Duration, Electrical Field Strength, and Cell Orientation on Electroporation Outcome Using a Time-Dependent Nonlinear Numerical Model

Authors : Scuderi, M., Dermol-Černe, J., Batista Napotnik, T., Chaigne, S., Bernus, O., Benoist, D., Sigg, D.C., Rems, L., Miklavčič, D.
Read more
January 2023 Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics

Symmetric Multimodal Mapping of Ex Vivo Cardiac Microstructure of Large Mammalian Whole Hearts for Volumetric Comparison of Myofiber Orientation Estimated from Diffusion MRI and MicroCT

Authors : Ozenne, V., Ramlugun, G., Magat, J., Lupon, N.P., Cabanis, P., Dos Santos, P., Benoist, D., Dubes, V., Duchateau, J., Labrousse, L., Haïssaguerre, M., Bernus, O., Walton, R.
Read more
January 2023 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS

Image-Based Tools and Analysis for Human RVOT/RV Structures

Authors : Trew, M.L., Sands, G.B., Yang, Z., Ashton, J.L., Vigneshwaran, V., Walton, R.D., Bernus, O., Smaill, B.H.
Read more
January 2023 Frontiers in Physiology

Attenuation of stretch-induced arrhythmias following chemical ablation of Purkinje fibres, in isolated rabbit hearts

Authors : Hurley, M., Walton, R., Vigmond, E.J., Haïssaguerre, M., Bernus, O., White, E.
Read more
January 2023 Journal of Cardiovascular Magnetic Resonance

Cardiac structure discontinuities revealed by ex-vivo microstructural characterization. A focus on the basal inferoseptal left ventricle region

Authors : Cabanis, P., Magat, J., Rodriguez-Padilla, J., Ramlugun, G., Yon, M., Bihan-Poudec, Y., Pallares-Lupon, N., Vaillant, F., Pasdois, P., Jais, P., Dos-Santos, P., Constantin, M., Benoist, D., Pourtau, L., Dubes, V., Rogier, J., Labrousse, L., Haissaguerre, M., Bernus, O., Quesson, B., Walton, R., Duchateau, J., Vigmond, E., Ozenne, V.
Read more
January 2023 Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics

Characterization of the Septal Discontinuity in Ex-Vivo Human Hearts Using Diffusion Tensor Imaging: The Potential Structural Determinism Played by Fiber Orientation in Clinical Phenotype of Laminopathy Patients

Authors : Cabanis, P., Magat, J., Ramlugun, G., Pallares-Lupon, N., Vaillant, F., Abell, E., Bear, L., Michel, C., Pasdois, P., Dos-Santos, P., Constantin, M., Benoist, D., Pourtau, L., Dubes, V., Rogier, J., Labrousse, L., Pernot, M., Busuttil, O., Haissaguerre, M., Bernus, O., Quesson, B., Vigmond, E., Walton, R., Duchateau, J., Ozenne, V.
Read more
January 2023 Frontiers in Physiology

A comprehensive framework for evaluation of high pacing frequency and arrhythmic optical mapping signals

Authors : Ramlugun, G.S., Kulkarni, K., Pallares-Lupon, N., Boukens, B.J., Efimov, I.R., Vigmond, E.J., Bernus, O., Walton, R.D.
Read more
January 2023 Circulation

Inducibility of Short-Coupled Purkinje Ectopy by Pharmacological Tests in Patients With Spontaneous Short-Coupled Idiopathic Ventricular Fibrillation

Authors : Haissaguerre, M., Duchateau, J., Laredo, M., Lavergne, T., Winum, P.F., Cheniti, G., Waintraub, X., Samson, S., Surget, E., Tixier, R., Sacher, F., Marijon, E., Bernus, O., Gandjbakhch, E.
Read more
January 2023 Jacc Clinical Electrophysiology

Left Ventricular Abnormal Substrate in Brugada Syndrome

Authors : Cheniti, G., Haissaguerre, M., Dina, C., Kamakura, T., Duchateau, J., Sacher, F., Racine, H.-P., Surget, E., Simonet, F., Gourraud, J.-B., Sridi, S., Cochet, H., Andre, C., Bouyer, B., Chauvel, R., Tixier, R., Derval, N., Pambrun, T., Dubois, R., Jais, P., Nademanee, K., Redon, R., Schott, J.-J., Probst, V., Hocini, M., Barc, J., Bernus, O.
Read more
January 2023 Biorxiv

Increased spontaneous Ca2+ activity in Cardiac Purkinje cells after myocardial infarction; A consequence of a dramatic shift of SERCA isoforms as potential adaptation to acute ischemia?

Authors : Stuyvers, B.D., Boyden, P.A., Amin, R., Wiede, L., Doré, J., ter Keurs, H.E.D.J., Dun, W., Guo, Y., Haissaguerre, M., Hocini, M., Brette, F., Bernus, O., Chaigne, S., Loyer, V., Naulin, J., Quesson, B., Alafiatayo, A., Benoukraf, T.
Read more
January 2023 Jacc Clinical Electrophysiology

Functional Epicardial Conduction Disturbances Due to a SCN5A Variant Associated With Brugada Syndrome

Authors : Renard, E., Walton, R.D., Benoist, D., Brette, F., Bru-Mercier, G., Chaigne, S., Charron, S., Constantin, M., Douard, M., Dubes, V., Guillot, B., Hof, T., Magat, J., Martinez, M.E., Michel, C., Pallares-Lupon, N., Pasdois, P., Récalde, A., Vaillant, F., Sacher, F., Labrousse, L., Rogier, J., Kyndt, F., Baudic, M., Schott, J.-J., Barc, J., Probst, V., Sarlandie, M., Marionneau, C., Ashton, J.L., Hocini, M., Haïssaguerre, M., Bernus, O.
Read more
January 2023 Jacc Clinical Electrophysiology

Reply: The Mechanism of Brugada Syndrome: Is it Induced Only by Conduction Disturbance?

Authors : Renard, E., Haïssaguerre, M., Bernus, O.
Read more
January 2023 Current Research in Physiology

Endocardial role in arrhythmias induced by acute ventricular stretch and the involvement of Purkinje fibres, in isolated rat hearts

Authors : Hurley, M., Kaur, S., Walton, R., Power, A., Haïssaguerre, M., Bernus, O., Ward, M.-L., White, E.
Read more
January 2023 International Journal of Molecular Sciences

Regional Differences in Ca2+ Signaling and Transverse-Tubules across Left Atrium from Adult Sheep

Authors : Cros, C., Douard, M., Chaigne, S., Pasqualin, C., Bru-Mercier, G., Recalde, A., Pascarel-Auclerc, C., Hof, T., Haïssaguerre, M., Hocini, M., Jaïs, P., Bernus, O., Brette, F.
Read more
November 2022 Circulation: Arrhythmia and Electrophysiology

Reversible and Irreversible Effects of Electroporation on Contractility and Calcium Homeostasis in Isolated Cardiac Ventricular Myocytes

Authors : Sébastien Chaigne, Daniel C. Sigg, Mark T. Stewart, Mélèze Hocini, Tina Batista Napotnik, Damijan Miklavčič, Olivier Bernus, David Benoist
Read more
January 2022 PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

It’s clearly the heart! Optical transparency, cardiac tissue imaging, and computer modelling

Authors :
Read more
January 2022 HEART RHYTHM

Low-energy, single-pulse surface stimulation defibrillates large mammalian ventricles

Authors :
Read more
January 2022 HEART RHYTHM

Multisite conduction block in the epicardial substrate of Brugada syndrome

Authors :
Read more
January 2022 HEART RHYTHM

Reply to the Editor-Give to Caesar what belongs to Caesar

Authors :
Read more
January 2022 ACTA PHYSIOLOGICA

Contribution of Endocardial Purkinje Fibres to Arrhythmias upon Acute Ventricular Dilation in Isolated Rat and Rabbit Hearts

Authors :
Read more
January 2022 BIOPHYSICAL JOURNAL

Involvement of the purkinje fibres in the development of ventricular arrhythmias upon mechanical stimulation

Authors :
Read more
January 2022 Heart Rhythm

Malignant Purkinje ectopy induced by sodium channel blockers

Authors : Escande, W., Gourraud, J.-B., Haissaguerre, M., Gandjbakhch, E., Lavergne, T., Martins, R., Cheniti, G., Krisai, P., Hermida, J.S., Maury, P., Merino, J.-L., Pasquié, J.-L., Combes, N., Surget, E., Duchateau, J., Pambrun, T., Derval, N., Hocini, M., Jaïs, P., Postema, P.G., Nademanee, K., Vigmond, E., Bernus, O., Sacher, F., Probst, V.
Read more
January 2022 Heart Rhythm

Reply to the Editor— Give to Caesar what belongs to Caesar

Authors : Haissaguerre, M., Escande, W., Gourraud, J.-B., Bernus, O., Sacher, F.
Read more
January 2022 Heart Rhythm

Dependence of epicardial T-wave on local activation voltage in Brugada syndrome

Authors : Haissaguerre, M., Cheniti, G., Nademanee, K., Sacher, F., Duchateau, J., Coronel, R., Vigmond, E., Boukens, B.J., Bernus, O.
Read more
January 2022 Biomedical Physics and Engineering Express

In vitro differentiation of human cardiac fibroblasts into myofibroblasts: characterization using electrical impedance

Authors : Degache, A., Poulletier De Gannes, F., Garenne, A., Renom, R., Percherancier, Y., Lagroye, I., Bernus, O., Lewis, N.
Read more
January 2022 European Heart Journal

Purkinje network and myocardial substrate at the onset of human ventricular fibrillation: Implications for catheter ablation

Authors : Haissaguerre, M., Cheniti, G., Hocini, M., Sacher, F., Ramirez, F.D., Cochet, H., Bear, L., Tixier, R., Duchateau, J., Walton, R., Surget, E., Kamakura, T., Marchand, H., Derval, N., Bordachar, P., Ploux, S., Takagi, T., Pambrun, T., Jais, P., Labrousse, L., Strik, M., Ashikaga, H., Calkins, H., Vigmond, E., Nademanee, K., Bernus, O., Dubois, R.
Read more
January 2022 Ssrn

Endocardial Role in Arrhythmias Induced by Acute Ventricular Dilation and the Involvement of Purkinje Fibres, in Isolated Rat Hearts

Authors : Hurley, M., Kaur, S., Walton, R., Power, A., Haïssaguerre, M., Bernus, O., Ward, M.-L., White, E.
Read more
January 2022 American Journal of Physiology Heart and Circulatory Physiology

Impact of intraventricular septal fiber orientation on cardiac electromechanical function

Authors : Rodríguez-Padilla, J., Petras, A., Magat, J., Bayer, J., Bihan-Poudec, Y., El Hamrani, D., Ramlugun, G., Neic, A., Augustin, C.M., Vaillant, F., Constantin, M., Benoist, D., Pourtau, L., Dubes, V., Rogier, J., Labrousse, L., Bernus, O., Quesson, B., Haïssaguerre, M., Gsell, M., Plank, G., Ozenne, V., Vigmond, E.
Read more
January 2022 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS

Investigating Electrophysiological Markers of Arrhythmogenesis in a Chronic Myocardial Infarction Ovine Model

Authors : Kulkarni, K., Pallares-Lupon, N., Armoundas, A.A., Pasdois, P., Bernus, O., Walton, R.D.
Read more
January 2022 Circulation Arrhythmia and Electrophysiology

Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract

Authors : Aras, K., Gams, A., Faye, N.R., Brennan, J., Goldrick, K., Li, J., Zhong, Y., Chiang, C.-H., Smith, E.H., Poston, M.D., Chivers, J., Hanna, P., Mori, S., Ajijola, O.A., Shivkumar, K., Hoover, D.B., Viventi, J., Rogers, J.A., Bernus, O., Efimov, I.R.
Read more
January 2022 Journal of Visualized Experiments

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

Authors : Pallares-Lupon, N., Bayer, J.D., Guillot, B., Caluori, G., Ramlugun, G.S., Kulkarni, K., Loyer, V., Bloquet, S., El Hamrani, D., Naulin, J., Constantin, M., Santos, P.D., Bernus, O., Jaïs, P., Pasdois, P., Walton, R.D.
Read more
June 2021 PLOS Computational Biology

A computational model of pig ventricular cardiomyocyte electrophysiology and calcium handling: Translation from pig to human electrophysiology

Authors : Namit Gaur, Daniel A. Beard, Xiao-Yan Qi, David Benoist, Olivier Bernus, Ruben Coronel, Stanley Nattel, Edward J. Vigmond
Read more
January 2021 MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

3D MRI of explanted sheep hearts with submillimeter isotropic spatial resolution: comparison between diffusion tensor and structure tensor imaging

Authors :
Read more
January 2021 JOURNAL OF THE AMERICAN HEART ASSOCIATION

Electrocardiographic Imaging of Repolarization Abnormalities

Authors :
Read more
January 2021 JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE

Endogenous assessment of myocardial injury with single-shot model-based non-rigid motion-corrected T1 rho mapping

Authors :
Read more
January 2021 HEART RHYTHM

Sex differences in the origin of Purkinje ectopy-initiated idiopathic ventricular fibrillation

Authors :
Read more
January 2021 SCIENTIFIC REPORTS

A 3D high resolution MRI method for the visualization of cardiac fibro-fatty infiltrations

Authors :
Read more
January 2021 MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

3D magnetization transfer (MT) for the visualization of cardiac free-running Purkinje fibers: an ex vivo proof of concept

Authors :
Read more
January 2021 SCIENCE TRANSLATIONAL MEDICINE

Noninvasive detection of spatiotemporal activation-repolarization interactions that prime idiopathic ventricular fibrillation

Authors :
Read more
January 2021 bioRxiv

Optimizing large organ scale micro computed tomography imaging in pig and human hearts using a novel air-drying technique

Authors : Pallares-Lupon, N., Ramlugun, G., Ozenne, V., Duchâteau, J., Delgove, A., Bayer, J., Moreno, A., Constantin, M., Gerneke, D., Sands, G.B., Trew, M.L., Hocini, M., Haissaguerre, M., Vigmond, E.J., Quesson, B., Bernus, O., Walton, R.D.
Read more
January 2021 JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Ultralow temperature cryoablation: Safety and efficacy of preclinical atrial and ventricular lesions

Authors :
Read more
January 2021 CIRCULATION

Electrophysiological Remodelling of Right Atria in Atrial Fibrillation Sheep Model and Role of Succinate in Electrophysiological Properties

Authors :
Read more
January 2021 Cardiac Bioelectric Therapy Mechanisms and Practical Implications

Advanced three-dimensional optical mapping

Authors : Bernus, O., Walton, R.D.
Read more
January 2020

Early Signs of Critical Slowing Down in Heart Surface Electrograms of Ventricular Fibrillation Victims

Authors : Berend Nannes, Rick Quax, Hiroshi Ashikaga, Mélèze Hocini, Remi Dubois, Olivier Bernus, Michel Haïssaguerre
Read more
January 2020 Cardiac Electrophysiology: Clinical Case Review

Early repolarization syndrome during local heart or full body hypothermia

Authors : Haïssaguerre, M., Lavergne, T., Welte, N., Hocini, M., Bernus, O., Marijon, E.
Read more
January 2020 FRONTIERS IN PHYSIOLOGY

Insights Into the Spatiotemporal Patterns of Complexity of Ventricular Fibrillation by Multilead Analysis of Body Surface Potential Maps

Authors :
Read more
January 2020 INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING

Assessment of the healing process after percutaneous implantation of a cardiovascular device: a systematic review

Authors :
Read more
January 2020 SCIENTIFIC REPORTS

Selective inhibition of electrical conduction within the pulmonary veins by α1-adrenergic receptors activation in the Rat

Authors :
Read more
January 2020 bioRxiv

Mechanical stimulation of endocardial Purkinje fibres can trigger ventricular arrhythmias

Authors : White, E., Walton, R., Kaur, S., Power, A., Haïssaguerre, M., Bernus, O., Ward, M.-L.
Read more
January 2020 JOURNAL OF INTERVENTIONAL CARDIOLOGY

Comparison of Two Percutaneous Atrial Septal Defect Occluders for Device Healing and Nickel Release in a Chronic Porcine Model

Authors :
Read more
January 2020 2020 COMPUTING IN CARDIOLOGY

Maximizing the Capture of the Excitable Gap During Ventricular Arrhythmias for Low-Energy Defibrillation

Authors :
Read more
January 2020 FRONTIERS IN PHYSIOLOGY

Body Surface Mapping of Ventricular Repolarization Heterogeneity: AnEx-vivoMultiparameter Study

Authors :
Read more
January 2020 CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY

Long-Lasting Ventricular Fibrillation in Humans ECG Characteristics and Effect of Radiofrequency Ablation

Authors :
Read more
January 2020 2020 COMPUTING IN CARDIOLOGY

Relation of Surface T-wave to Vulnerability to Ventricular Fibrillation in Explanted Structurally Normal Hearts

Authors :
Read more
January 2020 SCIENTIFIC REPORTS

A total closed chest sheep model of cardiogenic shock by percutaneous intracoronary ethanol injection

Authors :
Read more
January 2020 JACC-CLINICAL ELECTROPHYSIOLOGY

Idiopathic Ventricular Fibrillation Role of Purkinje System and Microstructural Myocardial Abnormalities

Authors :
Read more
January 2019 CANADIAN JOURNAL OF CARDIOLOGY

Animal Models of Repaired Tetralogy of Fallot: Current Applications and Future Perspectives

Authors :
Read more
January 2019 FRONTIERS IN PHYSIOLOGY

Optical Imaging of Ventricular Action Potentials in a Torso Tank: A New Platform for Non-Invasive Electrocardiographic Imaging Validation

Authors :
Read more
January 2019 HEART RHYTHM

Depolarization versus repolarization abnormality underlying inferolateral J-wave syndromes: New concepts in sudden cardiac death with apparently normal hearts

Authors :
Read more
January 2019 HEART RHYTHM

Idiopathic ventricular fibrillation with repetitive activity inducible within the distal Purkinje system

Authors :
Read more
January 2019 SCIENTIFIC REPORTS

Wide-area low-energy surface stimulation of large mammalian ventricular tissue

Authors :
Read more
January 2019 JOURNAL OF ELECTROCARDIOLOGY

Advantages and pitfalls of noninvasive electrocardiographic imaging

Authors :
Read more
January 2019 FUNCTIONAL IMAGING AND MODELING OF THE HEART, FIMH 2019

3D High Resolution Imaging of Human Heart for Visualization of the Cardiac Structure

Authors :
Read more
January 2019 JOURNAL OF SENSORS

Orthogonal Multitone Electrical Impedance Spectroscopy (OMEIS) for the Study of Fibrosis Induced by Active Cardiac Implants

Authors :
Read more
January 2019 HEART RHYTHM

Performance and limitations of noninvasive cardiac activation mapping

Authors :
Read more
January 2019 Cardiac Electrophysiology Clinics

The Spectrum of Idiopathic Ventricular Fibrillation and J-Wave Syndromes: Novel Mapping Insights

Authors : Haïssaguerre, M., Nademanee, W., Hocini, M., Duchateau, J., André, C., Lavergne, T., Takigawa, M., Sacher, F., Derval, N., Pambrun, T., Jais, P., Walton, R., Potse, M., Vigmond, E., Dubois, R., Bernus, O.
Read more
January 2019 ACTA PHYSIOLOGICA

Development of optical mapping approaches on left atria from sheep to investigate voltage and calcium characteristics during acute atrial fibrillation

Authors :
Read more
January 2018 2018 COMPUTING IN CARDIOLOGY CONFERENCE (CINC)

Validation of Activation Recovery Interval in Structurally Normal Human Ventricles by Optical Mapping

Authors :
Read more
January 2018 HEART RHYTHM

Cardiac electrical dyssynchrony is accurately detected by noninvasive electrocardiographic imaging

Authors :
Read more
January 2018 FRONTIERS IN PHYSIOLOGY

Dynamic Action Potential Restitution Contributes to Mechanical Restitution in Right Ventricular Myocytes From Pulmonary Hypertensive Rats

Authors :
Read more
January 2018 2018 COMPUTING IN CARDIOLOGY CONFERENCE (CINC)

Determining Surface Stimulation Parameters With Computational Cardiac Electrophysiology to Defibrillate Human Ventricles

Authors :
Read more
January 2018 JACC-CLINICAL ELECTROPHYSIOLOGY

Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced Cardiac Magnetic Resonance and Re-Entrant Activity Assessed With Electrocardiographic Imaging in Human Persistent Atrial Fibrillation

Authors :
Read more
January 2018 FRONTIERS IN PHYSIOLOGY

Unanesthetized Rodents Demonstrate Insensitivity of QT Interval and Ventricular Refractory Period to Pacing Cycle Length

Authors :
Read more
January 2018 FRONTIERS IN PHYSIOLOGY

Role of the Purkinje-Muscle Junction on the Ventricular Repolarization Heterogeneity in the Healthy and Ischemic Ovine Ventricular Myocardium

Authors :
Read more
January 2018 CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY

Arrhythmogenic Remodeling of the Left Ventricle in a Porcine Model of Repaired Tetralogy of Fallot

Authors :
Read more
January 2018 CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY

Compartmentalized Structure of the Moderator Band Provides a Unique Substrate for Macroreentrant Ventricular Tachycardia

Authors :
Read more
January 2018 JOURNAL OF THORACIC DISEASE

Role of animal models for percutaneous atrial septal defect closure

Authors :
Read more
January 2018 CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY

Localized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death

Authors :
Read more
January 2018 EUROPEAN HEART JOURNAL

Electrically stimulating wide-areas of the epicardial surfaces of large mammalian ventricles is achievable with line electrodes

Authors :
Read more
January 2017 EUROPACE

A new cryoenergy for ventricular tachycardia ablation: a proof-of-concept study

Authors :
Read more
January 2017 INTERNATIONAL JOURNAL OF CARDIOLOGY

Platelet function and microparticle levels in atrial fibrillation: Changes during the acute episode

Authors :
Read more
January 2017 HEART

Proarrhythmic remodelling of the right ventricle in a porcine model of repaired tetralogy of Fallot

Authors :
Read more
January 2017 WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY

Unexpected Internalization of a Pulmonary Artery Band in a Porcine Model of Tetralogy of Fallot

Authors :
Read more
January 2017 BIOPHYSICAL JOURNAL

Increased Density of SERCA Pumps at the Periphery of Cardiac Purkinje Cells after Myocardial Infarction

Authors :
Read more
January 2017 BIOPHYSICAL JOURNAL

Properties of New Voltage Sensitive Dyes in Cardiac Field

Authors :
Read more
January 2016 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Magnetic resonance-compatible model of isolated working heart from large animal for multimodal assessment of cardiac function, electrophysiology, and metabolism

Authors :
Read more
January 2016 Computing in Cardiology

Detection of incomplete left bundle branch block by non-invasive electrocardiographic imaging

Authors : Bear, L., Huntjens, P., Coronel, R., Bernus, O., Dallet, C., Walton, R., Dubois, R.
Read more
January 2016 SCIENTIFIC REPORTS

Non-invasive cardiac pacing with image-guided focused ultrasound

Authors :
Read more
January 2016 JOURNAL OF PHYSIOLOGY-LONDON

Intermittent drivers anchoring to structural heterogeneities as a major pathophysiological mechanism of human persistent atrial fibrillation

Authors :
Read more
January 2016 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A technical review of optical mapping of intracellular calcium within myocardial tissue

Authors :
Read more
January 2016 NATURE REVIEWS CARDIOLOGY

Ventricular arrhythmias and the His-Purkinje system

Authors :
Read more
January 2016 JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet function and microparticles levels for patients with paroxysmal and persistent atrial fibrillation including during acute episodes

Authors :
Read more
January 2016 2016 COMPUTING IN CARDIOLOGY CONFERENCE (CINC), VOL 43

Detection of Incomplete Left Bundle Branch Block by Non-invasive Electrocardiographic Imaging

Authors :
Read more
January 2015 Membrane Potential Imaging in the Nervous System and Heart

Membrane potential imaging in the nervous system and heart

Authors : Canepari, M., Zecevic, D., Bernus, O.
Read more
January 2015 Advances in experimental medicine and biology

Preface

Authors : Canepari, M., Bernus, O., Zecevic, D.
Read more
January 2015 FUNCTIONAL IMAGING AND MODELING OF THE HEART (FIMH 2015)

Issues in Modeling Cardiac Optical Mapping Measurements

Authors :
Read more
January 2015 Circulation-Arrhythmia and Electrophysiology

Quantification of the Transmural Dynamics of Atrial Fibrillation by Simultaneous Endocardial and Epicardial Optical Mapping in an Acute Sheep Model

Authors :
Read more
January 2015 MEMBRANE POTENTIAL IMAGING IN THE NERVOUS SYSTEM AND HEART

Towards Depth-Resolved Optical Imaging of Cardiac Electrical Activity

Authors :
Read more
January 2015 MEMBRANE POTENTIAL IMAGING IN THE NERVOUS SYSTEM AND HEART

Optical Imaging of Cardiac Action Potential

Authors :
Read more
January 2015 PHYSICAL REVIEW E

Asymptotic wave propagation in excitable media

Authors :
Read more
January 2015 Cardiac Electrophysiology Clinics

Introduction to noninvasive cardiac mapping

Authors : Bear, L., Cuculich, P.S., Bernus, O., Efimov, I., Dubois, R.
Read more
January 2015 PHYSICAL REVIEW LETTERS

Generalized Minimal Principle for Rotor Filaments

Authors :
Read more
January 2015 COMPUTERS IN BIOLOGY AND MEDICINE

Feasibility of a semi-automated method for cardiac conduction velocity analysis of high-resolution activation maps

Authors :
Read more
January 2015 PLOS ONE

Identification of Region-Specific Myocardial Gene Expression Patterns in a Chronic Swine Model of Repaired Tetralogy of Fallot

Authors :
Read more
January 2015 CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY

Irrigated Needle Ablation Creates Larger and More Transmural Ventricular Lesions Compared With Standard Unipolar Ablation in an Ovine Model

Authors :
Read more
January 2015 JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE

Comparison of diffusion tensor imaging by cardiovascular magnetic resonance and gadolinium enhanced 3D image intensity approaches to investigation of structural anisotropy in explanted rat hearts

Authors :
Read more
January 2015 MEMBRANE POTENTIAL IMAGING IN THE NERVOUS SYSTEM AND HEART

Membrane Potential Imaging in the Nervous System and Heart Preface

Authors :
Read more
January 2014 Computing in Cardiology

Localization of three-dimensional sources in cardiac tissue using optical mapping

Authors : Ravon, G., Coudière, Y., Iollo, A., Bernus, O., Walton, R.D.
Read more
January 2014 CIRCULATION

Driver Domains in Persistent Atrial Fibrillation

Authors :
Read more
January 2014 PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline

Authors :
Read more
January 2014 IFMBE Proceedings

Effect of purkinje-myocyte junctions on transmural action potential duration profiles

Authors : Walton, R., Bernus, O., Vigmond, E.J.
Read more
January 2014 CARDIOVASCULAR RESEARCH

Influence of the Purkinje-muscle junction on transmural repolarization heterogeneity

Authors :
Read more
January 2014 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

A framework for quantification of regional cardiac fibrosis from serial sections using 3D whole slide imaging

Authors : Gilbert, S.H., Bernus, O., White, E., Roberts, N., Treanor, D., Magee, D.
Read more
January 2014 EUROPEAN HEART JOURNAL

The role of electrophysiological disturbance in the development of stress-induced cardiomyopathy

Authors :
Read more
January 2014 FUNDAMENTAL & CLINICAL PHARMACOLOGY

Pharmacological isolation of the pulmonary veins in the rat

Authors :
Read more
January 2014 2014 COMPUTING IN CARDIOLOGY CONFERENCE (CINC), VOL 41

Localization of Three-Dimensional Sources in Cardiac Tissue Using Optical Mapping

Authors :
Read more
January 2014 2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)

A Framework for Quantification of Regional Cardiac Fibrosis from Serial Sections using 3D Whole Slide Imaging

Authors :
Read more
January 2013 Computing in Cardiology

A machine learning regularization of the inverse problem in electrocardiography imaging

Authors : Zemzemi, N., Dubois, R., Coudiere, Y., Bernus, O., Haissaguerre, M.
Read more
January 2013 FRONTIERS IN PHYSIOLOGY

Electrophysiological and structural determinants of electrotonic modulation of repolarization by the activation sequence

Authors :
Read more
January 2013 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Electrophysiological changes in heart failure and their implications for arrhythmogenesis

Authors :
Read more
January 2013 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

DT-MRI measurement of myolaminar structure: Accuracy and sensitivity to time post-fixation, b-value and number of directions

Authors : Gilbert, S.H., Smaill, B.H., Walton, R.D., Trew, M.L., Bernus, O.
Read more
January 2013 Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics

Measurement of myocardial structure: 3D structure tensor analysis of high resolution MRI quantitatively compared to DT-MRI

Authors : Gilbert, S., Trew, M., Smaill, B., Radjenovic, A., Bernus, O.
Read more
January 2013 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

A novel approach for deriving global activation maps from non-averaged cardiac optical signals

Authors : Walton, R.D., Bernus, O., Dubois, R.
Read more
January 2013 CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY

Subepicardial Action Potential Characteristics Are a Function of Depth and Activation Sequence in Isolated Rabbit Hearts

Authors :
Read more
January 2013 BIOPHYSICAL JOURNAL

Mechanisms of Steeper APD Restitution in Rat Failing Right Ventricular Myocytes

Authors :
Read more
January 2013 2013 COMPUTING IN CARDIOLOGY CONFERENCE (CINC)

A Machine Learning Regularization of the Inverse Problem in Electrocardiography Imaging

Authors :
Read more
January 2013 2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)

A Novel Approach for Deriving Global Activation Maps from Non-Averaged Cardiac Optical Signals

Authors :
Read more
January 2013 2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)

DT-MRI measurement of myolaminar structure: accuracy and sensitivity to time post-fixation, b-value and number of directions

Authors :
Read more
January 2012 BIOPHYSICAL JOURNAL

Extracting Surface Activation Time from the Optically Recorded Action Potential in Three-Dimensional Myocardium

Authors :
Read more
January 2012 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Visualization and quantification of whole rat heart laminar structure using high-spatial resolution contrast-enhanced MRI

Authors :
Read more
January 2012 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Carbon Monoxide Induces Cardiac Arrhythmia via Induction of the Late Na+ Current

Authors :
Read more
January 2012 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

A framework for myoarchitecture analysis of high resolution cardiac MRI and comparison with diffusion tensor MRI

Authors : Gilbert, S.H., Sands, G.B., Legrice, I.J., Smaill, B.H., Bernus, O., Trew, M.L.
Read more
January 2012 2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)

A Framework for Myoarchitecture Analysis of High Resolution Cardiac MRI and Comparison with Diffusion Tensor MRI

Authors :
Read more
January 2012 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension

Authors :
Read more
January 2012 CARDIOVASCULAR RESEARCH

Anisotropic extracellular resistances influence action potential upstroke within subepicardial layers in the intact isolated rabbit heart

Authors :
Read more
January 2012 BIOPHYSICAL JOURNAL

Altered Action Potential Heterogeneity in Hypertrophic Right Ventricles of Rats

Authors :
Read more
January 2011 Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

Slowed propagation across the compacta-trabeculata interface: a consequence of fiber and sheet anisotropy.

Authors : Gilbert, S.H., Benson, A.P., Walton, R.D., Bernus, O.
Read more
January 2011 Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

Experimental validation of alternating transillumination for imaging intramural wave propagation.

Authors : Walton, R.D., Xavier, C.D., Tachtsidis, I., Bernus, O.
Read more
January 2011 PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Verification of cardiac tissue electrophysiology simulators using an N-version benchmark

Authors :
Read more
January 2011 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy

Authors :
Read more
January 2011 INTERFACE FOCUS

Construction and validation of anisotropic and orthotropic ventricular geometries for quantitative predictive cardiac electrophysiology

Authors :
Read more
January 2011 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Experimental validation of alternating transillumination for imaging intramural wave propagation

Authors : Walton, R.D., Xavier, C.D.L., Tachtsidis, I., Bernus, O.
Read more
January 2011 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Slowed propagation across the compacta-trabeculata interface: A consequence of fiber and sheet anisotropy

Authors : Gilbert, S.H., Benson, A.P., Walton, R.D., Bernus, O.
Read more
January 2011 PHYSICAL REVIEW LETTERS

Accurate Eikonal-Curvature Relation for Wave Fronts in Locally Anisotropic Reaction-Diffusion Systems

Authors :
Read more
January 2011 PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Models of cardiac tissue electrophysiology: Progress, challenges and open questions

Authors :
Read more
January 2011 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)

Slowed Propagation Across the Compacta-Trabeculata Interface: A Consequence of Fiber and Sheet Anisotropy

Authors :
Read more
January 2011 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)

Experimental Validation of Alternating Transillumination for Imaging Intramural Wave Propagation

Authors :
Read more
January 2011 HEART

QUANTIFICATION OF SPATIAL DYNAMICS OF CARDIAC ARRHYTHMIAS

Authors :
Read more
January 2010 HEART RHYTHM

Dual excitation wavelength epifluorescence imaging of transmural electrophysiological properties in intact hearts

Authors :
Read more
January 2010 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium

Authors :
Read more
January 2010 BIOPHYSICAL JOURNAL

Action Potential Duration Modulation by Activation Sequence in Rat Vs. Pig Myocardium

Authors :
Read more
January 2010 BIOPHYSICAL JOURNAL

Evidence of a Pro-Arrhythmic Substrate in the Failing Right Ventricle of Pulmonary Hypertensive Rats

Authors :
Read more
January 2009 PHYSICA D-NONLINEAR PHENOMENA

A geometric theory for scroll wave filaments in anisotropic excitable media

Authors :
Read more
January 2009 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20

Computational Modeling of Cardiac Dual Calcium-Voltage Optical Mapping

Authors :
Read more
January 2009 Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics

Intravoxel fibre structure of the left ventricular free wall and posterior left-right ventricular insertion site in canine myocardium using q-ball imaging

Authors : Dierckx, H., Benson, A.P., Gilbert, S.H., Ries, M.E., Holden, A.V., Verschelde, H., Bernus, O.
Read more
January 2009 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20

A novel near-infrared voltage-sensitive dye reveals the action potential wavefront orientation at increased depths of cardiac tissue

Authors :
Read more
January 2009 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20

Electrotonic effects on action potential duration in perfused rat hearts

Authors :
Read more
January 2009 Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics

A quantitative comparison of the myocardial fibre orientation in the rabbit as determined by histology and by diffusion tensor-mri

Authors : Gilbert, S.H., Bernus, O., Holden, A.V., Benson, A.P.
Read more
January 2009 FUNCTIONAL IMAGING AND MODELING OF THE HEART, PROCEEDINGS

Intravoxel Fibre Structure of the Left Ventricular Free Wall and Posterior Left-Right Ventricular Insertion Site in Canine Myocardium Using Q-Ball Imaging

Authors :
Read more
January 2009 FUNCTIONAL IMAGING AND MODELING OF THE HEART, PROCEEDINGS

A Quantitative Comparison of the Myocardial Fibre Orientation in the Rabbit as Determined by Histology and by Diffusion Tensor-MRI

Authors :
Read more
January 2009 PHYSICA D-NONLINEAR PHENOMENA

Nonlinear waves in excitable media: Approaches to cardiac arrhythmias Preface

Authors :
Read more
January 2008 COMPUTERS IN CARDIOLOGY 2008, VOLS 1 AND 2

Quantifying the Effects of Ischaemia on Electrophysiology and the ST Segment of the ECG in Human Virtual Ventricular Cells and Tissues

Authors :
Read more
January 2008 Biomedical Optics, BIOMED 2008

Inferring intra-myocardial electrical wave orientation from epi-fluorescence recordings in cardiac tissue: Sensitivity to the photon transport model

Authors : Bernus, O., Zemlin, C.W., Matiukas, A., Pertsov, A.M., Hyatt, C.J.
Read more
January 2008 BIOPHYSICAL JOURNAL

Extracting intramural wavefront orientation from optical upstroke shapes in whole hearts

Authors :
Read more
January 2008 OPTICS EXPRESS

Reconstructing subsurface electrical wave orientation from cardiac epi-fluorescence recordings: Monte Carlo versus diffusion approximation

Authors :
Read more
January 2007 OPTICS EXPRESS

Depth-resolved optical imaging of transmural electrical propagation in perfused heart

Authors :
Read more
January 2007 PHYSICAL REVIEW LETTERS

Covariant stringlike dynamics of scroll wave filaments in anisotropic cardiac tissue

Authors :
Read more
January 2007 JOURNAL OF BIOMEDICAL OPTICS

Detection of intramyocardial scroll waves using absorptive transillumination imaging

Authors :
Read more
January 2006 JOURNAL OF BIOMEDICAL OPTICS

Method for the three-dimensional localization of intramyocardial excitation centers using optical imaging

Authors :
Read more
January 2006 Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

Intra-myocardial cusp waves and their manifestation in optical mapping signals

Authors : Bernus, O., Zemlin, C.W., Matiukas, A., Hyatt, C.J., Pertsov, A.M.
Read more
January 2006 PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Comparison of electrophysiological models for human ventricular cells and tissues

Authors :
Read more
January 2006 BIOPHYSICAL JOURNAL

What can we learn from the optically recorded epicardial action potential?

Authors :
Read more
January 2006 PHYSICS IN MEDICINE AND BIOLOGY

Multiplicative optical tomography of cardiac electrical activity

Authors :
Read more
January 2006 2006 28TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-15

Intra-myocardial cusp waves and their manifestation in optical mapping signals

Authors :
Read more
January 2005 PHYSICS IN MEDICINE AND BIOLOGY

Simulation of voltage-sensitive optical signals in three-dimensional slabs of cardiac tissue: application to transillumination and coaxial imaging methods

Authors :
Read more
January 2005 OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE VI

Three-dimensional reconstruction of electrical activity in the heart using optical parallax

Authors :
Read more
January 2005 COMPLEX DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS II

The forward problem in optical mapping of electrical activity in the heart: Application to various imaging methods

Authors :
Read more
January 2005 EUROPACE

Alternating conduction in the ischaemic border zone as precursor of reentrant arrhythmias: A simulation study

Authors :
Read more
January 2004 PHYSICAL REVIEW E

Intramural wave propagation in cardiac tissue: Asymptotic solutions and cusp waves – art. no. 061913

Authors :
Read more
January 2004 CIRCULATION

Conduction alternans in the ischemic border zone as a precursor of reentrant arrhythmias

Authors :
Read more
January 2003 Annual International Conference of the IEEE Engineering in Medicine and Biology Proceedings

The Role of Ca2+ -channel Blockers in the Transition from Ventricular Fibrillation to Ventricular Tachycardia in an Anatomical Model of the Human Ventricles: A Simulation Study

Authors : Bernus, O., Verschelde, H., Panfilov, A.V.
Read more
January 2003 INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS

Reentry in an anatomical model of the human ventricles

Authors :
Read more
January 2003 PHYSICAL REVIEW E

Spiral wave stability in cardiac tissue with biphasic restitution – art. no. 021917

Authors :
Read more
January 2003 PROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4

The role of Ca2+-channel blockers in the transition from ventricular fibrillation to ventricular tachycardia in an anatomical model of the human ventricles:: a simulation study

Authors :
Read more
January 2002 PHYSICS IN MEDICINE AND BIOLOGY

Modified ionic models of cardiac tissue for efficient large scale computations

Authors :
Read more
January 2002 PHYSICS IN MEDICINE AND BIOLOGY

Transition from ventricular fibrillation to ventricular tachycardia: a simulation study on the role of Ca2+-channel blockers in human ventricular tissue

Authors :
Read more
January 2002 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A computationally efficient electrophysiological model of human ventricular cells

Authors :
Read more

Team

Team 3

Cardiac electrophysiology

Specializing in the study and treatment of fibrillatory arrhythmias and dyssynchrony, this team has advanced expertise in rhythmology, experimental electrophysiology, signal processing, and clinical imaging.

Leadership : Olivier BERNUS