Olivier VILLEMAIN

Cardiologist

Professional background

Olivier Villemain did his medical training and undertook specialist training in paediatric cardiology in Paris, France. He graduated from medical school at Paris Descartes University in 2014.
Afterwards, he became Assistant Professor in Paediatric Cardiology at Necker Enfants Malades Hospital in Paris for two years. In addition to his medical training, he studied cardiovascular physiology (M.Sc., Paris Descartes University, 2014) and acoustic physics. Between 2014 and 2017, he worked at the Langevin Institute in Paris, a laboratory specialized in acoustic physics. This resulted in a PhD thesis on the new applications of ultrasound in cardiology in 2017. He worked full-time again in this laboratory, between November 2018 and July 2019, as a collaborator.
In July 2019, he was appointed as a clinician investigator and staff cardiologist at The Hospital for Sick Children (SickKids). He founded and led the Villemain Lab, the first laboratory in the world dedicated to the development and application of ultrafast ultrasound imaging in pediatrics. In just four years, his team published over 30 international publications on this topic.
In August 2023, Olivier Villemain returned to France to work at the Bordeaux University Hospital and the IHU Liryc, where he leads the Ultrafast Imaging team. In July 2025, he was awarded an ERC Starting Grant (5D-ULTRAFAST-HCM).

Funding

Research funding obtained (between 2018 and 2025): a total of €3,350,000, including an ERC Starting Grant (€1,500,000; 2025–2030) and a CIHR Operating Grant of $485,000 CAD (2022–2027, #202203PJT-183888). A total of 20 grants and 5 awards obtained as Principal Investigator.

Patents

Methods and Apparatus for Treating Valvular Disease. Granted. Patent #: 15/557455. United States. Messas E, Pernot M, Tanter M, and Villemain O;
Systems and Methods for Assessing Myocardial Work. Provisional. Patent #: P4920US00. Villemain O, Baranger J, Venet M, and Mertens L.

Publications 112

January 2026 EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING

Measuring myocardial stiffness: when natural waves play tricks on us

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January 2026 JACC-CARDIOVASCULAR IMAGING

All the Way Up Natural Wave Imaging Is (Almost) Ready For Clinical Practice

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January 2026 EUROPEAN HEART JOURNAL

European Research Council starting grant: ultrafast ultrasound imaging for genotype-phenotype interplay in hypertrophic cardiomyopathy

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January 2026 JOURNAL OF THORACIC DISEASE

Push the flow-mind the micro: renal microcirculation during high-flow cardiopulmonary bypass

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January 2026 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Noninvasive Methods to Assess Vascular Health in Children and Adolescents: Current State-of-the-Art and Future Perspectives

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November 2025

Revisiting the concept of “phenotype” in pediatric hypertrophic cardiomyopathy using myocardial stiffness and strain variations assessed by ultrafast ultrasound imaging

Authors : Aimen Malik, Maelys Venet, Seema Mital, Clement Papadacci, Mathieu Pernot, Mark Friedberg, Luc Mertens, Jerome Baranger, Olivier Villemain
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May 2025 Journal of the American Heart Association

Are We Getting Better?: Ongoing Challenges of Atrioventricular Valve Repair in Children With Single Ventricle Physiology

Authors : Sachiko Kadowaki, Maelys Venet, Teerapong Tocharoenchok, Kok Hooi Yap, Chun‐Po Steve Fan, Yasmin Zahiri, Mimi X. Deng, Olivier Villemain, Alejandro Floh, David J. Barron, Osami Honjo
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January 2025 EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING

Towards non-invasive assessment of myocardial work using myocardial stiffness and strain: a human pilot study

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January 2025 PRENATAL DIAGNOSIS

High Intensity Focused Ultrasound-Induced Ablation of the Intra-Abdominal Umbilical Vessels in a Rabbit Fetus: A Model Treatment of Twin-Reversed Arterial Perfusion Sequence

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January 2025 EXPERT REVIEW OF MEDICAL DEVICES

Ultrafast 3D echocardiography: get fast or die tryin’

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January 2025 NATURE COMMUNICATIONS

Oxidative stress-induced intervertebral disc remodelling and elevated stiffness drive idiopathic scoliosis in preclinical models

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January 2025 SCIENTIFIC REPORTS

Towards quantitative assessment of cerebrovascular autoregulation in human neonates using ultrafast ultrasound imaging

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January 2025 JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Long-term enlargement of the neo-aortic root and aortic arch following arch reconstruction in hypoplastic left heart syndrome

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January 2025 JACC-CARDIOVASCULAR IMAGING

Impact of Right Ventricular Pressure Overload on Myocardial Stiffness Assessed by Natural Wave Imaging

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January 2025 FUNCTIONAL IMAGING AND MODELING OF THE HEART, FIMH 2025, PT II

Myocardial Stiffness Quantification Using Ultrasound Shear Wave Elastography and Reduced Modeling for Subject-Specific Simulations

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January 2024 JOURNAL OF CLINICAL MEDICINE

Outcomes Following Closure of Secundum Atrial Septal Defect in Children ≤ 15 kg in a French Tertiary Centre

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January 2024 PHYSICS IN MEDICINE AND BIOLOGY

Automated classification of cerebral arteries and veins in the neonate using ultrafast doppler spectrogram

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January 2024 CIRCULATION

Toward Quantitative Assessment of Cerebrovascular Autoregulation in Neonates using Ultrafast Ultrasound Power Doppler

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January 2024 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Diastolic Myocardial Stiffness Assessed by Shear Wave Elastography in Children With a Fontan Circulation

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January 2024 FRONTIERS IN PHYSICS

Detection of natural pulse waves (PWs) in 3D using high frame rate imaging for anisotropy characterization

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January 2024 SCIENTIFIC REPORTS

The brain of fetuses with congenital diaphragmatic hernia shows signs of hypoxic injury with loss of progenitor cells, neurons, and oligodendrocytes

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January 2024 CARDIOVASCULAR DIABETOLOGY

Abnormal vascular thickness and stiffness in young adults with type 1 diabetes: new insights from cutting-edge ultrasound modalities

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January 2024 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Modeling the Relationship Between Diastolic Phenotype and Outcomes in Pediatric Hypertrophic Cardiomyopathy

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January 2024 HELLENIC JOURNAL OF CARDIOLOGY

Adverse remodelling in tetralogy of Fallot: From risk factors to imaging analysis and future perspectives

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January 2024 JACC-CARDIOVASCULAR IMAGING

Comparison Between Acoustic Radiation Force-Induced and Natural Wave Velocities for Myocardial Stiffness Assessment in Hypertrophic Cardiomyopathy

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January 2023 BIOMATERIALS

Assessing engineered tissues and biomaterials using ultrasound imaging: In vitro and in vivo applications

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January 2023 ANNALS OF THORACIC SURGERY

Melody Mitral Valve Is a Promising Alternative to Mechanical Valve Replacement for Young Children

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January 2023 CONGENITAL HEART DISEASE

Compound Heterozygous PLD1 Variants in Right-Sided Heart Malformations

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January 2023 SCIENCE ADVANCES

The fundamental mechanisms of the Korotkoff sounds generation

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January 2023 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Impact of Ventricular Geometric Characteristics on Myocardial Stiffness Assessment Using Shear-Wave Velocity in Healthy Children and Young Adults

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January 2023 IEEE TRANSACTIONS ON MEDICAL IMAGING

Longitudinal Assessment of Cerebral Blood Volume Variation in Human Neonates Using Ultrafast Power Doppler and Diverging Waves

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January 2023 IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

Fast Thresholding of SVD Clutter Filter Using the Spatial Similarity Matrix and a Sum-Table Algorithm

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January 2023 FRONTIERS IN CARDIOVASCULAR MEDICINE

Local arterial stiffness measured by ultrafast ultrasound imaging in childhood cancer survivors treated with anthracyclines

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January 2023 JACC-ADVANCES

Ultrafast Power Doppler for Detecting Intraoperative Myocardial Perfusion in Infants With Critical Congenital Heart Disease

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January 2023 PHYSIOLOGY

Spinal stiffness assessment by shear wave imaging in a genetic zebrafish scoliosis model treated with anti-inflammatory medication

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January 2023 Arxiv

Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging

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January 2023 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

LONG TERM AORTIC ARCH GROWTH AFTER DAMUS-KAYE-STANSEL (DKS) ARCH RECONSTRUCTION IN PATIENTS WITH HYPOPLASTIC LEFT HEART SYNDROME (HLHS) AND VARIANTS

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January 2023 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

IMPACT OF CARDIOPULMONARY BYPASS ON CEREBROVASCULAR AUTOREGULATION ASSESSED BY ULTRAFAST ULTRASOUND IMAGING

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January 2023 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

TOWARDS TRANSTHORACIC QUANTITATIVE MYOCARDIAL PERFUSION ASSESSMENT USING ULTRAFAST ULTRASOUND IMAGING

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January 2023 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

MYOCARDIAL STIFFNESS ASSESSMENT BY ULTRASOUND IN HUMANS: COMPARISON BETWEEN SHEAR WAVE ELASTOGRAPHY, NATURAL MECHANICAL WAVES, AND MYOCARDIAL STRETCH INDUCED BY ATRIAL KICK

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January 2023 JOURNAL OF PHYSIOLOGY-LONDON

Impact of cardiopulmonary bypass on cerebrovascular autoregulation assessed by ultrafast ultrasound imaging

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January 2022 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Local Arterial Stiffness Assessment: Comparison of Pulse Wave Velocity Assessed by Ultrafast Ultrasound Imaging versus the Bramwell-Hill Equation

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January 2022 FRONTIERS IN RADIOLOGY

Artificial intelligence in the pediatric echocardiography laboratory: Automation, physiology, and outcomes

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January 2022 FRONTIERS IN PEDIATRICS

Editorial: Next research perspectives in pediatric cardiology for imaging and interventions

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January 2022 FRONTIERS IN PEDIATRICS

Nuclear Imaging in Pediatric Cardiology: Principles and Applications

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January 2022 JACC-CARDIOVASCULAR IMAGING

Coronary Flow Assessment Using 3-Dimensional Ultrafast Ultrasound Localization Microscopy

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January 2022 PHYSICS IN MEDICINE AND BIOLOGY

Improving coronary ultrafast Doppler angiography using fractional moving blood volume and motion-adaptive ensemble length

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January 2022 FRONTIERS IN PEDIATRICS

Organization of Pediatric Echocardiography Laboratories: Impact of Sonographers on Clinical, Academic, and Financial Performance

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January 2022 EUROPEAN HEART JOURNAL-CASE REPORTS

Innocent until proven guilty? Longstanding atrial ectopy preceding cardiac rhabdomyoma diagnosis in tuberous sclerosis complex: a case report

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January 2022 NATURE CARDIOVASCULAR RESEARCH

A guide for assessment of myocardial stiffness in health and disease

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January 2022 JACC-CARDIOVASCULAR IMAGING

To Be, or Not to Be Diastolic About Natural Mechanical Waves After Mitral Valve Closure

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January 2022 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Understanding Complex Interactions in Pediatric Diastolic Function Assessment

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January 2022 JOURNAL OF THE AMERICAN HEART ASSOCIATION

Pediatric Hypertrophic Cardiomyopathy: Exploring the Genotype-Phenotype Association

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January 2022 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Smart Ultrasound Device for Non-Invasive Real-Time Myocardial Stiffness Quantification of the Human Heart

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January 2021 CIRCULATION

Noninvasive Assessment of Contractility and Compliance of the Left Ventricle in Children: Myocardial Stiffness Measured Throughout the Cardiac Cycle by Shear Wave Imaging

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January 2021 CIRCULATION

Impact of Cardiopulmonary Bypass Surgery on Myocardial Perfusion Assessed by Ultrafast Power Doppler: A Human Proof-of-Concept Study

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January 2021 CIRCULATION

Systolic and Diastolic Myocardial Stiffness of the Right Ventricle Free Wall Assessed by Ultrafast Ultrasound Imaging in Humans: Comparison with Pressure-Volume Loop in Healthy Volunteers and Pulmonary Arterial Hypertension Patients

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January 2021 CIRCULATION

Supervised Machine Learning for Relating Echocardiographic Parameters to Invasive Pressure Measurements in Pediatric Diastolic Function Assessment

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January 2021 CIRCULATION

Quantitative Assessment of Neonatal Brain Perfusion by Ultrafast Power Doppler in the Operating Room

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January 2021 PAEDIATRICS & CHILD HEALTH

A 12-year-old boy with fever and weight loss

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January 2021 JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Outcomes after common arterial trunk repair: Impact of the surgical technique

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January 2021 NEUROIMAGE-CLINICAL

Brain perfusion imaging in neonates

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January 2021 JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

The Use of 3D Echocardiography in Surgical Planning of the Mitral Valve in Pediatric Cardiology

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January 2021 JTCVS TECHNIQUES

Utility of a bespoke 3-dimensional printed model in complex transposition

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September 2020 Cardiology in the young

Antenatal occlusion of a ductal arteriosus aneurysm: a potential postnatal surgical emergency. Case report and literature review.

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August 2020 IEEE transactions on medical imaging

4D ultrafast ultrasound imaging of naturally occurring shear waves in the human heart.

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August 2020 Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Saving the endangered physician-scientists: reintroducing them to an environment of administrative support.

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June 2020 Physics in medicine and biology

Quantitative imaging of coronary flows using 3D ultrafast Doppler coronary angiography.

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January 2020 Journal of hypertension

Changes in segmental pulse wave velocity of the thoracic aorta with age and left ventricular remodelling. An MRI 4D flow study.

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January 2020 EXPERT REVIEW OF MEDICAL DEVICES

Non-invasive imaging techniques to assess myocardial perfusion (Oct, 10.1080/17434440.2020.1834844, 2020)

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January 2020 CIRCULATION

Mitral Valve Replacement With a Melody™ Valve Improves Survival for Young Children Compared to Mechanical Mitral Valve Replacement – A Case-Matched Control Study

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January 2020 JACC-CARDIOVASCULAR IMAGING

Myocardial Stiffness Assessment by Ultrasound Are We Ready for the Clinical “Lift Off”?

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January 2020 EXPERT REVIEW OF MEDICAL DEVICES

Non-invasive imaging techniques to assess myocardial perfusion

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January 2020 Arxiv

4D ultrafast ultrasound imaging of naturally occurring shear waves in the human heart

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January 2020 JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Blood Flow Imaging with Ultrafast Doppler

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November 2019 JACC. Cardiovascular imaging

Ultrafast Ultrasound Imaging in Pediatric and Adult Cardiology: Techniques, Applications, and Perspectives.

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September 2019 Interactive cardiovascular and thoracic surgery

Risk factors of mortality and recoarctation after coarctation repair in infancy.

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May 2019 Cardiology in the young

Cardiac catheterisation in infants weighing less than 2500 grams.

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April 2019 Physics in medicine and biology

4D simultaneous tissue and blood flow Doppler imaging: revisiting cardiac Doppler index with single heart beat 4D ultrafast echocardiography.

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March 2019 Jacc. Cardiovascular Imaging

In the Heart of Stiffness: Are Natural Heart Vibrations Reliable Enough to Assess Myocardial Stiffness, The New Holy Grail in Echocardiography?

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September 2018 Journal of thoracic disease

Role of animal models for percutaneous atrial septal defect closure.

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July 2018 Cardiology in the young

Radiation exposure in transcatheter patent ductus arteriosus closure: time to tune? -CORRIGENDUM.

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May 2018 The Journal of Thoracic and Cardiovascular Surgery

What matters more in testing bacterial adhesion: Flow conditions or choice of bacterial strain?

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March 2018 JACC. Cardiovascular imaging

Myocardial Stiffness Evaluation Using Noninvasive Shear Wave Imaging in Healthy and Hypertrophic Cardiomyopathic Adults.

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March 2018 Archives of cardiovascular diseases

French national survey on infective endocarditis and the Melody™ valve in percutaneous pulmonary valve implantation.

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January 2018 Cardiology in the young

Radiation exposure in transcatheter patent ductus arteriosus closure: time to tune?

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January 2018 Jacc. Cardiovascular Imaging

Stone Liver, Heart in Danger: Could the Liver Stiffness Assessment Improve the Management of Patients With Heart Failure?

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January 2018 EUROPEAN HEART JOURNAL

Fever within 48h after Melody implantation is a risk factor of late infective endocarditis

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January 2018 EUROPEAN HEART JOURNAL

Early and long-term results of biventricular repair of Tetralogy of Fallot with or without pulmonary atresia

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December 2017 Archives of cardiovascular diseases

Percutaneous coronary artery interventions in the paediatric population: Periprocedural and late outcome.

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November 2017 Jacc. Cardiovascular Imaging

Myocardial Stiffness Assessment Using Shear Wave Imaging in Pediatric Hypertrophic Cardiomyopathy.

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October 2017 Archives of cardiovascular diseases

Reduction of radiation exposure in transcatheter atrial septal defect closure: How low must we go?

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August 2017 JACC. Cardiovascular imaging

Noninvasive Imaging of the Coronary Vasculature Using Ultrafast Ultrasound.

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August 2017 JACC. Basic to translational science

Pulsed Cavitational Ultrasound Softening: a new non-invasive therapeutic approach of calcified bioprosthetic valve stenosis.

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April 2017 Jacc. Cardiovascular Imaging

Toward Noninvasive Assessment of CVP Variations Using Real-Time and Quantitative Liver Stiffness Estimation.

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April 2017 Scientific reports

Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging.

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January 2017 IRBM

Non-invasive Myocardial Shear Wave Elastography Device for Clinical Applications in Cardiology

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January 2017 EUROPEAN JOURNAL OF HEART FAILURE

Quantitative assessment of myocardial stiffness using transthoracic shear wave imaging in healthy and hypertrophic cardiomyopathy adults

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January 2017 EUROPEAN JOURNAL OF HEART FAILURE

Towards non-invasive assessment of central venous pressure variations using real time and quantitative liver stiffness estimation

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August 2016 European heart journal cardiovascular Imaging

Pulsed cavitational ultrasound for non-invasive chordal cutting guided by real-time 3D echocardiography.

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May 2016 The Journal of Thoracic and Cardiovascular Surgery

Impact of anatomic characteristics and initial biventricular surgical strategy on outcomes in various forms of double-outlet right ventricle.

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May 2016 Seminars in thoracic and cardiovascular surgery

Double-Outlet Right Ventricle With Noncommitted Ventricular Septal Defect and 2 Adequate Ventricles: Is Anatomical Repair Advantageous?

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February 2016 Seminars in thoracic and cardiovascular surgery

Double Outlet Right Ventricle with Noncommitted Ventricular Septal Defect and Two Adequate Ventricles: is Anatomical Repair Advantageous?

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February 2016 IEEE transactions on ultrasonics, ferroelectrics, and frequency control

Ultrafast Harmonic Coherent Compound (UHCC) Imaging for High Frame Rate Echocardiography and Shear-Wave Elastography.

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January 2016 EUROPEAN HEART JOURNAL

Myocardial stiffness assessment using shear wave imaging in healthy children and hypertrophic cardiomyopathy

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January 2016 EUROPEAN HEART JOURNAL

Liver stiffness by shear wave elastography, new noninvasive and quantitative tool for acute variation estimation of central venous pressure in real-time?

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January 2016 CIRCULATION

Evaluation of Myocardial Stiffness Change Over Age in Healthy Adult and Hypertrophic Cardiomyopathy Populations Using New Noninvasive Ultrasound Shear Wave Imaging

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July 2015 International journal of cardiology

Selective propensity of bovine jugular vein material to bacterial adhesions: An in-vitro study.

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January 2015 EUROPEAN HEART JOURNAL

Double outlet right ventricle with non-committed ventricular septal defect

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January 2015 EUROPEAN HEART JOURNAL

Non invasive ultrasonic chordal cutting

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January 2015 EUROPEAN HEART JOURNAL

Results and long-term follow-up for double-outlet right ventricle with biventricular repair

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January 2015 EUROPEAN HEART JOURNAL

Selective propensity of bovine jugular vein to bacterial adhesion and impact of percutaneous pulmonary valve implantation procedural steps in genesis of infective endocarditis: an in-vitro study

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