Pascale DOZOLME

CRCN Biotechnology programme manager

Professional background

Virus: Research on receptors of the Beet Western Yellows Virus in the aphid vector Myzus persicae, production of monoclonal antibodies and characterization by Biacore 1998-2004. Co-founder of the company SEDIAG SA in 2001 Still active
Fungi: Study of the molecular mechanism of symbiosis establishment at the Appressoria stage 2004-2010 Study of fumonisins produced by Fusarium verticillioides 2010-2015. Co-founder of the company France Morilles SA in 2011 Still active
Toxicology: Determination of in vitro toxicity of natural compounds (plants, fungi) 2015-2018
G-quadruplexes: Determination of in vitro toxicity of ligands on human cells 2018-present
Asthma, COPD: Determination and identification of secondary metabolites of fungal compounds allowing the reduction of bronchial smooth muscle 2021-present

Members

Pascale DOZOLME

Professional background

Publications 5

Design, Synthesis, and In Vitro Antimalarial Evaluation of New 1,3,5-Tris[(4-(Substituted-Aminomethyl)Phenoxy)Methyl]Benzenes

Synthesis and Antimalarial Evaluation of New 1,3,5-tris[(4-(Substituted-aminomethyl)phenyl)methyl]benzene Derivatives: A Novel Alternative Antiparasitic Scaffold

Synthesis and Antiprotozoal Evaluation of New 2,9-bis[(pyridinylalkylaminomethyl) phenyl]-1,10-Phenanthroline Derivatives by Targeting G-quadruplex, an Interesting Pharmacophore Against Drug Efflux

In vitro and in vivo Evaluation of the Toxicity Roots of Leptadeniahastata (PER) Decne. Cytotoxicity on Caco2 and HepG2 Cells, Acute and Subacute Toxicity on Wistar Rats

Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-Bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux

Team

Bronchial remodeling