Members

Patrick BERGER

University Professor - Hospital Practitioner. Team 2 leader / Manager of the team 2

Email : [email protected]
ORCID : 0000-0003-4702-0343

Professional background

Since 2025 Head of the asthma hospitalization unit, University hospital of Bordeaux (CHU)
Since 2024 Head of the Lung Function Testing department, University hospital of Bordeaux (CHU)
Since 2022 Director of the Cardio-Thoracic Research Center of Bordeaux (CRCTB, INSERM U1045), University of Bordeaux
Since 2011 Director of the Bronchial Remodeling team (CRCTB, INSERM U1045), University of Bordeaux
Since 2008 Professor of Physiology (University of Bordeaux), pulmonologist hospital practitioner (CHU)

Funding

ANR international PRC (2024-2028)
AstraZeneca unrestricted grant (2021-2023)
AST Prematuration grant (2021-2024)
FRM Team (2017-2020)

Patents

1. Berger P, Dupin I, Girodet PO.
Patent filed on January 28, 2015 under serial number EP No. 15152886.6 with the European Patent Office: New compositions and methods of treating and/or preventing Chronic Obstructive Pulmonary Disease.
PCT filed on January 28, 2016 (PCT/EP2016/051771) for the USA, Canada, Australia, BRIC countries, Israel, Japan, and Eurasia.
Patent granted on 10/09/2019 under serial number EP No. 3050574: Use of plerixafor for treating and/or preventing acute exacerbations of chronic obstructive pulmonary disease.
International publication on August 4, 2016 under No. WO/2016/120369A1.
License signed on July 26, 2025 with 4 Living Biotech.

2. Dournes G, Baldacci F, Laurent F, Berger P.
French patent filed on May 27, 2016 under serial number 22605-FR with the French Patent Office: Process for the geometric characterization of lung airways by MRI.
European extension filed on May 29, 2017 with the European Patent Office: MRI Method for the geometrical characterization of pulmonary airways (No. 17726309.2; No. 16/304,574), granted on July 5, 2019.
US extension filed on May 29, 2017 and granted under US No. 11,361,429 B2 on June 14, 2022.
International publication on November 30, 2017 under No. WO/2017/203064A1.

3. Dournes G, Benlala I, Laurent F, Berger P.
French patent filed on July 31, 2019 under serial number 1908734-FR with the French Patent Office: Method for generating a biomarker system.
PCT filed on June 3, 2020 (PCT/EP2020/065380) with the European Patent Office: Method for generating a biomarker system.
Patent granted on February 4, 2021 under No. 3099621.
International publication on February 4, 2021 under No. WO/2021/018439A1.

4. Berger P, Dupin I, Prevel R, James C, Girodet PO, Bismuth K, Rattenbach R.
Patent filed on May 7, 2020 under serial number EP No. 20173595.8 with the European Patent Office (under examination): New compositions and methods of treating COVID-19 Disease.
License agreement signed by 4-Living Biotech on July 16, 2021.
International publication on November 11, 2021 under No. WO/2021/224356.

5. Rattenbach R, Breton J, Chéron V, Prevel R, Berger P.
CXCR4 inhibitor compound in the treatment and/or prevention of severe ARDS.
License signed on July 26, 2025 with 4 Living Biotech.
International publication on October 2, 2025 under No. WO/2025/202445.

Publications 295

December 2025 Radiology: Cardiothoracic Imaging

Quantitative CT Evaluation of Bronchiectasis Improvement in Cystic Fibrosis after CFTR-Modulator Therapy

Authors : Amel Imene Hadj Bouzid, Daphné Pasche, Ilyes Benlala, Stéphanie Bui, Julie Macey, Jean Delmas, Fabien Beaufils, Baudouin Denis de Senneville, Patrick Berger, Gaël Dournes
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April 2025 European Respiratory Journal

2024 imaging criteria for allergic bronchopulmonary aspergillosis: which diagnostic cut-offs? Are chest radiograph and CT comparable?

Authors : Gael Dournes, Ilyes Benlala, Patrick Berger
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March 2025 Insights into Imaging

Bronchial wall T2w MRI signal as a new imaging biomarker of severe asthma

Authors : Ilyes Benlala, Gaël Dournes, Pierre-Olivier Girodet, François Laurent, Wadie Ben Hassen, Fabien Baldacci, Baudouin Denis De Senneville, Patrick Berger
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March 2025 Biomedicine & Pharmacotherapy

Celastrol has beneficial effects on pulmonary hypertension associated with bronchopulmonary dysplasia: Preclinical study outcomes

Authors : Claire-Marie Pilard, Guillaume Cardouat, Isabel Gauthereau, Laure Gassiat, Mathilde Dubois, Paul Robillard, Fanny Sauvestre, Fanny Pelluard, Sophie Berenguer, Melie Sarreau, Stéphane Claverol, Caroline Tokarski, Loïc Sentilhes, Frederic Coatleven, Marie Vincienne, Roger Marthan, Eric Dumas-de-la-roque, Patrick Berger, Mark K. Friedberg, Laurent Renesme, Véronique Freund-Michel, Christelle Guibert
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January 2025 EUROPEAN RADIOLOGY

Artificial intelligence-driven volumetric CT outcome score in cystic fibrosis: longitudinal and multicenter validation with/without modulators treatment

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January 2025 JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Long-term effectiveness and safety of dupilumab in severe asthma: A 5-year real-world multicenter study

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January 2025 RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Validity and reliability of anharmonic morphological ventilometry for the characterisation of human breathing

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January 2025 bioRxiv

Tunable 3D Alveolosphere Model from Human Alveolar Cells: A Breakthrough Tool to Explore Emphysema Pathophysiology

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January 2025 2025 IEEE 22ND INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING, ISBI

3D SEMANTIC SEGMENTATION OF AIRWAY ABNORMALITIES ON UTE-MRI WITH REINFORCEMENT LEARNING ON DEEP SUPERVISION

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December 2024 BMJ Open Respiratory Research

What is the true target population for biologics in real-life COPD or asthma-COPD overlap patients?

Authors : Maéva Zysman, Fanchon Herman, Léo Grassion, Camille Taillé, Jesus Gonzalez-Bermejo, Marina Guecamburu, Nicolas Roche, Arthur Pavot, Pierre-Olivier Girodet, Arnaud Bourdin, Nicolas Molinari, Patrick Berger
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December 2024 European Respiratory Journal

A novelin vitrotubular model to recapitulate features of distal airways: the bronchioid

Authors : Elise Maurat, Katharina Raasch, Alexander M. Leipold, Pauline Henrot, Maeva Zysman, Renaud Prevel, Thomas Trian, Tobias Krammer, Vanessa Bergeron, Matthieu Thumerel, Pierre Nassoy, Patrick Berger, Antoine-Emmanuel Saliba, Laetitia Andrique, Gaëlle Recher, Isabelle Dupin
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December 2024 Revue des Maladies Respiratoires

Imagerie tomodensitométrique de la bronchopneumopathie chronique obstructive : quels aspects et quel rôle ?

Authors : G. Dournes, M. Zysman, I. Benlala, P. Berger
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January 2024 PEDIATRIC ALLERGY AND IMMUNOLOGY

Airway bacterial colonization is associated with bronchial remodeling in severe preschool wheezers

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January 2024 PEDIATRIC ALLERGY AND IMMUNOLOGY

COBRAPed cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease?

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January 2024 JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Clinical and bronchial parameters associated with the exacerbation frequency of severe preschool wheezers

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January 2024 FRONTIERS IN PHARMACOLOGY

Commentary: Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration

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January 2024 ARTHRITIS & RHEUMATOLOGY

Guselkumab and Golimumab Combination Induction Therapy in Ulcerative Colitis Results in Early Local Tissue Healing That Is Sustained Through Guselkumab Maintenance Therapy

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January 2024 AMERICAN JOURNAL OF GASTROENTEROLOGY

Guselkumab Decreases Key Cellular Inflammatory Processes Across Ileum and Colon Tissue in Crohn’s Disease

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January 2024 AMERICAN JOURNAL OF GASTROENTEROLOGY

Histologic and Combined Histologic and Endoscopic Outcomes After Guselkumab Maintenance Therapy in Patients With Moderately to Severely Active Ulcerative Colitis: Week 44 Results From the Phase 3 QUASAR Maintenance Study

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January 2024 GASTROENTEROLOGY

IDENTIFICATION AND RANKING OF GENE MODULE ASSOCIATION WITH HISTOLOGIC FEATURES IN ULCERATIVE COLITIS

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January 2024 GASTROENTEROLOGY

GUSELKUMAB AND GOLIMUMAB COMBINATION INDUCTION THERAPY IN ULCERATIVE COLITIS RESULTS IN EARLY LOCAL TISSUE HEALING THAT IS SUSTAINED THROUGH GUSELKUMAB MAINTENANCE THERAPY

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January 2024 GASTROENTEROLOGY

DEVELOPMENT OF A CROHN’S DISEASE MOLECULAR ACTIVITY SCORE TO IDENTIFY REGION-SPECIFIC CHRONICALLY INFLAMED AND NONINFLAMED PROCESSES

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January 2024 GASTROENTEROLOGY

HIGH PERFORMANCE ESTIMATION OF GEBOES SCORE IN ULCERATIVE COLITIS USING MULTI-INSTANCE LEARNING AND FOUNDATIONAL MODELS

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January 2024 GASTROENTEROLOGY

GUSELKUMAB INDUCTION RESTORES INTESTINAL IMMUNE HOMEOSTASIS AND PROMOTES EPITHELIAL REPAIR IN MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS

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January 2024 bioRxiv

A novel in vitro tubular model to recapitulate features of distal airways: The bronchioid

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January 2024 JOURNAL OF CROHNS & COLITIS

Deep Learning Models Capture Histological Disease Activity in Crohn’s Disease and Ulcerative Colitis with High Fidelity

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July 2023 European Radiology

Development and external validation of a prediction model for the transition from mild to moderate or severe form of COVID-19

Authors : Maéva Zysman, Julien Asselineau, Olivier Saut, Eric Frison, Mathilde Oranger, Arnaud Maurac, Jeremy Charriot, Rkia Achkir, Sophie Regueme, Emilie Klein, Sébastien Bommart, Arnaud Bourdin, Gael Dournes, Julien Casteigt, Alain Blum, Gilbert Ferretti, Bruno Degano, Rodolphe Thiébaut, Francois Chabot, Patrick Berger, Francois Laurent, Ilyes Benlala
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July 2023 Radiology

Generating High-Resolution Synthetic CT from Lung MRI with Ultrashort Echo Times: Initial Evaluation in Cystic Fibrosis

Authors : Arthur Longuefosse, Julien Raoult, Ilyes Benlala, Baudouin Denis de Senneville, Thomas Benkert, Julie Macey, Stéphanie Bui, Patrick Berger, Gilbert Ferretti, Jean-Yves Gaubert, Renan Liberge, Antoine Hutt, Baptiste Morel, François Laurent, Fabien Baldacci, Gaël Dournes
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June 2023 Journal of Magnetic Resonance Imaging

Non‐Contrast‐Enhanced Functional Lung MRI to Evaluate Treatment Response of Allergic Bronchopulmonary Aspergillosis in Patients With Cystic Fibrosis: A Pilot Study

Authors : Ilyes Benlala, Rabea Klaar, Thomas Gaass, Julie Macey, Stéphanie Bui, Baudouin Denis De Senneville, Patrick Berger, François Laurent, Gael Dournes, Julien Dinkel
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April 2023 Microbiology Spectrum

Lung Mycobiota α-Diversity Is Linked to Severity in Critically Ill Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Authors : Raphaël Enaud, Pierre Sioniac, Sebastien Imbert, Pierre-Laurent Janvier, Adrian Camino, Hoang-Nam Bui, Odile Pillet, Arthur Orieux, Alexandre Boyer, Patrick Berger, Didier Gruson, Laurence Delhaes, Renaud Prevel
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April 2023 Annals of Intensive Care

Bridging gut microbiota composition with extended-spectrum beta-lactamase Enterobacteriales faecal carriage in critically ill patients (microbe cohort study)

Authors : Renaud Prevel, Raphaël Enaud, Arthur Orieux, Adrian Camino, Pierre Sioniac, Fatima M’Zali, Véronique Dubois, Patrick Berger, Alexandre Boyer, Laurence Delhaes, Didier Gruson
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February 2023 Frontiers in Pediatrics

Adherence, reliability, and variability of home spirometry telemonitoring in cystic fibrosis

Authors : Fabien Beaufils, Raphaël Enaud, François Gallode, Grégory Boucher, Julie Macey, Patrick Berger, Michael Fayon, Stéphanie Bui
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February 2023 Annals of Allergy, Asthma & Immunology

Long-term efficacy of dupilumab in asthma with or without chronic rhinosinusitis and nasal polyps

Authors : Patrick Berger, Andrew Menzies-Gow, Anju T. Peters, Piotr Kuna, Klaus F. Rabe, Arman Altincatal, Xavier Soler, Nami Pandit-Abid, Shahid Siddiqui, Juby A. Jacob-Nara, Yamo Deniz, Paul J. Rowe
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January 2023 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting

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January 2023 JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models

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January 2023 medRxiv

Non-contrast-Enhanced Functional Lung MRI to evaluate treatment response of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis: a pilot study

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January 2023 bioRxiv

CXCR4 blockade alleviates pulmonary and cardiac outcomes in young COPD

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January 2023 AMERICAN JOURNAL OF GASTROENTEROLOGY

Impact of Guselkumab Therapy on Histologic and Combined Histologic and Endoscopic Outcomes in Patients With Moderately to Severely Active Ulcerative Colitis: Week 12 Results From the Phase 3 QUASAR Induction Study

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January 2023 ARTHRITIS & RHEUMATOLOGY

Differential and Combinatorial Mechanism of Action of Golimumab and Guselkumab in Ulcerative Colitis Induction Therapy: IL-23 Blockade Drives Restoration of Normal Epithelium and Mucosal Healing

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January 2023 EUROPEAN RESPIRATORY JOURNAL

Lung microbiota compositions differ between influenza, COVID-19 and bacteria-related acute respiratory distress syndrome

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January 2023 GUT

Biopsy and blood-based molecular biomarker of inflammation in IBD

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January 2023 ERJ OPEN RESEARCH

Using an electronic diary and wristband accelerometer to detect exacerbations and activity levels in COPD: a feasibility study

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January 2023 GASTROENTEROLOGY

USTEKINUMAB MODULATES IL-12 AND IL-23-RELATED CELL TYPE-SPECIFIC INFLAMMATORY TRANSCRIPTIONAL STATES IN ULCERATIVE COLITIS INDUCTION THERAPY

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January 2023 BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE

Pathophysiology of severe asthma : What are the molecular targets for biotherapies?

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December 2022 PLOS ONE

Proteomic profiling of serum identifies a molecular signature that correlates with clinical outcomes in COPD

Authors : Rania Dagher, Paul Fogel, Jingya Wang, David Soussan, Chia-Chien Chiang, Jennifer Kearley, Daniel Muthas, Camille Taillé, Patrick Berger, Arnaud Bourdin, Cécile Chenivesse, Sylvie Leroy, Gary Anderson, Alison A. Humbles, Michel Aubier, Roland Kolbeck, Marina Pretolani, on behalf of the COBRA Consortium
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December 2022 Critical Care

Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients

Authors : Renaud Prevel, Raphaël Enaud, Arthur Orieux, Adrian Camino, Patrick Berger, Alexandre Boyer, Laurence Delhaes, Didier Gruson
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October 2022 Surgical Endoscopy

Laparoscopic fundoplication for para-oesophageal hernia repair improves respiratory function in patients with dyspnoea: a prospective cohort study

Authors : Damien Bouriez, Yaniss Belaroussi, Mehdi Boubaddi, Paul Martre, Haythem Najah, Patrick Berger, Caroline Gronnier, Denis Collet
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September 2022 Cells

Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism

Authors : Clément Bouchet, Guillaume Cardouat, Matthieu Douard, Florence Coste, Paul Robillard, Frédéric Delcambre, Thomas Ducret, Jean-François Quignard, Pierre Vacher, Isabelle Baudrimont, Roger Marthan, Patrick Berger, Christelle Guibert, Véronique Freund-Michel
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July 2022 Cells

Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca2+ Influx and Akt-eNOS Pathway

Authors : Thais Porto Ribeiro, Solène Barbeau, Isabelle Baudrimont, Pierre Vacher, Véronique Freund-Michel, Guillaume Cardouat, Patrick Berger, Christelle Guibert, Thomas Ducret, Jean-François Quignard
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July 2022 Proceedings of the National Academy of Sciences

Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction

Authors : Guillaume Beucher, Marie-Lise Blondot, Alexis Celle, Noémie Pied, Patricia Recordon-Pinson, Pauline Esteves, Muriel Faure, Mathieu Métifiot, Sabrina Lacomme, Denis Dacheux, Derrick R. Robinson, Gernot Längst, Fabien Beaufils, Marie-Edith Lafon, Patrick Berger, Marc Landry, Denis Malvy, Thomas Trian, Marie-Line Andreola, Harald Wodrich
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July 2022 Biomolecules

Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia

Authors : Solène Barbeau, Alexandre Joushomme, Yann Chappe, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Patrick Berger, Pierre Vacher, Yann Percherancier, Jean-François Quignard, Thomas Ducret
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July 2022 Journal of Allergy and Clinical Immunology

Rhinovirus infection of bronchial epithelium induces specific bronchial smooth muscle cell migration of severe asthmatic patients

Authors : Alexis Celle, Pauline Esteves, Guillaume Cardouat, Fabien Beaufils, Edmée Eyraud, Isabelle Dupin, Elise Maurat, Sabrina Lacomme, Olga Ousova, Hugues Begueret, Matthieu Thumerel, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger, Thomas Trian
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May 2022 Revue des Maladies Respiratoires

Principaux messages de la première Biennale BPCO 2021 de la SPLF. Mieux comprendre pour innover

Authors : J. Ancel, M. Guecamburu, V. Marques Da Silva, P. Schilfarth, L. Boyer, C. Pilette, C. Martin, P. Devillier, P. Berger, M. Zysman, O. Le Rouzic, J. Gonzalez-Bermejo, B. Degano, P.-R. Burgel, E. Ahmed, N. Roche, G. Deslee
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April 2022 Antioxidants

NiONP-Induced Oxidative Stress and Mitochondrial Impairment in an In Vitro Pulmonary Vascular Cell Model Mimicking Endothelial Dysfunction

Authors : Ophélie Germande, Thomas Ducret, Jean-Francois Quignard, Juliette Deweirdt, Véronique Freund-Michel, Marie-Hélène Errera, Guillaume Cardouat, Pierre Vacher, Bernard Muller, Patrick Berger, Christelle Guibert, Magalie Baudrimont, Isabelle Baudrimont
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March 2022 Cell Reports

Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epithelium

Authors : Pauline Esteves, Benoit Allard, Alexis Celle, Isabelle Dupin, Elise Maurat, Olga Ousova, Matthieu Thumerel, Jean-William Dupuy, Thierry Leste-Lasserre, Roger Marthan, Pierre-Olivier Girodet, Thomas Trian, Patrick Berger
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March 2022 European Respiratory Journal

Artificial intelligence in computed tomography for quantifying lung changes in the era of CFTR modulators

Authors : Gael Dournes, Chase S. Hall, Matthew M. Willmering, Alan S. Brody, Julie Macey, Stephanie Bui, Baudouin Denis de Senneville, Patrick Berger, François Laurent, Ilyes Benlala, Jason C. Woods
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January 2022 Frontiers in Pharmacology

Muscarinic receptor M3 activation promotes fibrocytes contraction

Authors : Henrot, P., Eyraud, E., Maurat, E., Point, S., Cardouat, G., Quignard, J.-F., Esteves, P., Trian, T., Girodet, P.-O., Marthan, R., Zysman, M., Berger, P., Dupin, I.
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January 2022 European Respiratory Journal

Evaluation of bronchial wall thickness in asthma using magnetic resonance imaging

Authors : Ilyes Benlala, Gaël Dournes, Pierre-Olivier Girodet, Thomas Benkert, François Laurent, Patrick Berger
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January 2022 ANNALS OF TRANSLATIONAL MEDICINE

Increased airway smooth muscle cells in asthma: mechanisms and therapeutic prospects

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January 2022 bioRxiv

Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

Authors : Eyraud, E., Maurat, E., Sac-Epée, J.-M., Henrot, P., Zysman, M., Esteves, P., Trian, T., Bégueret, H., Girodet, P.-O., Thumerel, M., Hustache-Castaing, R., Marthan, R., Levet, F., Vallois, P., Contin-Bordes, C., Berger, P., Dupin, I.
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January 2022 ALLERGOLOGIE

Dupilumab long-term efficacy in patients with asthma with or without comorbid chronic rhinosinusitis/nasal polyposis enrolled in LIBERTY ASTHMA TRAVERSE from phase 2b study

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January 2022 ALLERGOLOGIE

Dupilumab long-term efficacy in patients with asthma with or without comorbid chronic rhinosinusitis/nasal polyposis enrolled in LIBERTY ASTHMA TRAVERSE from phase 2b study

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January 2022 AMERICAN JOURNAL OF GASTROENTEROLOGY

Differential and Combinatorial Mechanism of Action of Golimumab and Guselkumab in Ulcerative Colitis Induction Therapy: IL-23 Blockade Drives Restoration of Normal Epithelium and Mucosal Healing

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January 2022 JOURNAL OF ASTHMA

Is CCL18 a potential biomarker of type-2 asthma endotypes?

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December 2021 European Respiratory Journal

Circulating fibrocytes as a new tool to predict lung cancer progression after surgery?

Authors : Pauline Henrot, Fabien Beaufils, Matthieu Thumerel, Edmée Eyraud, Augustin Boudoussier, Hugues Begueret, Elise Maurat, Pierre-Olivier Girodet, Roger Marthan, Patrick Berger, Isabelle Dupin, Maéva Zysman
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April 2021 The European respiratory journal

Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling.

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April 2021 The Journal of allergy and clinical immunology

Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers.

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January 2021 ERJ OPEN RESEARCH

Individual trajectory-based care for COPD: getting closer, but not there yet

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January 2021 medRxiv

Contractile cell apoptosis regulates airway smooth muscle remodeling in asthma

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January 2021 EUROPEAN RESPIRATORY JOURNAL

Analysis of spontaneous breathing can predict abnormal lung function in asthma

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January 2021 EUROPEAN RESPIRATORY JOURNAL

Human rhinovirus induce specific bronchial smooth muscle migration toward bronchial epithelium in severe asthma through the CXCL10/CXCR3 axis

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January 2021 EUROPEAN RESPIRATORY JOURNAL

Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers

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January 2021 EUROPEAN RESPIRATORY JOURNAL

Bronchial smooth muscle of severe asthmatic patients decreases rhinovirus replication within the epithelium through a CCL-20/PKR/eIF2-a dependent pathway

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January 2021 EUROPEAN RESPIRATORY JOURNAL

Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodeling

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January 2021 EUROPEAN RESPIRATORY JOURNAL

Short-range interactions between fibrocytes and CD8+T cells modulate the balance between tissue repair and destruction in COPD

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January 2021 EUROPEAN RESPIRATORY JOURNAL

Bronchial remodeling-based latent class analysis predicts exacerbations in severe preschool wheezers

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January 2021 ARTHRITIS & RHEUMATOLOGY

Suppression of Serum Interferon-γ Levels as a Potential Measure of Response to Ustekinumab Treatment in Patients With Systemic Lupus Erythematosus

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December 2020 The journal of allergy and clinical immunology. In practice

Factors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort.

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November 2020 Journal of magnetic resonance imaging : JMRI

Quantification of MRI T2 Interstitial Lung Disease Signal-Intensity Volume in Idiopathic Pulmonary Fibrosis: A Pilot Study.

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September 2020 The Journal of allergy and clinical immunology

Type 2-high asthma is associated with a specific indoor mycobiome and microbiome.

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July 2020 Clinical & Experimental Allergy

Effectiveness and safety of dupilumab for the treatment of severe asthma in a real‐life French multi‐centre adult cohort

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July 2020 BMJ open

Prioritising outcomes for evaluating eosinophil-guided corticosteroid therapy among patients with acute COPD exacerbations requiring hospitalisation: a Delphi consensus study.

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May 2020 European radiology

Volumetric quantification of lung MR signal intensities using ultrashort TE as an automated score in cystic fibrosis.

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March 2020 The European respiratory journal

Connexin-43 is a promising target for pulmonary hypertension due to hypoxaemic lung disease.

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March 2020 Revue des Maladies Respiratoires

La mitochondrie du muscle lisse bronchique : une nouvelle cible thérapeutique dans l’asthme?

Authors : P. Esteves, A. Celle, P. Berger, T. Trian
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February 2020 Scientific reports

Respiratory mycobiome and suggestion of inter-kingdom network during acute pulmonary exacerbation in cystic fibrosis.

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February 2020 European respiratory review : an official journal of the European Respiratory Society

How can we minimise the use of regular oral corticosteroids in asthma?

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January 2020 American journal of physiology. Lung cellular and molecular physiology

Bnip3 as a potential target to treat airway smooth muscle remodeling in asthma?

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January 2020 EUROPEAN RESPIRATORY JOURNAL

The burden of emphysema on lung cancer prognosis

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January 2020 EUROPEAN RESPIRATORY JOURNAL

A high probability of short-range interactions between fibrocytes and CD8+T cells potentiates the inflammatory response in chronic obstructive pulmonary disease (COPD) lungs

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January 2020 EUROPEAN RESPIRATORY JOURNAL

Is CCL18 a potential biomarker of type-2 asthma?

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January 2020 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The first-in-human study of CNTO 7160, an anti-interleukin-33 receptor monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis

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January 2020 EUROPEAN RESPIRATORY REVIEW

How can we minimise the use of regular oral corticosteroids in asthma? (vol 29, 190085, 2020)

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October 2019 Radiology

Quantification of MRI T2-weighted High Signal Volume in Cystic Fibrosis: A Pilot Study.

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September 2019 Respiratory research

Determination of reliable lung function parameters in intubated mice.

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September 2019 The European respiratory journal

Fibrocyte accumulation in the airway walls of COPD patients.

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September 2019 International journal of chronic obstructive pulmonary disease

Assessing pulmonary hypertension in COPD. Is there a role for computed tomography?

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June 2019 International journal of molecular sciences

Chemokines in COPD: From Implication to Therapeutic Use.

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June 2019 Radiology

Automated Volumetric Quantification of Emphysema Severity by Using Ultrashort Echo Time MRI: Validation in Participants with Chronic Obstructive Pulmonary Disease.

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May 2019 Journal of clinical medicine

Intestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn’s-Like Microbiota Disturbances.

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March 2019 Eleventh International Conference on Machine Vision (ICMV 2018)

3D human airway segmentation from high hesolution MR imaging

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February 2019 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

CT evaluation of hyperattenuating mucus to diagnose allergic bronchopulmonary aspergillosis in the special condition of cystic fibrosis.

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February 2019 International journal of chronic obstructive pulmonary disease

Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension.

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January 2019 Frontiers in immunology

Asthmatic Bronchial Smooth Muscle Increases CCL5-Dependent Monocyte Migration in Response to Rhinovirus-Infected Epithelium.

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January 2019 EUROPEAN RESPIRATORY JOURNAL

Ventilometry: a new assessment of respiratory function based on tidal breathing

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January 2019 EUROPEAN RESPIRATORY JOURNAL

A high probability of short-range interactions between fibrocytes and CD8 T cells in chronic obstructive pulmonary disease (COPD) lungs

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January 2019 JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

REDUCTION OF SERUM IL17F AND IL22 BY IL23P19 BLOCKADE WITH GUSELKUMAB IS ASSOCIATED WITH IMPROVEMENT IN JOINT SYMPTOMS IN PSORIATIC ARTHRITIS

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January 2019 LANCET

Guselkumab versus secukinumab for the treatment of moderate-to-severe psoriasis (ECLIPSE): results from a phase 3, randomised controlled trial

Authors :
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January 2019 JOURNAL OF INVESTIGATIVE DERMATOLOGY

Guselkumab Efficacy after Withdrawal Is Associated with Suppression of Serum IL-23-Regulated IL-17 and IL-22 in Psoriasis: VOYAGE 2 Study

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October 2018

Fibrocyte accumulation in bronchi: a cellular hallmark of COPD

Authors : Isabelle Dupin, Matthieu Thumerel, Elise Maurat, Florence Coste, Hugues Begueret, Thomas Trian, Michel Montaudon, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger
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September 2018 Journal of magnetic resonance imaging : JMRI

3D ultrashort echo time MRI of the lung using stack-of-spirals and spherical k-Space coverages: Evaluation in healthy volunteers and parenchymal diseases.

Authors :
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March 2018 Microorganisms

The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis.

Authors :
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March 2018 American journal of respiratory cell and molecular biology

Fibrocytes in Asthma and Chronic Obstructive Pulmonary Disease: Variations on the Same Theme.

Authors :
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March 2018 Pediatric pulmonology

Montelukast reverses airway remodeling in actively sensitized young mice.

Authors :
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January 2018 JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations: A randomized controlled study

Authors :
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January 2018 EUROPEAN RESPIRATORY JOURNAL

Role of quantitative computed tomography in patients with severe precapillary pulmonary hypertension

Authors :
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January 2018 EUROPEAN RESPIRATORY JOURNAL

Phenotype-endotype in very severe preschool wheezers: The P’titAsthme cohort

Authors :
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January 2018 EUROPEAN RESPIRATORY JOURNAL

Bronchial fibrocyte accumulation in COPD patients

Authors :
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January 2018 ARTHRITIS & RHEUMATOLOGY

Reduction of Serum IL17F and IL22 By IL23p19 Blockade with Guselkumab Is Associated with Improvement in Joint Symptoms in Psoriatic Arthritis

Authors :
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January 2018 PEDIATRIC PULMONOLOGY

Phenotype and Endotype Clusters in Very Severe Asthmatic Preschool Children: The P’titasthme Cohort

Authors :
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November 2017 Radiology

Inverted Mucoid Impaction Signal in Allergic Bronchopulmonary Aspergillosis: Are We Calling a Spade a Big Spoon?

Authors :
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October 2017 The European respiratory journal

Combined measurement of carbon monoxide and nitric oxide lung transfer does not improve the identification of pulmonary hypertension in systemic sclerosis.

Authors :
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August 2017 American journal of preventive medicine

Case-Finding for Persistent Airway Obstruction in Farmers: A Questionnaire With Optimal Diagnosis Criteria.

Authors :
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June 2017 Allergy

Lung function parameters in omalizumab responder patients: An interesting tool?

Authors :
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May 2017 Radiology

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis: MR Imaging of Airway Mucus Contrasts as a Tool for Diagnosis.

Authors :
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May 2017 PloS one

Nasal airway epithelial cell IL-6 and FKBP51 gene expression and steroid sensitivity in asthmatic children.

Authors :
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January 2017 Revue de pneumologie clinique

[MRI of the pulmonary parenchyma: Towards clinical applicability?]

Authors :
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January 2017 The Journal of allergy and clinical immunology

Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients.

Authors :
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January 2017 RADIOLOGY

Inverted Mucoid Impaction Signal in Allergic Bronchopulmonary Aspergillosis: Are We Calling a Spade a Big Spoon? Response

Authors :
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January 2017 COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

A Randomized, Placebo-Controlled Phase 2 Trial of CNTO 6785 in Chronic Obstructive Pulmonary Disease

Authors :
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January 2017 PEDIATRIC PULMONOLOGY

Azithromycin Decreases in vitro Bronchial Smooth Muscle (BSM) Cell Proliferation in Severe Pediatric Asthma

Authors :
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December 2016 Respiratory research

Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study.

Authors :
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April 2016 Respiratory research

Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study.

Authors :
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April 2016 Thorax

CT evaluation of small pulmonary vessels area in patients with COPD with severe pulmonary hypertension.

Authors :
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April 2016 Radiology

Quiet Submillimeter MR Imaging of the Lung Is Feasible with a PETRA Sequence at 1.5 T.

Authors :
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March 2016 The Journal of allergy and clinical immunology

Reply.

Authors :
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March 2016 American journal of respiratory and critical care medicine

Bronchial Smooth Muscle Remodeling in Nonsevere Asthma.

Authors :
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February 2016 European radiology

Lung morphology assessment of cystic fibrosis using MRI with ultra-short echo time at submillimeter spatial resolution.

Authors :
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January 2016 AMERICAN JOURNAL OF GASTROENTEROLOGY

Assessment of Inflammatory Burden Identifies Crohn’s Disease and Ulcerative Colitis Patient Groups with Different Disease-Driving Pathways and Therapeutic Response to Anti-TNF Treatment

Authors :
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January 2016 RADIOLOGY

Quiet Submillimeter MR Imaging of the Lung Is Feasible with a PETRA Sequence at 1.5 T

Authors :
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January 2016 EUROPEAN RESPIRATORY JOURNAL

COPD or not COPD: Answer in FEV1

Authors :
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December 2015 The Journal of allergy and clinical immunology

Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients.

Authors :
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December 2015 American journal of respiratory and critical care medicine

Excess Risk of Cancer from Computed Tomography Scan Is Small but Not So Low as to Be Incalculable.

Authors :
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November 2015 Respiratory research

Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study.

Authors :
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October 2015 The Journal of allergy and clinical immunology

Blood fibrocytes are recruited during acute exacerbations of chronic obstructive pulmonary disease through a CXCR4-dependent pathway.

Authors :
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October 2015 The European respiratory journal

Prevalence and risk factors for COPD in farmers: a cross-sectional controlled study.

Authors :
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June 2015 Thorax

Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma.

Authors :
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April 2015 American Journal of Respiratory and Critical Care Medicine

Calcium channel blocker reduces airway remodeling in severe asthma. A proof-of-concept study.

Authors :
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March 2015 PloS one

An age-wise comparison of human airway smooth muscle proliferative capacity.

Authors :
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March 2015 Radiology

Quiet Submillimeter MR Imaging of the Lung Is Feasible with a PETRA Sequence at 1.5 T.

Authors :
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March 2015 American journal of respiratory and critical care medicine

House dust mites induce proliferation of severe asthmatic smooth muscle cells via an epithelium-dependent pathway.

Authors :
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January 2015 American journal of respiratory and critical care medicine

What about targeting smooth muscle remodeling in severe asthma?

Authors :
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January 2015 American journal of respiratory and critical care medicine

Computed tomographic measurement of airway remodeling and emphysema in advanced chronic obstructive pulmonary disease. Correlation with pulmonary hypertension.

Authors :
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January 2015 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased Bronchial Smooth Muscle Mass And Mitochondrial Biogenesis In Non-Severe Asthma

Authors :
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January 2015 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Double-Blind, Placebo-Controlled Trial Of Gallopamil For Severe Asthma

Authors :
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January 2015 INTERNATIONAL JOURNAL OF TOXICOLOGY

Unexpected Toxicology Findings in Rats Dosed With an Antihuman IL-13 Monoclonal Antibody

Authors :
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January 2015 PULMONARY PHARMACOLOGY & THERAPEUTICS

Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease

Authors :
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January 2015 EUROPEAN RESPIRATORY JOURNAL

Clinical biomarkers identify T-helper 2 status defined by mucosal CCL26 in the ADEPT-asthma study

Authors :
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January 2015 EUROPEAN RESPIRATORY JOURNAL

Inflammatory serum profiles are consistent across independent exacerbations in COPD patients with a history of frequent exacerbations

Authors :
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January 2015 EUROPEAN RESPIRATORY JOURNAL

Increased interferon and decreased NRF2-PPARG signaling is associated with frequent exacerbations in COPD

Authors :
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January 2015 EUROPEAN RESPIRATORY JOURNAL

A marine ovalbumin model exhibits molecular features of steroid insensitive human asthma

Authors :
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November 2014 Revue des maladies respiratoires

Contribution of exhaled nitric oxide measurement in airway inflammation assessment in asthma. A position paper from the French Speaking Respiratory Society.

Authors :
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May 2014 The Journal of allergy and clinical immunology

Bronchi wall and lumen volumes to assess airway remodeling in asthma by using CT: an innovative method?

Authors :
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March 2014

Breathing variability and brainstem serotonergic loss in a genetic model of multiple system atrophy.

Authors : Flabeau O, Meissner WG, Ozier A, Berger P, Tison F, Fernagut PO
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February 2014 PloS one

Protease activated receptor-2 expression and function in asthmatic bronchial smooth muscle.

Authors :
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January 2014 EUROPEAN RESPIRATORY JOURNAL

A peripheral HRV-46-driven fingerprint is enriched in severe asthma patients in absence of an active exacerbation

Authors :
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January 2014 EUROPEAN RESPIRATORY JOURNAL

Role of mitochondrial biogenesis in asthmatic airway smooth muscle proliferation: Forever young

Authors :
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January 2014 EUROPEAN RESPIRATORY JOURNAL

Common variable immunodeficiency characteristic: T -cell activation, exhaled nitric oxide, and high -resolution computed tomography

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January 2014 EUROPEAN RESPIRATORY JOURNAL

Common variable immunodeficiency characteristic: T-cell activation, exhaled nitric oxide, and high-resolution computed tomography

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January 2014 EUROPEAN RESPIRATORY JOURNAL

Measurement of small pulmonary vessels by using computed tomography (CT) in COPD patients with severe pulmonary hypertension

Authors :
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January 2014 PEDIATRIC PULMONOLOGY

ROLE OF MITOCHONDRIAL BIOGENESIS IN ASTHMATIC AIRWAY SMOOTH MUSCLE PROLIFERATION: FOREVER YOUNG

Authors :
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January 2014 MOVEMENT DISORDERS

Breathing Variability and Brainstem Serotonergic Loss in a Genetic Model of Multiple System Atrophy

Authors :
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August 2013 Chest

A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma.

Authors :
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August 2013

Adaptative capacity of mitochondrial biogenesis and of mitochondrial dynamics in response to pathogenic respiratory chain dysfunction.

Authors : Benard G, Trian T, Bellance N, Berger P, Lavie J, Espil-Taris C, Rocher C, Eimer-Bouillot S, Goizet C, Nouette-Gaulain K, Letellier T, Lacombe D, Rossignol R
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January 2013

Airway compliance studied by lumen area changes alone cannot discriminate between collapsibility and elasticity.

Authors : Dournes G, Berger P, Laurent F
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January 2013 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway Compliance Studied by Lumen Area Changes Alone Cannot Discriminate between Collapsibility and Elasticity

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January 2013 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Central Airway Mechanic Properties Assessed By Using CT In Severe Asthmatic Individuals With And Without Persistent Obstruction: Comparison With Healthy Volunteers And Correlation With Lung Function

Authors :
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January 2013 EUROPEAN RESPIRATORY JOURNAL

ADEPT, airway disease endotyping for personalized treatment: Interim analysis of asthma patients

Authors :
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January 2013 EUROPEAN RESPIRATORY JOURNAL

The role of fibrocytes in bronchial remodelling during acute exacerbation of COPD

Authors :
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December 2012

CT attenuation of the bronchial wall in patients with asthma: comparison with geometric parameters and correlation with function and histologic characteristics.

Authors : Lederlin M, Laurent F, Portron Y, Ozier A, Cochet H, Berger P, Montaudon M
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November 2012 American journal of respiratory cell and molecular biology

Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model.

Authors :
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September 2012

Airway smooth muscle in asthma: just a target for bronchodilation?

Authors : Black JL, Panettieri RA Jr, Banerjee A, Berger P
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September 2012

Comments on Point:Counterpoint: Alterations in airway smooth muscle phenotype do/do not cause airway hyperresponsiveness in asthma.

Authors : Bosse Y, Vagula MC, Rawding RS, Pun M, Black JL, Burgess J, Oliver B, Berger P, Marthan R, Adner M
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April 2012

Mean bronchial wall attenuation value in chronic obstructive pulmonary disease: comparison with standard bronchial parameters and correlation with function.

Authors : Lederlin M, Laurent F, Dromer C, Cochet H, Berger P, Montaudon M
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January 2012

In Vivo Computed Tomography as a Research Tool to Investigate Asthma and COPD: Where Do We Stand?

Authors : Dournes G, Montaudon M, Berger P, Laurent F
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January 2012 PLOS ONE

In Vivo Micro-CT Assessment of Airway Remodeling in a Flexible OVA-Sensitized Murine Model of Asthma

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January 2012 CLINICS IN CHEST MEDICINE

Airway Smooth Muscle in Asthma Just a Target for Bronchodilation?

Authors :
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January 2012 AMERICAN JOURNAL OF ROENTGENOLOGY

CT Attenuation of the Bronchial Wall in Patients With Asthma: Comparison With Geometric Parameters and Correlation With Function and Histologic Characteristics

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January 2012 JOURNAL OF APPLIED PHYSIOLOGY

COMMENTS ON “ALTERATIONS IN AIRWAY SMOOTH MUSCLE PHENOTYPE DO/DO NOT CAUSE AIRWAY HYPERRESPONSIVENESS IN ASTHMA”

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January 2012 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

YKL-40-mediated Interleukin 8 Production May Be Closely Associated with Remodeling of Bronchial Smooth Muscle Cells Reply

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January 2012 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of YKL-40 in Bronchial Smooth Muscle Remodeling in Asthma

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January 2012 AMERICAN JOURNAL OF ROENTGENOLOGY

Mean Bronchial Wall Attenuation Value in Chronic Obstructive Pulmonary Disease: Comparison With Standard Bronchial Parameters and Correlation With Function

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September 2011

Beyond corticosteroids: future prospects in the management of inflammation in COPD.

Authors : Roche N, Marthan R, Berger P, Chambellan A, Chanez P, Aguilaniu B, Brillet PY, Burgel PR, Chaouat A, Devillier P, Escamilla R, Louis R, Mal H, Muir JF, Pérez T, Similowski T, Wallaert B, Aubier M
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May 2011

Arterialization of central pulmonary vein.

Authors : Shah AJ, Jadidi AS, Lederlin M, Berger P, Miyazaki S, Hocini M, Haissaguerre M
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April 2011

[COPD and inflammation: Statement from a French expert group. How to treat inflammation?].

Authors : Roche N, Devillier P, Aguilaniu B, Escamilla R, Wallaert B, Burgel PR, Berger P, Brillet PY, Chambellan A, Chanez P, Chaouat A, Louis R, Mal H, Marthan R, Muir JF, Pérez T, Similowski T, Aubier M
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March 2011

[Pathophysiology of asthma].

Authors : Ozier A, Bara I, Girodet PO, Marthan R, Berger P
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February 2011

[COPD and inflammation: statement from a French expert group. Phenotypes related to inflammation].

Authors : Perez T, Mal H, Aguilaniu B, Brillet PY, Chaouat A, Louis R, Muir JF, Similowski T, Berger P, Burgel PR, Chambellan A, Chanez P, Devillier P, Escamilla R, Marthan R, Wallaert B, Aubier M, Roche N
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January 2011

The pivotal role of airway smooth muscle in asthma pathophysiology.

Authors : Ozier A, Allard B, Bara I, Girodet PO, Trian T, Marthan R, Berger P
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January 2011

β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.

Authors : Trian T, Burgess JK, Niimi K, Moir LM, Ge Q, Berger P, Liggett SB, Black JL, Oliver BG
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January 2011 EUROPEAN RESPIRATORY REVIEW

Beyond corticosteroids: future prospects in the management of inflammation in COPD

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January 2011 REVUE DES MALADIES RESPIRATOIRES

COPD and inflammation: Statement from a French expert group. How to treat inflammation?

Authors :
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January 2011 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Arterialization of Central Pulmonary Vein

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January 2011 FUNDAMENTAL & CLINICAL PHARMACOLOGY

Potassium channel KCa3.1 inhibition attenuates hyperresponsiveness and allergic airway inflammation

Authors :
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January 2011 FUNDAMENTAL & CLINICAL PHARMACOLOGY

Assessment of bronchial remodelling in vivo by micro-computed tomography in mouse asthma models

Authors :
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January 2011 PHARMACOLOGY & THERAPEUTICS

Airway remodeling in asthma: New mechanisms and potential for pharmacological intervention

Authors :
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January 2011 REVUE DES MALADIES RESPIRATOIRES

COPD and inflammation: Statement from a French expert group. Phenotypes related to inflammation

Authors :
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January 2011 RESPIRATORY MEDICINE

Control maintenance can be predicted by exhaled NO monitoring in asthmatic patients

Authors :
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December 2010

[COPD and inflammation: statement from a French expert group: inflammation and remodelling mechanisms].

Authors : Aubier M, Marthan R, Berger P, Chambellan A, Chanez P, Aguilaniu B, Brillet PY, Burgel PR, Chaouat A, Devillier P, Escamilla R, Louis R, Mal H, Muir JF, Pérez T, Similowski T, Wallaert B, Roche N
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November 2010

Pathophysiology of bronchial smooth muscle remodelling in asthma.

Authors : Bara I, Ozier A, Tunon de Lara JM, Marthan R, Berger P
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January 2010

Airway remodeling in a mouse asthma model assessed by in-vivo respiratory-gated micro-computed tomography.

Authors : Lederlin M, Ozier A, Montaudon M, Begueret H, Ousova O, Marthan R, Berger P, Laurent F
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January 2010 REVUE DES MALADIES RESPIRATOIRES

COPD and inflammation: Statement from a French expert group: Inflammation and remodelling mechanisms

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January 2010 EUROPEAN RESPIRATORY JOURNAL

Pathophysiology of bronchial smooth muscle remodelling in asthma

Authors :
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January 2010 ALLERGY

Mast cell adhesion to bronchial smooth muscle in asthma specifically depends on CD51 and CD44 variant 6

Authors :
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January 2010 EUROPEAN RADIOLOGY

Airway remodeling in a mouse asthma model assessed by in-vivo respiratory-gated micro-computed tomography

Authors :
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December 2009

Bronchial measurements in patients with asthma: comparison of quantitative thin-section CT findings with those in healthy subjects and correlation with pathologic findings.

Authors : Montaudon M, Lederlin M, Reich S, Begueret H, Tunon-de-Lara JM, Marthan R, Berger P, Laurent F
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June 2009

Bronchial morphometry in smokers: comparison with healthy subjects by using 3D CT.

Authors : Montaudon M, Berger P, Lederlin M, Marthan R, Tunon-de-Lara JM, Laurent F
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January 2009 RADIOLOGY

Bronchial Measurements in Patients with Asthma: Comparison of Quantitative Thin-Section CT Findings with Those in Healthy Subjects and Correlation with Pathologic Findings

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January 2009 EUROPEAN RADIOLOGY

Bronchial morphometry in smokers: comparison with healthy subjects by using 3D CT

Authors :
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August 2008

Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6.

Authors : Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P
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January 2008 FASEB JOURNAL

Fibrocyte, CD13+Monocyte and CXCR4+/Col+ Macrophage Infiltrates in a Murine Pulmonary Model of Fibrosis Detected Using 8-color Flow Cytometry

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January 2008 AIRWAY SMOOTH MUSCLE IN ASTHMA AND COPD: BIOLOGY AND PHARMACOLOGY

Airway smooth muscle interaction with mast cells

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January 2008 JOURNAL OF IMMUNOLOGY

Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: Cooperative roles for CADM1, stem cell factor, and IL-6

Authors :
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November 2007

Assessment of bronchial wall thickness and lumen diameter in human adults using multi-detector computed tomography: comparison with theoretical models.

Authors : Montaudon M, Desbarats P, Berger P, de Dietrich G, Marthan R, Laurent F
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February 2007

Assessment of airways with three-dimensional quantitative thin-section CT: in vitro and in vivo validation.

Authors : Montaudon M, Berger P, de Dietrich G, Braquelaire A, Marthan R, Tunon-de-Lara JM, Laurent F
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February 2007

Bronchial measurement with three-dimensional quantitative thin-section CT in patients with cystic fibrosis.

Authors : Montaudon M, Berger P, Cangini-Sacher A, de Dietrich G, Tunon-de-Lara JM, Marthan R, Laurent F
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February 2007

Omalizumab decreases nonspecific airway hyperresponsiveness in vitro.

Authors : Berger P, Scotto-Gomez E, Molimard M, Marthan R, Le Gros V, Tunon-de-Lara JM
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January 2007

Inflammation of bronchial smooth muscle in allergic asthma.

Authors : Begueret H, Berger P, Vernejoux JM, Dubuisson L, Marthan R, Tunon-de-Lara JM
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January 2007 JOURNAL OF EXPERIMENTAL MEDICINE

Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma

Authors :
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January 2007 FASEB JOURNAL

An expression model for the fusion protein of pneumonia virus of mice

Authors :
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January 2007 VIROLOGY

Diminished inflammatory responses to natural pneumovirus infection among older mice

Authors :
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January 2007 JOURNAL OF ANATOMY

Assessment of bronchial wall thickness and lumen diameter in human adults using multi-detector computed tomography: comparison with theoretical models

Authors :
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January 2007 RADIOLOGY

Assessment of airways with three-dimensional quantitative thin-section CT: In vitro and in vivo validation

Authors :
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January 2007 RADIOLOGY

Bronchial measurement with three-dimensional quantitative thin-section CT in patients with cystic fibrosis

Authors :
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January 2007 ALLERGY

Omalizumab decreases nonspecific airway hyperresponsiveness in vitro

Authors :
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January 2007 THORAX

Inflammation of bronchial smooth muscle in allergic asthma

Authors :
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December 2006

Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma.

Authors : Kaur D, Saunders R, Berger P, Siddiqui S, Woodman L, Wardlaw A, Bradding P, Brightling CE
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October 2006

Measurement of cardiac ventricular volumes using multidetector row computed tomography: comparison of two- and three-dimensional methods.

Authors : Montaudon M, Laffon E, Berger P, Corneloup O, Latrabe V, Laurent F
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February 2006 American journal of physiology. Lung cellular and molecular physiology

Increased secretion of leukemia inhibitory factor by immature airway smooth muscle cells enhances intracellular signaling and airway contractility.

Authors :
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January 2006 REVUE DES MALADIES RESPIRATOIRES

Role of the mitochondria in the remodelling of the smooth bronchial muscle in severely asthmatic patients

Authors :
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January 2006 REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE

Imaging in the assessment of airways diseases

Authors :
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January 2006 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma

Authors :
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January 2006 EUROPEAN RADIOLOGY

Measurement of cardiac ventricular volumes using multidetector row computed tomography: comparison of two- and three-dimensional methods

Authors :
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January 2006 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

RNA interference decreases PAR-2 expression and function in human airway smooth muscle cells

Authors :
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January 2006 JOURNAL OF IMMUNOLOGY

Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma

Authors :
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September 2005

Chymase-positive mast cells: a double-edged sword in asthma?

Authors : Tunon-de-Lara JM, Berger P, Marthan R
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June 2005

Airway wall thickness in cigarette smokers: quantitative thin-section CT assessment.

Authors : Berger P, Perot V, Desbarats P, Tunon-de-Lara JM, Marthan R, Laurent F
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May 2005

Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration.

Authors : Brightling CE, Kaur D, Berger P, Morgan AJ, Wardlaw AJ, Bradding P
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April 2005

Increased relaxation of immature airways to beta2-adrenoceptor agonists is related to attenuated expression of postjunctional smooth muscle muscarinic M2 receptors.

Authors : Fayon M, Dumas De La Roque E, Berger P, Begueret H, Ousova O, Molimard M, Marthan R
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April 2005

Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin.

Authors : Guyot N, Zani ML, Berger P, Dallet-Choisy S, Moreau T
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February 2005

Co-cultivation of mast cells and Fc epsilon RI alpha+ dendritic-like cells from human hip bone marrow.

Authors : Kaur D, Berger P, Duffy SM, Brightling CE, Bradding P
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January 2005 JOURNAL OF LEUKOCYTE BIOLOGY

Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration

Authors :
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January 2005 CLINICAL AND EXPERIMENTAL ALLERGY

Co-cultivation of mast cells and FcεRIα+ dendritic-like cells from human hip bone marrow

Authors :
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January 2005 JOURNAL OF APPLIED PHYSIOLOGY

Increased relaxation of immature airways to β2-adrenoceptor agonists is related to attenuated expression of postjunctional smooth muscle muscarinic M2 receptors

Authors :
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January 2005 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chymase-positive mast cells: A double-edged sword in asthma?

Authors :
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January 2005 ALLERGY

Mast cell myositis: a new feature of allergic asthma?

Authors :
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January 2005 FUNDAMENTAL & CLINICAL PHARMACOLOGY

Paradoxal effect of salbutamol in an in vitro model of bronchoprotection

Authors :
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January 2005 RADIOLOGY

Airway wall thickness in cigarette smokers: Quantitative thin-section CT assessment

Authors :
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January 2005 BIOLOGICAL CHEMISTRY

Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin

Authors :
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July 2004

The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells.

Authors : Mark Duffy S, Berger P, Cruse G, Yang W, Bolton SJ, Bradding P
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January 2004 JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells

Authors :
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November 2003

Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis.

Authors : Berger P, Girodet PO, Begueret H, Ousova O, Perng DW, Marthan R, Walls AF, Tunon de Lara JM
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July 2003

Structure and function of small airways in smokers: relationship between air trapping at CT and airway inflammation.

Authors : Berger P, Laurent F, Begueret H, Perot V, Rouiller R, Raherison C, Molimard M, Marthan R, Tunon-de-Lara JM
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July 2003

Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation.

Authors : Taillé C, Almolki A, Benhamed M, Zedda C, Mégret J, Berger P, Lesèche G, Fadel E, Yamaguchi T, Marthan R, Aubier M, Boczkowski J
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April 2003

[Anti-IgE and future treatments for respiratory allergies].

Authors : Tunon-De-Lara JM, Raherison C, Berger P
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January 2003 FASEB JOURNAL

Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis

Authors :
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January 2003 JOURNAL OF BIOLOGICAL CHEMISTRY

Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation

Authors :
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January 2003 RADIOLOGY

Structure and function of small airways in smokers: Relationship between air trapping at CT and airway inflammation

Authors :
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December 2002

[The pathophysiological role of smooth muscle cells in bronchial inflammation]

Authors : Berger P, Marthan R, Tunon de Lara JM
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September 2002

Mast cells in airway smooth muscle.

Authors : Tunon-de-Lara JM, Berger P, Bégueret H
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July 2002

Passive sensitization of human airways induces mast cell degranulation and release of tryptase.

Authors : Berger P, N'guyen C, Buckley M, Scotto-Gomez E, Marthan R, Tunon-de-Lara JM
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February 2002

Pharmacologically induced relaxation of tracheal smooth muscle is increased in hyperoxia-exposed 15-day-old rats.

Authors : Fayon MJ, Denis D, Molimard M, Berger P, Choukroun ML, Demarquez JL, Marthan R, Clevel H, Lachaud JL, Martinez B, Téchoueyres P
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January 2002 PEDIATRIC PULMONOLOGY

Pharmacologically induced relaxation of tracheal smooth muscle is increased in hyperoxia-exposed 15-day-old rats

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January 2002 REVUE DES MALADIES RESPIRATOIRES

The pathophysiological role of smooth muscle cells in bronchial inflammation

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January 2002 ALLERGY

Passive sensitization of human airways induces mast cell degranulation and release of tryptase

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January 2002 NEW ENGLAND JOURNAL OF MEDICINE

Mast cells in airway smooth muscle.

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November 2001

Estradiol decreases the acetylcholine-elicited airway reactivity in ovariectomized rats through an increase in epithelial acetylcholinesterase activity.

Authors : Degano B, Prévost MC, Berger P, Molimard M, Pontier S, Rami J, Escamilla R
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October 2001

Prolonged moderate hyperoxia induces hyperresponsiveness and airway inflammation in newborn rats.

Authors : Denis D, Fayon MJ, Berger P, Molimard M, De Lara MT, Roux E, Marthan R
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September 2001

Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells.

Authors : Berger P, Perng DW, Thabrew H, Compton SJ, Cairns JA, McEuen AR, Marthan R, Tunon De Lara JM, Walls AF
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August 2001

Selected contribution: tryptase-induced PAR-2-mediated Ca(2+) signaling in human airway smooth muscle cells.

Authors : Berger P, Tunon-De-Lara JM, Savineau JP, Marthan R
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January 2001

Thin-section CT of the lung: influence of 0.5-s gantry rotation and ECG triggering on image quality.

Authors : Montaudon M, Berger P, Blachère H, De Boucaud L, Latrabe V, Laurent F
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January 2001 JOURNAL OF APPLIED PHYSIOLOGY

Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells

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January 2001 PEDIATRIC RESEARCH

Prolonged moderate hyperoxia induces hyperresponsiveness and airway inflammation in newborn rats

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January 2001 EUROPEAN RADIOLOGY

Thin-section CT of the lung: influence of 0.5-s gantry rotation and ECG triggering on image quality

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January 2001 JOURNAL OF APPLIED PHYSIOLOGY

Signal transduction in smooth muscle -: Selected contribution:: Tryptase-induced PAR-2-mediated Ca2+ signaling in human airway smooth muscle cells

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January 2001 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Estradiol decreases the acetylcholine-elicited airway reactivity in ovariectomized rats through an increase in epithelial acetylcholinesterase activity

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September 2000

Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer or doxycycline aggravates pulmonary hypertension in rats.

Authors : Vieillard-Baron A, Frisdal E, Eddahibi S, Deprez I, Baker AH, Newby AC, Berger P, Levame M, Raffestin B, Adnot S, d'Ortho MP
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January 2000 CIRCULATION RESEARCH

Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer or doxycycline aggravates pulmonary hypertension in rats

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December 1999

Assessment of bronchial inflammation using an automated cell recognition system based on colour analysis.

Authors : Berger P, Lavallée J, Rouiller R, Laurent F, Marthan R, Tunon-de-Lara JM
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June 1999

Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi.

Authors : Berger P, Compton SJ, Molimard M, Walls AF, N'Guyen C, Marthan R, Tunon-De-Lara JM
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January 1999 EUROPEAN RESPIRATORY JOURNAL

Assessment of bronchial inflammation using an automated cell recognition system based on colour analysis

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January 1999 CLINICAL AND EXPERIMENTAL ALLERGY

Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi

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February 1998

Immunoglobulin E-induced passive sensitization of human airways: an immunohistochemical study.

Authors : Berger P, Walls AF, Marthan R, Tunon-de-Lara JM
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January 1998 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunoglobulin E-induced passive sensitization of human airways – An immunohistochemical study

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January 1995

[Presumed transudative pleural effusion?]

Authors : Berger P, Vernejoux JM, Duclos F, Villanueva P, Taytard A
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January 1995 REVUE DES MALADIES RESPIRATOIRES

A PRESUMED TRANSSUDATIVE PLEURAL EFFUSION

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Team

Team 2

Bronchial remodeling

The study of the mechanisms and treatments of bronchial remodeling in asthma and chronic bronchitis is at the heart of this team's work. It has recognized expertise in epithelium-muscle interactions, functional imaging and clinical research.

Leadership : Patrick BERGER