Pierre VACHER

September 2022 Cells

Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism

Authors : Clément Bouchet, Guillaume Cardouat, Matthieu Douard, Florence Coste, Paul Robillard, Frédéric Delcambre, Thomas Ducret, Jean-François Quignard, Pierre Vacher, Isabelle Baudrimont, Roger Marthan, Patrick Berger, Christelle Guibert, Véronique Freund-Michel

July 2022 Cells

Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca2+ Influx and Akt-eNOS Pathway

Authors : Thais Porto Ribeiro, Solène Barbeau, Isabelle Baudrimont, Pierre Vacher, Véronique Freund-Michel, Guillaume Cardouat, Patrick Berger, Christelle Guibert, Thomas Ducret, Jean-François Quignard

July 2022 Biomolecules

Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia

Authors : Solène Barbeau, Alexandre Joushomme, Yann Chappe, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Patrick Berger, Pierre Vacher, Yann Percherancier, Jean-François Quignard, Thomas Ducret

June 2022 Biomolecules

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network

Authors : Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jérôme Estaquier, Germain Gillet, Isabelle Guénal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stéphen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernard Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Luc Poyet, Muriel Priault, Jean-Ehrland Ricci, Franck B. Riquet, Santos A. Susin, Magali Suzanne, Pierre Vacher, Ludivine Walter, Bertrand Mollereau

April 2022 Antioxidants

NiONP-Induced Oxidative Stress and Mitochondrial Impairment in an In Vitro Pulmonary Vascular Cell Model Mimicking Endothelial Dysfunction

Authors : Ophélie Germande, Thomas Ducret, Jean-Francois Quignard, Juliette Deweirdt, Véronique Freund-Michel, Marie-Hélène Errera, Guillaume Cardouat, Pierre Vacher, Bernard Muller, Patrick Berger, Christelle Guibert, Magalie Baudrimont, Isabelle Baudrimont

April 2022 Cells

Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors

Authors : Gael Galli, Pierre Vacher, Bernhard Ryffel, Patrick Blanco, Patrick Legembre

December 2021 Cells

TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex

Authors : Kelly Airiau, Pierre Vacher, Olivier Micheau, Valerie Prouzet-Mauleon, Guido Kroemer, Mohammad Amin Moosavi, Mojgan Djavaheri-Mergny

November 2021 Cells

Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid

Authors : Faten Merhi, Karla Alvarez-Valadez, Jenifer Trepiana, Claire Lescoat, Alexis Groppi, Jean-William Dupuy, Pierre Soubeyran, Guido Kroemer, Pierre Vacher, Mojgan Djavaheri-Mergny

September 2021 Biomolecules

Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension

Authors : Solène Barbeau, Guillaume Gilbert, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Pierre Vacher, Jean-François Quignard, Thomas Ducret

August 2021 Nature communications

Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.

Authors :

July 2021 Biochimica et biophysica acta. Reviews on cancer

Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target?

Authors :

June 2021 Science translational medicine

Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis.

Authors :

July 2019 Bioorganic & medicinal chemistry letters

Synthesis of peptidomimetics and chemo-biological tools for CD95/PLCγ1 interaction analysis.

Authors :

June 2019 Seminars in cancer biology

CD95/Fas and metastatic disease: What does not kill you makes you stronger.

Authors :

March 2019 Cancers

Role of Calcium Signaling in GA101-Induced Cell Death in Malignant Human B Cells

Authors : Simon Latour, Marion Zanese, Valérie Le Morvan, Anne-Marie Vacher, Nelly Menard, Fontanet Bijou, Francoise Durrieu, Pierre Soubeyran, Ariel Savina, Pierre Vacher, Laurence Bresson-Bepoldin

November 2018 Cancers

The Role of the Anti-Aging Protein Klotho in IGF-1 Signaling and Reticular Calcium Leak: Impact on the Chemosensitivity of Dedifferentiated Liposarcomas

Authors : Vanessa Delcroix, Olivier Mauduit, Nolwenn Tessier, Anaïs Montillaud, Tom Lesluyes, Thomas Ducret, Frédéric Chibon, Fabien Van Coppenolle, Sylvie Ducreux, Pierre Vacher

February 2017 Oncotarget

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress.

Authors : Dufour F, Rattier T, Constantinescu AA, Zischler L, Morlé A, Ben Mabrouk H, Humblin E, Jacquemin G, Szegezdi E, Delacote F, Marrakchi N, Guichard G, Micheau O

January 2017 Biophysical journal

Full-Spectral Multiplexing of Bioluminescence Resonance Energy Transfer in Three TRPV Channels.

Authors : Ruigrok HJ, Shahid G, Goudeau B, Poulletier de Gannes F, Poque-Haro E, Hurtier A, Lagroye I, Vacher P, Arbault S, Sojic N, Veyret B, Percherancier Y

January 2017 CD95

CD95-Mediated Calcium Signaling

Authors : Mehdi Hammadi, Vanessa Delcroix, Anne-Marie Vacher, Thomas Ducret, Pierre Vacher

January 2017 Nature Communications

mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation

Authors : Victor H. Villar, Tra Ly Nguyen, Vanessa Delcroix, Silvia Terés, Marion Bouchecareilh, Bénédicte Salin, Clément Bodineau, Pierre Vacher, Muriel Priault, Pierre Soubeyran, Raúl V. Durán

November 2016 Oncotarget

The antidepressant fluoxetine induces necrosis by energy depletion and mitochondrial calcium overload

Authors : Emilie Charles, Mehdi Hammadi, Philippe Kischel, Vanessa Delcroix, Nicolas Demaurex, Cyril Castelbout, Anne-Marie Vacher, Anne Devin, Thomas Ducret, Paula Nunes, Pierre Vacher

October 2016 Cell death and differentiation

The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca(2+) flux from the endoplasmic reticulum to mitochondria.

Authors : Fouqué A, Lepvrier E, Debure L, Gouriou Y, Malleter M, Delcroix V, Ovize M, Ducret T, Li C, Hammadi M, Vacher P, Legembre P

September 2016 Arthritis & rheumatology (Hoboken, N.J.)

IgE Inhibits Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Expression of Interferon-α by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus.

Authors : Khoryati L, Augusto JF, Shipley E, Contin-Bordes C, Douchet I, Mitrovic S, Truchetet ME, Lazaro E, Duffau P, Couzi L, Jacquemin C, Barnetche T, Fédération Hospitalo-Universitaire ACRONIM

July 2016 Immunity

CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice

Authors : Amanda Poissonnier, Doriane Sanséau, Matthieu Le Gallo, Marine Malleter, Nicolas Levoin, Roselyne Viel, Lucie Morere, Aubin Penna, Patrick Blanco, Alain Dupuy, Florence Poizeau, Alain Fautrel, Julien Seneschal, Florence Jouan, Jerome Ritz, Edouard Forcade, Nathalie Rioux, Cécile Contin-Bordes, Thomas Ducret, Anne-Marie Vacher, Paul A. Barrow, Robin J. Flynn, Pierre Vacher, Patrick Legembre

July 2016 Cancer Research

Abstract 3723: Regulation of TRAIL-induced apoptotic signaling by the autophagy receptor p62 in acute promyelocytic leukemia cells

Authors : Kelly Airiau, Olivier Micheau, Anne-Marie Vacher, Faten Mehri, Pierre Vacher, Mojgan Djavaheri-Mergny

June 2016 Scientific reports

The cleaved FAS ligand activates the Na(+)/H(+) exchanger NHE1 through Akt/ROCK1 to stimulate cell motility.

Authors : Monet M, Poët M, Tauzin S, Fouqué A, Cophignon A, Lagadic-Gossmann D, Vacher P, Legembre P, Counillon L

July 2015 The Journal of Immunology

Localized Store-Operated Calcium Influx Represses CD95-Dependent Apoptotic Effects of Rituximab in Non-Hodgkin B Lymphomas

Authors : Pierre Vacher, Anne-Marie Vacher, Raphael Pineau, Simon Latour, Isabelle Soubeyran, Celine Pangault, Karin Tarte, Pierre Soubeyran, Thomas Ducret, Laurence Bresson-Bepoldin

April 2015 Diabetologia

Multilevel control of glucose homeostasis by adenylyl cyclase 8.

Authors : Raoux M, Vacher P, Papin J, Picard A, Kostrzewa E, Devin A, Gaitan J, Limon I, Kas MJ, Magnan C, Lang J

November 2013 Cancer research

CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer.

Authors : Malleter M, Tauzin S, Bessede A, Castellano R, Goubard A, Godey F, Levêque J, Jézéquel P, Campion L, Campone M, Ducret T, MacGrogan G, Debure L, Legembre P

March 2012 Communicative & Integrative Biology

The CD95 signaling pathway

Authors : Aubin Penna, Nadine Khadra, Sébastien Tauzin, Pierre Vacher, Patrick Legembre

November 2011 Proceedings of the National Academy of Sciences of the United States of America

CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.

Authors : Khadra N, Bresson-Bepoldin L, Penna A, Chaigne-Delalande B, Ségui B, Levade T, Vacher AM, Reiffers J, Ducret T, Moreau JF, Cahalan MD, Vacher P, Legembre P

July 2011 Anti-Cancer Drugs

Does calcium contribute to the CD95 signaling pathway?

Authors : Pierre Vacher, Nadine Khadra, Anne-Marie Vacher, Emilie Charles, Laurence Bresson-Bepoldin, Patrick Legembre

February 2011 Diabetologia

Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.

Authors : Roger B, Papin J, Vacher P, Raoux M, Mulot A, Dubois M, Kerr-Conte J, Voy BH, Pattou F, Charpentier G, Jonas JC, Moustaïd-Moussa N, Lang J

January 2011

The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.

Authors : Sébastien Tauzin, Benjamin Chaigne-Delalande, Eric Selva, Nadine Khadra, Sophie Daburon, Cécile Contin-Bordes, Patrick Blanco, Jacques Le Seyec, Thomas Ducret, Laurent Counillon, Jean-François Moreau, Paul Hofman, Pierre Vacher, Patrick Legembre

October 2010 Bulletin du Cancer

R10: Effets apoptotiques des antidépresseurs de la famille du Prozac

Authors : E. Charles, S. Chanel, A.M. Vacher, A. Devin, P. Vacher

April 2008 Neuroendocrinology

Arachidonic Acid-Induced Hormone Release in Somatotropes: Involvement of Calcium

Authors : Morad M. Roudbaraki, Robert Drouhault, Thierry Bacquart, Pierre Vacher

April 2008 Neuroendocrinology

GnRH-Associated Peptide Decreases Cyclic AMP Accumulation in the GH₃Pituitary Cell Line

Authors : Tràn Vân Chuoï, Pierre Vacher, Bernard Dufy

January 2008 Biophysical Journal

Pore Formation Induced by an Antimicrobial Peptide: Electrostatic Effects

Authors : Frantz Jean-François, Juan Elezgaray, Pascal Berson, Pierre Vacher, Erick J. Dufourc

April 2007 Endocrinology

Glucotoxicity inhibits late steps of insulin exocytosis.

Authors : Dubois M, Vacher P, Roger B, Huyghe D, Vandewalle B, Kerr-Conte J, Pattou F, Moustaïd-Moussa N, Lang J

March 2006 The Journal of biological chemistry

Alpha-latrotoxin induces exocytosis by inhibition of voltage-dependent K+ channels and by stimulation of L-type Ca2+ channels via latrophilin in beta-cells.

Authors : Lajus S, Vacher P, Huber D, Dubois M, Benassy MN, Ushkaryov Y, Lang J

November 2004 Cell Calcium

Role of store-dependent influx of Ca2+ and efflux of K+ in apoptosis of CHO cells

Authors : Delphine Pigozzi, Bertrand Tombal, Thomas Ducret, Pierre Vacher, Philippe Gailly

March 2004 Journal of neurophysiology

Effects of prolactin on ionic membrane conductances in the human malignant astrocytoma cell line U87-MG.

Authors : Ducret T, Vacher AM, Vacher P

October 2003 Molecular Membrane Biology

Voltage-dependent ionic conductances in the human malignant astrocytoma cell line U87-MG

Authors : Thomas Ducret, Anne-marie Vacher, Pierre Vacher

May 2002 ICONO 2001: Novel Trends in Nonlinear Laser Spectroscopy and Optical Diagnostics and Lasers in Chemistry, Biophysics, and Biomedicine

Visualization of intracellular Ca2+dynamics with third-harmonic generation microscopy

Authors : R. Barille, S. Rivet, Lionel Canioni, Laurent Sarger, Pierre Vacher, Pierre Voisin, Andrey Y. Chikishev, Valentin A. Orlovich, Anatoly N. Rubinov, Alexei M. Zheltikov

April 2002 Glia

Effects of prolactin on intracellular calcium concentration and cell proliferation in human glioma cells

Authors : Thomas Ducret, Sihem Boudina, Bruno Sorin, Anne Marie Vacher, Isabelle Gourdou, Dominique Liguoro, Jean Guerin, Laurence Bresson-Bepoldin, Pierre Vacher

April 2001 Optics letters

Imaging of Ca(2)+ intracellular dynamics with a third-harmonic generation microscope.

Authors : Canioni L, Rivet S, Sarger L, Barille R, Vacher P, Voisin P

September 2000 Journal of neuroendocrinology

Role of protein kinases in the prolactin-induced intracellular calcium rise in Chinese hamster ovary cells expressing the prolactin receptor.

Authors : Sorin B, Vacher AM, Djiane J, Vacher P

October 1998 The Journal of biological chemistry

Distinct cytoplasmic regions of the prolactin receptor are required for prolactin-induced calcium entry.

Authors : Sorin B, Goupille O, Vacher AM, Paly J, Djiane J, Vacher P

April 1998 Molecular and Cellular Endocrinology

Tubocurarine blocks a calcium-dependent potassium current in rat tumoral pituitary cells

Authors : P Vacher, A.-M Vacher, P Mollard

September 1996 European journal of endocrinology

17 beta-estradiol stimulates a rapid Ca2+ influx in LNCaP human prostate cancer cells.

Authors : Audy MC, Vacher P, Duly B

April 1996 Journal of biomedical science

Dual Effect of Prolactin on Protein Kinase C Activity in CHO Cells Expressing Functional Prolactin Receptors.

Authors : Audy MC, Vacher P, Vacher AM, Dufy B

April 1996 Endocrine

Spontaneous and agonist-induced calcium oscillations in single human nonfunctioning adenoma cells

Authors : Pierre Vacher, Lawrence Bresson-Bepoldin, Luce Dufy-Barbe, Marie Françoise Odessa, Jean Guerin, Bernard Dufy

October 1995 Journal of biomedical science

The Lipidosterolic Extract fromSerenoa repens Interferes with Prolactin Receptor Signal Transduction.

Authors : Vacher P, Prevarskaya N, Skryma R, Audy MC, Vacher AM, Odessa MF, Dufy B

October 1995 The Journal of biological chemistry

Role of tyrosine phosphorylation in potassium channel activation. Functional association with prolactin receptor and JAK2 tyrosine kinase.

Authors : Prevarskaya NB, Skryma RN, Vacher P, Daniel N, Djiane J, Dufy B

June 1995 The American journal of physiology

Arachidonic acid increases cytosolic calcium and stimulates hormone release in rat lactotrophs.

Authors : Roudbaraki MM, Vacher P, Drouhault R

January 1995 Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Gn-RH agonists in the treatment of prostatic carcinoma.

Authors : Vacher P

December 1994 Molecular and cellular neurosciences

Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C.

Authors : Prevarskaya N, Skryma R, Vacher P, Bresson-Bepoldin L, Odessa MF, Rivel J, San Galli F, Guerin J, Dufy-Barbe L

October 1994 The Journal of biological chemistry

Cytosolic Ca2+ of excitable pituitary cells at resting potentials is controlled by steady state Ca2+ currents sensitive to dihydropyridines.

Authors : Mollard P, Theler JM, Guérineau N, Vacher P, Chiavaroli C, Schlegel W

August 1994 The American journal of physiology

Early effects of PRL on ion conductances in CHO cells expressing PRL receptor.

Authors : Prevarskaya N, Skryma R, Vacher P, Daniel N, Bignon C, Djiane J, Dufy B

August 1994 The American journal of physiology

Voltage-dependent ionic conductances in Chinese hamster ovary cells.

Authors : Skryma R, Prevarskaya N, Vacher P, Dufy B

August 1994 FEBS letters

Voltage-dependent Ca2+ channels in Chinese hamster ovary (CHO) cells.

Authors : Skryma R, Prevarskaya N, Vacher P, Dufy B

July 1994 Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

Prolactin receptor and signal transduction to milk protein genes.

Authors : Djiane J, Daniel N, Bignon C, Paly J, Waters M, Vacher P, Dufy B

March 1994 Endocrinology

Short term effect of prolactin on intracellular calcium in Chinese hamster ovary cells stably transfected with prolactin receptor complementary deoxyribonucleic acid.

Authors : Vacher P, Tran Van Chuoi M, Paly J, Djiane J, Dufy B

September 1993 Molecular and cellular endocrinology

Thyrotropin-releasing hormone and gonadotropin-releasing hormone-associated peptide modulation of [Ca2+]i in human lactotrophs.

Authors : Dufy-Barbe L, Bresson L, Vacher P, Odessa MF, San Galli F, Rivel J, Guérin J

January 1993 Advances in second messenger and phosphoprotein research

Calcium signalling: comparison of the role of Ca2+ influx in excitable endocrine and non-excitable myeloid cells.

Authors : Schlegel W, Mollard P, Demaurex N, Theler JM, Chiavaroli C, Guérineau N, Vacher P, Mayr G, Krause KH, Wollheim CB

November 1992 The American journal of physiology

Complex effects of arachidonic acid and its lipoxygenase products on cytosolic calcium in GH3 cells.

Authors : Vacher P, McKenzie J, Dufy B

October 1992 European Journal of Pharmacology: Molecular Pharmacology

Modulation of Ca2+ influx by protein phosphorylation in single intact clonal pituitary cells

Authors : Carlo Chiavaroli, Pierre Vacher, Werner Schlegel

September 1992 The Journal of biological chemistry

Video imaging of cytosolic Ca2+ in pancreatic beta-cells stimulated by glucose, carbachol, and ATP.

Authors : Theler JM, Mollard P, Guérineau N, Vacher P, Pralong WF, Schlegel W, Wollheim CB

February 1992 The Journal of membrane biology

Calcium-activated chloride conductance of lactotrophs: comparison of activation in normal and tumoral cells during thyrotropin-releasing-hormone stimulation.

Authors : Sartor P, Dufy-Barbe L, Vacher P, Dufy B

August 1991 Journal of immunology (Baltimore, Md. : 1950)

Activation by bacterial lipopolysaccharide causes changes in the cytosolic free calcium concentration in single peritoneal macrophages.

Authors : Letari O, Nicosia S, Chiavaroli C, Vacher P, Schlegel W

June 1991 Journal of neuroendocrinology

Simultaneous monitoring of cytosolic free calcium and exocytosis at the single cell level.

Authors : Chiavaroli C, Vacher P, Vecsey A, Mons N, Letari O, Pralong W, Lagnaux Y, Whelan R, Schlegel W

January 1991 Endocrinology

The gonadotropin-releasing hormone associated peptide reduces calcium entry in prolactin-secreting cells.

Authors : Vacher P, Mariot P, Dufy-Barbe L, Nikolics K, Seeburg PH, Kerdelhue B, Dufy B

January 1991 Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie

[Long-term induced effects by only one treatment with ketoconazole on rat tumoral pituitary cells (GH3/B6 strains)]

Authors : Drouhault R, Vacher P, Darret D, Larrue J, Vacher AM, Vilayleck N

June 1990 The Biochemical journal

Thyrotropin-releasing hormone activates a [Ca2+]i-dependent K+ current in GH3 pituitary cells via Ins(1,4,5)P3-sensitive and Ins(1,4,5)P3-insensitive mechanisms.

Authors : Mollard P, Dufy B, Vacher P, Barker JL, Schlegel W

November 1989 Neuroendocrinology

Differential effects of ketoconazole on prolactin and growth hormone release by normal and tumoral rat anterior pituitary cells in vitro.

Authors : Drouhault R, Vacher P, David JP, Courtes AM, Vilayleck N, Dufy B

August 1989 The American journal of physiology

Arachidonic acid affects membrane ionic conductances of GH3 pituitary cells.

Authors : Vacher P, McKenzie J, Dufy B

March 1989 European journal of pharmacology

Inhibitors of 1,2-diacylglycerol kinase potentiate the TRH-induced stimulation of Ca2+-activated K+ current.

Authors : Mollard P, Vacher P, Dufy B, Winiger BP, Schlegel W

January 1989 Pflugers Archiv : European journal of physiology

Direct evidence for control by cytosolic Ca2+ of K+ currents in pituitary cells.

Authors : Mollard P, Vacher P, Dufy B, Winiger BP, Chiavarolli C, Schlegel W

December 1988 The Journal of biological chemistry

Thyrotropin-releasing hormone-induced rise in cytosolic calcium and activation of outward K+ current monitored simultaneously in individual GH3B6 pituitary cells.

Authors : Mollard P, Vacher P, Dufy B, Winiger BP, Schlegel W

October 1988 FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Vasopressin enhances a calcium current in human ACTH-secreting pituitary adenoma cells.

Authors : Mollard P, Vacher P, Rogawski MA, Dufy B

August 1988 Endocrinology

Somatostatin blocks Ca2+ action potential activity in prolactin-secreting pituitary tumor cells through coordinate actions on K+ and Ca2+ conductances.

Authors : Mollard P, Vacher P, Dufy B, Barker JL

July 1988 Endocrinology

Tamoxifen reduces calcium currents in a clonal pituitary cell line.

Authors : Sartor P, Vacher P, Mollard P, Dufy B

July 1987 Endocrinology

Electrical properties of cultured human adrenocorticotropin-secreting adenoma cells: effects of high K+, corticotropin-releasing factor, and angiotensin II.

Authors : Mollard P, Vacher P, Guerin J, Rogawski MA, Dufy B

January 1987 Comptes rendus des seances de la Societe de biologie et de ses filiales

[Ketoconazole inhibits the conductance K+ induced by thyreoliberin (TRH) in GH3 cells]

Authors : Vacher P, Mollard P, Drouhault R, Dufy B

January 1987 Nature

Oscillations of cytosolic Ca2+ in pituitary cells due to action potentials.

Authors : Schlegel W, Winiger BP, Mollard P, Vacher P, Wuarin F, Zahnd GR, Wollheim CB, Dufy B

Members

Pierre VACHER

Publications 85

Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism

Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca2+ Influx and Akt-eNOS Pathway

Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network

NiONP-Induced Oxidative Stress and Mitochondrial Impairment in an In Vitro Pulmonary Vascular Cell Model Mimicking Endothelial Dysfunction

Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors

TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex

Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid

Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension

Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.

Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target?

Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis.

Synthesis of peptidomimetics and chemo-biological tools for CD95/PLCγ1 interaction analysis.

CD95/Fas and metastatic disease: What does not kill you makes you stronger.

Role of Calcium Signaling in GA101-Induced Cell Death in Malignant Human B Cells

The Role of the Anti-Aging Protein Klotho in IGF-1 Signaling and Reticular Calcium Leak: Impact on the Chemosensitivity of Dedifferentiated Liposarcomas

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress.

Full-Spectral Multiplexing of Bioluminescence Resonance Energy Transfer in Three TRPV Channels.

CD95-Mediated Calcium Signaling

mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation

The antidepressant fluoxetine induces necrosis by energy depletion and mitochondrial calcium overload

The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca(2+) flux from the endoplasmic reticulum to mitochondria.

IgE Inhibits Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Expression of Interferon-α by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus.

CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice

Abstract 3723: Regulation of TRAIL-induced apoptotic signaling by the autophagy receptor p62 in acute promyelocytic leukemia cells

The cleaved FAS ligand activates the Na(+)/H(+) exchanger NHE1 through Akt/ROCK1 to stimulate cell motility.

Localized Store-Operated Calcium Influx Represses CD95-Dependent Apoptotic Effects of Rituximab in Non-Hodgkin B Lymphomas

Multilevel control of glucose homeostasis by adenylyl cyclase 8.

CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer.

The CD95 signaling pathway

CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.

Does calcium contribute to the CD95 signaling pathway?

Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.

The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.

R10: Effets apoptotiques des antidépresseurs de la famille du Prozac

Arachidonic Acid-Induced Hormone Release in Somatotropes: Involvement of Calcium

GnRH-Associated Peptide Decreases Cyclic AMP Accumulation in the GH3 Pituitary Cell Line

Pore Formation Induced by an Antimicrobial Peptide: Electrostatic Effects

Glucotoxicity inhibits late steps of insulin exocytosis.

Alpha-latrotoxin induces exocytosis by inhibition of voltage-dependent K+ channels and by stimulation of L-type Ca2+ channels via latrophilin in beta-cells.

Role of store-dependent influx of Ca2+ and efflux of K+ in apoptosis of CHO cells

Effects of prolactin on ionic membrane conductances in the human malignant astrocytoma cell line U87-MG.

Voltage-dependent ionic conductances in the human malignant astrocytoma cell line U87-MG

Visualization of intracellular Ca2+dynamics with third-harmonic generation microscopy

Effects of prolactin on intracellular calcium concentration and cell proliferation in human glioma cells

Imaging of Ca(2)+ intracellular dynamics with a third-harmonic generation microscope.

Role of protein kinases in the prolactin-induced intracellular calcium rise in Chinese hamster ovary cells expressing the prolactin receptor.

Distinct cytoplasmic regions of the prolactin receptor are required for prolactin-induced calcium entry.

Tubocurarine blocks a calcium-dependent potassium current in rat tumoral pituitary cells

17 beta-estradiol stimulates a rapid Ca2+ influx in LNCaP human prostate cancer cells.

Dual Effect of Prolactin on Protein Kinase C Activity in CHO Cells Expressing Functional Prolactin Receptors.

Spontaneous and agonist-induced calcium oscillations in single human nonfunctioning adenoma cells

The Lipidosterolic Extract fromSerenoa repens Interferes with Prolactin Receptor Signal Transduction.

Role of tyrosine phosphorylation in potassium channel activation. Functional association with prolactin receptor and JAK2 tyrosine kinase.

Arachidonic acid increases cytosolic calcium and stimulates hormone release in rat lactotrophs.

Gn-RH agonists in the treatment of prostatic carcinoma.

Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C.

Cytosolic Ca2+ of excitable pituitary cells at resting potentials is controlled by steady state Ca2+ currents sensitive to dihydropyridines.

Early effects of PRL on ion conductances in CHO cells expressing PRL receptor.

Voltage-dependent ionic conductances in Chinese hamster ovary cells.

Voltage-dependent Ca2+ channels in Chinese hamster ovary (CHO) cells.

Prolactin receptor and signal transduction to milk protein genes.

Short term effect of prolactin on intracellular calcium in Chinese hamster ovary cells stably transfected with prolactin receptor complementary deoxyribonucleic acid.

Thyrotropin-releasing hormone and gonadotropin-releasing hormone-associated peptide modulation of [Ca2+]i in human lactotrophs.

Calcium signalling: comparison of the role of Ca2+ influx in excitable endocrine and non-excitable myeloid cells.

Complex effects of arachidonic acid and its lipoxygenase products on cytosolic calcium in GH3 cells.

Modulation of Ca2+ influx by protein phosphorylation in single intact clonal pituitary cells

Video imaging of cytosolic Ca2+ in pancreatic beta-cells stimulated by glucose, carbachol, and ATP.

Calcium-activated chloride conductance of lactotrophs: comparison of activation in normal and tumoral cells during thyrotropin-releasing-hormone stimulation.

Activation by bacterial lipopolysaccharide causes changes in the cytosolic free calcium concentration in single peritoneal macrophages.

Simultaneous monitoring of cytosolic free calcium and exocytosis at the single cell level.

The gonadotropin-releasing hormone associated peptide reduces calcium entry in prolactin-secreting cells.

[Long-term induced effects by only one treatment with ketoconazole on rat tumoral pituitary cells (GH3/B6 strains)]

Thyrotropin-releasing hormone activates a [Ca2+]i-dependent K+ current in GH3 pituitary cells via Ins(1,4,5)P3-sensitive and Ins(1,4,5)P3-insensitive mechanisms.

Differential effects of ketoconazole on prolactin and growth hormone release by normal and tumoral rat anterior pituitary cells in vitro.

Arachidonic acid affects membrane ionic conductances of GH3 pituitary cells.

Inhibitors of 1,2-diacylglycerol kinase potentiate the TRH-induced stimulation of Ca2+-activated K+ current.

GnRH-Associated Peptide Decreases Cyclic AMP Accumulation in the GH₃Pituitary Cell Line