April 2024
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity.
Authors : Cardouat G, Douard M, Bouchet C, Roubenne L, Kmecová Z, Esteves P, Brette F, Guignabert C, Tu L, Campagnac M, Robillard P, Coste F, Delcambre F, Thumerel M, Begueret H, Maurac A, Belaroussi Y, Klimas J, Ducret T, Quignard JF, Vacher P, Baudrimont I, Marthan R, Berger P, Guibert C, Freund-Michel V
July 2023
British Journal of Pharmacology
OP2113, a new drug for chronic hypoxia‐induced pulmonary hypertension treatment in rat
Authors : Lukas Roubenne, Margaux Laisné, David Benoist, Marilyne Campagnac, Bénédicte Prunet, Philippe Pasdois, Guillaume Cardouat, Thomas Ducret, Jean‐François Quignard, Pierre Vacher, Isabelle Baudrimont, Roger Marthan, Patrick Berger, Bruno Le Grand, Véronique Freund‐Michel, Christelle Guibert
June 2023
Cells
Pathophysiological Roles of the TRPV4 Channel in the Heart
Authors : Sébastien Chaigne, Solène Barbeau, Thomas Ducret, Romain Guinamard, David Benoist
April 2023
Pathophysiological Roles of TRPV4 Channel in the Heart
Authors : Sébastien Chaigne, Solène Barbeau, Thomas Ducret, Romain Guinamard, David Benoist
November 2022
Proceedings of the National Academy of Sciences
Genetically-encoded BRET probes shed light on ligand bias–induced variable ion selectivity in TRPV1 and P2X5/7
Authors : Yann Loïck Chappe, Sandra Pierredon, Alexandre Joushomme, Pablo Molle, André Garenne, Anne Canovi, Solène Barbeau, Florence Poulletier De Gannes, Annabelle Hurtier, Isabelle Lagroye, Thomas Ducret, Jean-François Quignard, Vincent Compan, Yann Percherancier
September 2022
Cells
Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism
Authors : Clément Bouchet, Guillaume Cardouat, Matthieu Douard, Florence Coste, Paul Robillard, Frédéric Delcambre, Thomas Ducret, Jean-François Quignard, Pierre Vacher, Isabelle Baudrimont, Roger Marthan, Patrick Berger, Christelle Guibert, Véronique Freund-Michel
July 2022
Cells
Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca2+ Influx and Akt-eNOS Pathway
Authors : Thais Porto Ribeiro, Solène Barbeau, Isabelle Baudrimont, Pierre Vacher, Véronique Freund-Michel, Guillaume Cardouat, Patrick Berger, Christelle Guibert, Thomas Ducret, Jean-François Quignard
July 2022
Biomolecules
Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia
Authors : Solène Barbeau, Alexandre Joushomme, Yann Chappe, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Patrick Berger, Pierre Vacher, Yann Percherancier, Jean-François Quignard, Thomas Ducret
April 2022
Antioxidants
NiONP-Induced Oxidative Stress and Mitochondrial Impairment in an In Vitro Pulmonary Vascular Cell Model Mimicking Endothelial Dysfunction
Authors : Ophélie Germande, Thomas Ducret, Jean-Francois Quignard, Juliette Deweirdt, Véronique Freund-Michel, Marie-Hélène Errera, Guillaume Cardouat, Pierre Vacher, Bernard Muller, Patrick Berger, Christelle Guibert, Magalie Baudrimont, Isabelle Baudrimont
February 2022
Revue des Maladies Respiratoires
Implication des canaux mécanosensibles Piezo1 et TRPV4 dans l’hypertension pulmonaire
Authors : S. Barbeau, T. Porto Ribeiro, G. Gilbert, G. Cardouat, I. Baudrimont, V. Freund-Michel, C. Guibert, R. Marthan, P. Vacher, J.-F. Quignard, T. Ducret
January 2022
Nanotoxicology
NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption.
Authors : Germande O, Baudrimont M, Beaufils F, Freund-Michel V, Ducret T, Quignard JF, Errera MH, Lacomme S, Gontier E, Mornet S, Bejko M, Muller B, Marthan R, Guibert C, Deweirdt J, Baudrimont I
September 2021
Biomolecules
Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension
Authors : Solène Barbeau, Guillaume Gilbert, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Pierre Vacher, Jean-François Quignard, Thomas Ducret
September 2021
Cardiovascular toxicology
Effects of FW2 Nanoparticles Toxicity in a New In Vitro Pulmonary Vascular Cells Model Mimicking Endothelial Dysfunction.
Authors : Deweirdt J, Ducret T, Quignard JF, Freund-Michel V, Lacomme S, Gontier E, Muller B, Marthan R, Guibert C, Baudrimont I
September 2021
Molecular Pharmacology
High-Throughput Screening of TRPV1 Ligands in the Light of the Bioluminescence Resonance Energy Transfer Technique
Authors : Yann Chappe, Pauline Michel, Alexandre Joushomme, Solène Barbeau, Sandra Pierredon, Luc Baron, André Garenne, Florence Poulletier De Gannes, Annabelle Hurtier, Stanislas Mayer, Isabelle Lagroye, Jean-François Quignard, Thomas Ducret, Vincent Compan, Christelle Franchet, Yann Percherancier
January 2021
American journal of physiology. Heart and circulatory physiology
Transient receptor potential vanilloid 4 channel participates in mouse ventricular electrical activity.
Authors :
February 2020
Cancer research
Correction: CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway in Triple-Negative Breast Cancer.
Authors : Malleter M, Tauzin S, Bessede A, Castellano R, Goubard A, Godey F, Levêque J, Jézéquel P, Campion L, Campone M, Ducret T, MacGrogan G, Debure L, Legembre P
January 2020
American Journal of Physiology-Lung Cellular and Molecular Physiology
TRPV4 channel mediates adventitial fibroblast activation and adventitial remodeling in pulmonary hypertension
Authors : Laure-Anne Cussac, Guillaume Cardouat, Nichiren Tiruchellvam Pillai, Marilyne Campagnac, Paul Robillard, Anaïs Montillaud, Christelle Guibert, Philippe Gailly, Roger Marthan, Jean-François Quignard, Jean-Pierre Savineau, Thomas Ducret
January 2020
Seminars in cancer biology
CD95/Fas and metastatic disease: What does not kill you makes you stronger
Authors : Guégan, Jean Philippe, Ginestier, Christophe, Charafe-Jauffret, Emmanuelle, Ducret, Thomas, Quignard, Jean-François, Vacher, Pierre, Legembre, Patrick
October 2019
PLoS biology
Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway.
Authors : Tauzin S, Chaigne-Delalande B, Selva E, Khadra N, Daburon S, Contin-Bordes C, Blanco P, Le Seyec J, Ducret T, Counillon L, Moreau JF, Hofman P, Legembre P
June 2019
American Journal of Respiratory Cell and Molecular Biology
Stretch-activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries
Authors : Audrey Lhomme, Guillaume Gilbert, Thomas Pele, Juliette Deweirdt, Daniel Henrion, Isabelle Baudrimont, Marilyne Campagnac, Roger Marthan, Christelle Guibert, Thomas Ducret, Jean-Pierre Savineau, Jean-François Quignard
November 2018
Nature chemical biology
Disrupting the CD95-PLCγ1 interaction prevents Th17-driven inflammation.
Authors : Poissonnier A, Guégan JP, Nguyen HT, Best D, Levoin N, Kozlov G, Gehring K, Pineau R, Jouan F, Morere L, Martin S, Thomas M, Lazaro E, Douchet I, Legembre P
November 2018
Cancers
The Role of the Anti-Aging Protein Klotho in IGF-1 Signaling and Reticular Calcium Leak: Impact on the Chemosensitivity of Dedifferentiated Liposarcomas.
Authors : Delcroix V, Mauduit O, Tessier N, Montillaud A, Lesluyes T, Ducret T, Chibon F, Van Coppenolle F, Ducreux S, Vacher P
January 2017
Oncotarget
The antidepressant fluoxetine induces necrosis by energy depletion and mitochondrial calcium overload.
Authors : Charles E, Hammadi M, Kischel P, Delcroix V, Demaurex N, Castelbou C, Vacher AM, Devin A, Ducret T, Nunes P, Vacher P
January 2017
Methods in molecular biology (Clifton, N.J.)
CD95-Mediated Calcium Signaling.
Authors : Hammadi M, Delcroix V, Vacher AM, Ducret T, Vacher P
January 2017
Biochemical pharmacology
T-type voltage gated calcium channels are involved in endothelium-dependent relaxation of mice pulmonary artery
Authors : Gilbert, Guillaume, Courtois, Arnaud, Dubois, Mathilde, Cussac, Laure-Anne, Ducret, Thomas, Lory, Philippe, Marthan, Roger, Savineau, Jean-Pierre, Quignard, Jean-François
January 2017
Journal of cellular physiology
HMGB1 down-regulation mediates terameprocol vascular anti-proliferative effect in experimental pulmonary hypertension
Authors : Nogueira-Ferreira, Rita, Ferreira-Pinto, Manuel J, Silva, Ana Filipa, Silva, Ana Filipa, Vitorino, Rui, Justino, Joana, Costa, Raquel, Moreira-Gonçalves, Daniel, Quignard, Jean-François, Ducret, Thomas, Savineau, Jean-Pierre, Leite-Moreira, Adelino F, Ferreira, Rita, Ferreira, Rita, Henriques-Coelho, Tiago
December 2016
Toxicology
Calcium signalling induced by in vitro exposure to silicium dioxide nanoparticles in rat pulmonary artery smooth muscle cells.
Authors : Dubes V, Parpaite T, Ducret T, Quignard JF, Mornet S, Reinhardt N, Baudrimont I, Dubois M, Freund-Michel V, Marthan R, Muller B, Savineau JP, Courtois A
July 2016
Immunity
CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice.
Authors : Poissonnier A, Sanséau D, Le Gallo M, Malleter M, Levoin N, Viel R, Morere L, Penna A, Blanco P, Dupuy A, Poizeau F, Fautrel A, Seneschal J, Jouan F, Legembre P
July 2016
Cell death and differentiation
The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca(2+) flux from the endoplasmic reticulum to mitochondria.
Authors : Fouqué A, Lepvrier E, Debure L, Gouriou Y, Malleter M, Delcroix V, Ovize M, Ducret T, Li C, Hammadi M, Vacher P, Legembre P
March 2016
American journal of physiology. Lung cellular and molecular physiology
Caveolae are involved in mechanotransduction during pulmonary hypertension.
Authors : Gilbert G, Ducret T, Savineau JP, Marthan R, Quignard JF
July 2015
Journal of immunology (Baltimore, Md. : 1950)
Localized Store-Operated Calcium Influx Represses CD95-Dependent Apoptotic Effects of Rituximab in Non-Hodgkin B Lymphomas.
Authors : Vacher P, Vacher AM, Pineau R, Latour S, Soubeyran I, Pangault C, Tarte K, Soubeyran P, Ducret T, Bresson-Bepoldin L
March 2015
Pflugers Archiv : European journal of physiology
Effect of hypoxia on TRPV1 and TRPV4 channels in rat pulmonary arterial smooth muscle cells.
Authors : Parpaite T, Cardouat G, Mauroux M, Gillibert-Duplantier J, Robillard P, Quignard JF, Marthan R, Savineau JP, Ducret T
April 2014
Cardiovascular research
Stretch-induced Ca2+ signalling in vascular smooth muscle cells depends on Ca2+ store segregation.
Authors : Gilbert G, Ducret T, Marthan R, Savineau JP, Quignard JF
September 2013
Cancer research
CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer.
Authors : Malleter M, Tauzin S, Bessede A, Castellano R, Goubard A, Godey F, Levêque J, Jézéquel P, Campion L, Campone M, Ducret T, MacGrogan G, Debure L, Legembre P
May 2013
Pediatric research
Beneficial effect of dehydroepiandrosterone on pulmonary hypertension in a rodent model of pulmonary hypertension in infants.
Authors : Dumas de la Roque E, Quignard JF, Ducret T, Dahan D, Courtois A, Begueret H, Marthan R, Savineau JP
September 2012
American journal of physiology. Lung cellular and molecular physiology
Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.
Authors : Dahan D, Ducret T, Quignard JF, Marthan R, Savineau JP, Estève E
July 2012
Pflugers Archiv : European journal of physiology
Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells.
Authors : Martin E, Dahan D, Cardouat G, Gillibert-Duplantier J, Marthan R, Savineau JP, Ducret T
April 2012
The European respiratory journal
Dehydroepiandrosterone reverses chronic hypoxia/reoxygenation-induced right ventricular dysfunction in rats.
Authors : Dumas de La Roque E, Bellance N, Rossignol R, Begueret H, Billaud M, dos Santos P, Ducret T, Marthan R, Dahan D, Ramos-Barbón D, Amor-Carro Ó, Fayon M
November 2011
Proceedings of the National Academy of Sciences of the United States of America
CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.
Authors : Khadra N, Bresson-Bepoldin L, Penna A, Chaigne-Delalande B, Ségui B, Levade T, Vacher AM, Reiffers J, Ducret T, Moreau JF, Cahalan MD, Vacher P, Legembre P
June 2011
PLoS biology
The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.
Authors : Tauzin S, Chaigne-Delalande B, Selva E, Khadra N, Daburon S, Contin-Bordes C, Blanco P, Le Seyec J, Ducret T, Counillon L, Moreau JF, Hofman P, Legembre P
January 2011
Transient Receptor Potential Channels
Expression and Physiological Roles of TRP Channels in Smooth Muscle Cells
Authors : Guibert, Christelle, Ducret, Thomas, Savineau, Jean-Pierre
January 2011
Nmr in Biomedicine
Effect of chronic hypoxia on pulmonary artery blood velocity in rats as assessed by electrocardiography-triggered three-dimensional time-resolved MR angiography
Authors : de La Roque, Eric Dumas, Thiaudiere, Eric, Ducret, Thomas, Marthan, Roger, Franconi, Jean-Michel, Guibert, Christelle, Parzy, Elodie
October 2010
Cell calcium
Stretch-activated channels in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.
Authors : Ducret T, El Arrouchi J, Courtois A, Quignard JF, Marthan R, Savineau JP
January 2010
Toxicology and Applied Pharmacology
Effect of engineered nanoparticles on vasomotor responses in rat intrapulmonary artery
Authors : Courtois, Arnaud, Andujar, Pascal, Ladeiro, Yannick, Ducret, Thomas, Rogerieux, Francoise, Lacroix, Ghislaine, Baudrimont, Isabelle, Guibert, Christelle, Roux, Etienne, Canal-Raffin, Mireille, Brochard, Patrick, Marano, Francelyne, Marthan, Roger, Muller, Bernard
January 2009
European Respiratory Journal
Signalling pathways involved in the contractile response to 5-HT in the human pulmonary artery
Authors : Rodat-Despoix, L., Aires, V., Ducret, T., Marthan, R., Savineau, J. P., Rousseau, E., Guibert, C.
January 2008
Progress in Biophysics & Molecular Biology
Voltage-independent calcium influx in smooth muscle
Authors : Guibert, Christelle, Ducret, Thomas, Savineau, Jean-Pierre
January 2008
Cell Calcium
Serotonin-induced activation of TRPV4-like current in rat intrapulmonary arterial smooth muscle cells
Authors : Ducret, Thomas, Guibert, Christelle, Marthan, Roger, Savineau, Jean-Pierre
July 2006
The Journal of physiology
Functional role of store-operated and stretch-activated channels in murine adult skeletal muscle fibres.
Authors : Ducret T, Vandebrouck C, Cao ML, Lebacq J, Gailly P
March 2006
Cell calcium
Calcium store contents control the expression of TRPC1, TRPC3 and TRPV6 proteins in LNCaP prostate cancer cell line.
Authors : Pigozzi D, Ducret T, Tajeddine N, Gala JL, Tombal B, Gailly P
October 2005
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Regulation of store-operated calcium entries and mitochondrial uptake by minidystrophin expression in cultured myotubes.
Authors : Vandebrouck A, Ducret T, Basset O, Sebille S, Raymond G, Ruegg U, Gailly P, Cognard C, Constantin B
March 2005
Molecular biology of the cell
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel.
Authors : Dejean LM, Martinez-Caballero S, Guo L, Hughes C, Teijido O, Ducret T, Ichas F, Korsmeyer SJ, Antonsson B, Jonas EA, Kinnally KW
November 2004
Cell calcium
Role of store-dependent influx of Ca2+ and efflux of K+ in apoptosis of CHO cells.
Authors : Pigozzi D, Tombal B, Ducret T, Vacher P, Gailly P
October 2003
Journal of neurophysiology
Effects of prolactin on ionic membrane conductances in the human malignant astrocytoma cell line U87-MG.
Authors : Ducret T, Vacher AM, Vacher P
October 2003
Molecular membrane biology
Voltage-dependent ionic conductances in the human malignant astrocytoma cell line U87-MG.
Authors : Ducret T, Vacher AM, Vacher P
May 2002
Glia
Effects of prolactin on intracellular calcium concentration and cell proliferation in human glioma cells.
Authors : Ducret T, Boudina S, Sorin B, Vacher AM, Gourdou I, Liguoro D, Guerin J, Bresson-Bepoldin L, Vacher P