Members

Thomas TRIAN

University Professor

Email : [email protected]
ORCID : 0000-0002-2567-4867

Professional background

– 2022: Full Professor of Biochemistry, Faculty of Pharmacy
– 2018: Awarded the HDR (Habilitation to Supervise Research)
– 2012: Lecturer, Faculty of Pharmacy
– 2011: Postdoctoral Fellowship, Bordeaux Cardio-Thoracic Research Center
– 2007-2010: Postdoctoral Fellowship, Woolcock Institute of Medical Research, Sydney, Australia
– 2004-2007: PhD in Biology and Health Sciences, University of Bordeaux. Role of bronchial smooth muscle cells in the pathophysiology of asthma.

Funding

Grants as Principal investigator

• 2025-2020: ANR PRC (Co-PI avec Fabien Beaufils). Project ICEBERG. Identification of prediCtive biomarkers and pathophysiological mEchanisms of BR1 and BR2, the two nEw bronchial RemodelinG-based endotypes of severe preschool wheezers. 450 k€
• 2024-2025: Fondation Bordeaux Université : Role of bronchial epithelial energy metabolism in pediatric asthma. 20 k€
• 2022-2025 : ANR PRC (Other associated investigators: ML. Andreola (Bordeaux), Harald Wooldrish (Bordeaux), Marc Landry (Bordeaux) et Laure Emmanuelle ZARAGOSI (Nice)). Projet VIRCHILLED. Comparison of SARS-CoV-2, AdenoVIRus and Rhinovirus infection of the respiratory epithelium in CHILdren vs. the eLDerly. 800 k€
• 2021-2023 : Aquitaine Science Transfert (Patrick Berger, Pauline Esteves et Thomas Trian). New biotherapy for the treatment of severe asthma: development of a drug candidate molecule (humanized antibody fragment), an inhibitor of the fatty acid receptor (LDL-R) of bronchial smooth muscle cells in severe asthma. 400 k€
• 2019-2020 : ANR Flash COVID (ML. Andreola, CNRS UMR5234, Harald Wooldrish CNRS UMR5234, Denis Malvy, CHU de Bordeaux et Thomas Trian): Projet “ANACONDA” Analysis of Covid-19 infection and its inflammatory response in a differentiated human bronchial epithelium model. 192 k€
• 2018-2021: ANR JCJC (Thomas Trian): Role of bronchial Smooth muscle on Asthma Exacerbations (ROSAE). 297 k€

Grants as associated investigator

• 2024-2028: ANR PRCI (France/Germany): PI Markus Weckmann (Université de Lübeck). Projet ARMADA ; childhood Asthma: micRobioMe And Dna-methylations in trAined immunity to reset asthma. 600 k€.
• 2024-2028: Programmes Scientifiques de Grande Ambition Régionale (PSGAR) : PI : L.DELHAES, D.MALVY. Projet : Microbial Exposome and Health Risk: The Importance of One Health Management of Issues Related to Zoonotic Influenza EMERG (1,9M€).
• 2021-2024 : AstraZeneca (Södertälje, Suède). (P.Berger) : . Cell interactions between bronchial epithelial cells and structural cells in both asthma and COPD. 150 k€/an pendant 3 ans.
• 2019-2022 : AstraZeneca (Södertälje, Suède). (PO. Girodet) “BENRAMOD” Project : Effect of Benralizumab on bronchial smooth muscle remodeling in asthma. 159 k€
• 2017-2020 : Fondation pour la Recherche Médicale Equipe FRM (P. Berger) : Role of bronchial smooth muscle in asthma exacerbations: pathophysiology of mitochondrial dysfunction and therapeutic implications. 371 k€

Publications 31

March 2025

Improving efficiency of homology-directed repair with ZIP CRISPR

Authors : C Thibault, J Rosier, R Espasa, V Marin, M Riandière, C Berges, S Fayet, I Lamrissi-Garcia, M Lalanne, T Trian, S Bui, S Dabernat, J Boutin, F Moreau-Gaudry, A Bedel
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May 2021

SARS-CoV-2 transmission via apical syncytia release from primary bronchial epithelia and infectivity restriction in children epithelia

Authors : Beucher G, Blondot M, Celle A, Pied N, Recordon-Pinson P, Esteves P, Faure M, Métifiot M, Lacomme S, Dacheaux D, Robinson D, Längst G, Beaufils F, Wodrich H
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April 2021 The European respiratory journal

Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling.

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April 2021 The Journal of allergy and clinical immunology

Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers.

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September 2020 European respiratory review : an official journal of the European Respiratory Society

Mitochondrial dysfunction in lung ageing and disease.

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March 2020 Revue des Maladies Respiratoires

La mitochondrie du muscle lisse bronchique : une nouvelle cible thérapeutique dans l’asthme?

Authors : P. Esteves, A. Celle, P. Berger, T. Trian
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September 2019 The European respiratory journal

Fibrocyte accumulation in the airway walls of COPD patients.

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January 2019 Frontiers in immunology

Asthmatic Bronchial Smooth Muscle Increases CCL5-Dependent Monocyte Migration in Response to Rhinovirus-Infected Epithelium.

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October 2018

Fibrocyte accumulation in bronchi: a cellular hallmark of COPD

Authors : Isabelle Dupin, Matthieu Thumerel, Elise Maurat, Florence Coste, Hugues Begueret, Thomas Trian, Michel Montaudon, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger
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March 2016 American journal of respiratory and critical care medicine

Bronchial Smooth Muscle Remodeling in Nonsevere Asthma.

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January 2016 Journal of Allergy and Clinical Immunology

Blood fibrocytes are recruited during acute exacerbations of chronic obstructive pulmonary disease through a CXCR4-dependent pathway

Authors : Dupin, I., Allard, B., Ozier, A., Maurat, E., Ousova, O., Delbrel, E., Trian, T., Bui, H.-N., Dromer, C., Guisset, O., Blanchard, E., Hilbert, G., Vargas, F., Thumerel, M., Marthan, R., Girodet, P.-O., Berger, P.
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January 2016 Journal of Allergy and Clinical Immunology

Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients

Authors : Trian, T., Allard, B., Ozier, A., Maurat, E., Dupin, I., Thumerel, M., Ousova, O., Gillibert-Duplantier, J., Le Morvan, V., Begueret, H., Girodet, P.-O., Marthan, R., Berger, P.
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June 2015 Thorax

Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma.

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April 2015 American Journal of Respiratory and Critical Care Medicine

Calcium channel blocker reduces airway remodeling in severe asthma. A proof-of-concept study.

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March 2015 American journal of respiratory and critical care medicine

House dust mites induce proliferation of severe asthmatic smooth muscle cells via an epithelium-dependent pathway.

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February 2015 Journal of cell science

Human FAM154A (SAXO1) is a microtubule-stabilizing protein specific to cilia and related structures.

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January 2015 American journal of respiratory and critical care medicine

What about targeting smooth muscle remodeling in severe asthma?

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February 2014 PloS one

Protease activated receptor-2 expression and function in asthmatic bronchial smooth muscle.

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August 2013 Antioxidants & Redox Signaling

Adaptative Capacity of Mitochondrial Biogenesis and of Mitochondrial Dynamics in Response to Pathogenic Respiratory Chain Dysfunction

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August 2012 Pulmonary pharmacology & therapeutics

Phenotype modulation of airway smooth muscle in asthma.

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August 2012 Pulmonary pharmacology & therapeutics

Functional phenotype of airway myocytes from asthmatic airways.

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August 2012 Journal of Cellular Physiology

The phosphoinositide 3′-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle

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November 2011 American journal of physiology. Lung cellular and molecular physiology

β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers.

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May 2011 PLoS ONE

β2-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D

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May 2011 Journal of Pharmacology and Experimental Therapeutics

Phosphatidylinositol 3-Kinase Isoform-Specific Effects in Airway Mesenchymal Cell Function

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January 2011 Journal of Allergy

The Pivotal Role of Airway Smooth Muscle in Asthma Pathophysiology

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August 2010 American Journal of Respiratory Cell and Molecular Biology

Rhinovirus-Induced Exacerbations of Asthma

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February 2010 Allergy

Mast cell adhesion to bronchial smooth muscle in asthma specifically depends on CD51 and CD44 variant 6.

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March 2009 Journal of Asthma and Allergy

Reconstruction is not renovation – the role of remodeling in asthma

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December 2007 The Journal of experimental medicine

Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma.

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September 2005 American journal of respiratory cell and molecular biology

RNA interference decreases PAR-2 expression and function in human airway smooth muscle cells.

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Team

Team 2

Bronchial remodeling

The study of the mechanisms and treatments of bronchial remodeling in asthma and chronic bronchitis is at the heart of this team's work. It has recognized expertise in epithelium-muscle interactions, functional imaging and clinical research.

Leadership : Patrick BERGER