The general objective of the “Cardiac Electrophysiology” team is to better understand the electrical dysfunctions of the heart, which are responsible for numerous cardiovascular diseases and sudden deaths, and thus directly or indirectly account for nearly one-third of deaths worldwide.
Our team is fully integrated within the LIRYC Institute (Electrophysiology and Heart Modeling Institute), one of the 19 University Hospital Institutes (IHUs) created nationwide to boost biomedical research and innovation. The Institute provides a platform that combines state-of-the-art equipment and expertise in interventional cardiology, imaging, modeling, and signal processing.
The specific objectives of the team are to:
- Conduct clinical and translational investigations — from cell to patient — to elucidate the mechanisms of cardiac arrhythmias and better understand electromechanical dysfunctions of the heart.
- Create synergy among multidisciplinary researchers to develop high-resolution (millisecond and micrometer scale) 3D and panoramic mapping and imaging methods to improve prevention and diagnosis.
- Develop new therapeutic approaches through a biomedical innovation platform that enables the transfer of biotechnological or pharmacological tools to the scientific and industrial communities.
The team addresses the most common arrhythmia (atrial fibrillation), which is also a major risk factor for embolic strokes, and the most fatal disorders of cardiac rhythm (ventricular fibrillation), as well as ventricular dyssynchrony leading to heart failure.