Thomas DUCRET

Professeur des Universités

Email : [email protected]

ORCID : 0000-0002-5146-6869

Parcours professionnel

Professeur des Universités de première classe (PR 1C) en Physiologie animale (CNU section 66, UF de Biologie, Université de Bordeaux)

Publications 55

avril 2024 Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity.

Auteurs : Cardouat G, Douard M, Bouchet C, Roubenne L, Kmecová Z, Esteves P, Brette F, Guignabert C, Tu L, Campagnac M, Robillard P, Coste F, Delcambre F, Thumerel M, Begueret H, Maurac A, Belaroussi Y, Klimas J, Ducret T, Quignard JF, Vacher P, Baudrimont I, Marthan R, Berger P, Guibert C, Freund-Michel V

juillet 2023 British Journal of Pharmacology

OP2113, a new drug for chronic hypoxia‐induced pulmonary hypertension treatment in rat

Auteurs : Lukas Roubenne, Margaux Laisné, David Benoist, Marilyne Campagnac, Bénédicte Prunet, Philippe Pasdois, Guillaume Cardouat, Thomas Ducret, Jean‐François Quignard, Pierre Vacher, Isabelle Baudrimont, Roger Marthan, Patrick Berger, Bruno Le Grand, Véronique Freund‐Michel, Christelle Guibert

juin 2023 Cells

Pathophysiological Roles of the TRPV4 Channel in the Heart

Auteurs : Sébastien Chaigne, Solène Barbeau, Thomas Ducret, Romain Guinamard, David Benoist

Pathophysiological Roles of TRPV4 Channel in the Heart

Auteurs : Sébastien Chaigne, Solène Barbeau, Thomas Ducret, Romain Guinamard, David Benoist

novembre 2022 Proceedings of the National Academy of Sciences

Genetically-encoded BRET probes shed light on ligand bias–induced variable ion selectivity in TRPV1 and P2X5/7

Auteurs : Yann Loïck Chappe, Sandra Pierredon, Alexandre Joushomme, Pablo Molle, André Garenne, Anne Canovi, Solène Barbeau, Florence Poulletier De Gannes, Annabelle Hurtier, Isabelle Lagroye, Thomas Ducret, Jean-François Quignard, Vincent Compan, Yann Percherancier

septembre 2022 Cells

Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism

Auteurs : Clément Bouchet, Guillaume Cardouat, Matthieu Douard, Florence Coste, Paul Robillard, Frédéric Delcambre, Thomas Ducret, Jean-François Quignard, Pierre Vacher, Isabelle Baudrimont, Roger Marthan, Patrick Berger, Christelle Guibert, Véronique Freund-Michel

juillet 2022 Cells

Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca2+ Influx and Akt-eNOS Pathway

Auteurs : Thais Porto Ribeiro, Solène Barbeau, Isabelle Baudrimont, Pierre Vacher, Véronique Freund-Michel, Guillaume Cardouat, Patrick Berger, Christelle Guibert, Thomas Ducret, Jean-François Quignard

juillet 2022 Biomolecules

Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia

Auteurs : Solène Barbeau, Alexandre Joushomme, Yann Chappe, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Patrick Berger, Pierre Vacher, Yann Percherancier, Jean-François Quignard, Thomas Ducret

avril 2022 Antioxidants

NiONP-Induced Oxidative Stress and Mitochondrial Impairment in an In Vitro Pulmonary Vascular Cell Model Mimicking Endothelial Dysfunction

Auteurs : Ophélie Germande, Thomas Ducret, Jean-Francois Quignard, Juliette Deweirdt, Véronique Freund-Michel, Marie-Hélène Errera, Guillaume Cardouat, Pierre Vacher, Bernard Muller, Patrick Berger, Christelle Guibert, Magalie Baudrimont, Isabelle Baudrimont

février 2022 Revue des Maladies Respiratoires

Implication des canaux mécanosensibles Piezo1 et TRPV4 dans l’hypertension pulmonaire

Auteurs : S. Barbeau, T. Porto Ribeiro, G. Gilbert, G. Cardouat, I. Baudrimont, V. Freund-Michel, C. Guibert, R. Marthan, P. Vacher, J.-F. Quignard, T. Ducret

janvier 2022 Nanotoxicology

NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption.

Auteurs : Germande O, Baudrimont M, Beaufils F, Freund-Michel V, Ducret T, Quignard JF, Errera MH, Lacomme S, Gontier E, Mornet S, Bejko M, Muller B, Marthan R, Guibert C, Deweirdt J, Baudrimont I

septembre 2021 Biomolecules

Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension

Auteurs : Solène Barbeau, Guillaume Gilbert, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Pierre Vacher, Jean-François Quignard, Thomas Ducret

septembre 2021 Cardiovascular toxicology

Effects of FW2 Nanoparticles Toxicity in a New In Vitro Pulmonary Vascular Cells Model Mimicking Endothelial Dysfunction.

Auteurs : Deweirdt J, Ducret T, Quignard JF, Freund-Michel V, Lacomme S, Gontier E, Muller B, Marthan R, Guibert C, Baudrimont I

septembre 2021 Molecular Pharmacology

High-Throughput Screening of TRPV1 Ligands in the Light of the Bioluminescence Resonance Energy Transfer Technique

Auteurs : Yann Chappe, Pauline Michel, Alexandre Joushomme, Solène Barbeau, Sandra Pierredon, Luc Baron, André Garenne, Florence Poulletier De Gannes, Annabelle Hurtier, Stanislas Mayer, Isabelle Lagroye, Jean-François Quignard, Thomas Ducret, Vincent Compan, Christelle Franchet, Yann Percherancier

janvier 2021 American journal of physiology. Heart and circulatory physiology

Transient receptor potential vanilloid 4 channel participates in mouse ventricular electrical activity.

février 2020 Cancer research

Correction: CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway in Triple-Negative Breast Cancer.

Auteurs : Malleter M, Tauzin S, Bessede A, Castellano R, Goubard A, Godey F, Levêque J, Jézéquel P, Campion L, Campone M, Ducret T, MacGrogan G, Debure L, Legembre P

janvier 2020 American Journal of Physiology-Lung Cellular and Molecular Physiology

TRPV4 channel mediates adventitial fibroblast activation and adventitial remodeling in pulmonary hypertension

Auteurs : Laure-Anne Cussac, Guillaume Cardouat, Nichiren Tiruchellvam Pillai, Marilyne Campagnac, Paul Robillard, Anaïs Montillaud, Christelle Guibert, Philippe Gailly, Roger Marthan, Jean-François Quignard, Jean-Pierre Savineau, Thomas Ducret

janvier 2020 Seminars in cancer biology

CD95/Fas and metastatic disease: What does not kill you makes you stronger

Auteurs : Guégan, Jean Philippe, Ginestier, Christophe, Charafe-Jauffret, Emmanuelle, Ducret, Thomas, Quignard, Jean-François, Vacher, Pierre, Legembre, Patrick

octobre 2019 PLoS biology

Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway.

Auteurs : Tauzin S, Chaigne-Delalande B, Selva E, Khadra N, Daburon S, Contin-Bordes C, Blanco P, Le Seyec J, Ducret T, Counillon L, Moreau JF, Hofman P, Legembre P

juin 2019 American Journal of Respiratory Cell and Molecular Biology

Stretch-activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries

Auteurs : Audrey Lhomme, Guillaume Gilbert, Thomas Pele, Juliette Deweirdt, Daniel Henrion, Isabelle Baudrimont, Marilyne Campagnac, Roger Marthan, Christelle Guibert, Thomas Ducret, Jean-Pierre Savineau, Jean-François Quignard

novembre 2018 Nature chemical biology

Disrupting the CD95-PLCγ1 interaction prevents Th17-driven inflammation.

Auteurs : Poissonnier A, Guégan JP, Nguyen HT, Best D, Levoin N, Kozlov G, Gehring K, Pineau R, Jouan F, Morere L, Martin S, Thomas M, Lazaro E, Douchet I, Legembre P

novembre 2018 Cancers

The Role of the Anti-Aging Protein Klotho in IGF-1 Signaling and Reticular Calcium Leak: Impact on the Chemosensitivity of Dedifferentiated Liposarcomas.

Auteurs : Delcroix V, Mauduit O, Tessier N, Montillaud A, Lesluyes T, Ducret T, Chibon F, Van Coppenolle F, Ducreux S, Vacher P

janvier 2017 Oncotarget

The antidepressant fluoxetine induces necrosis by energy depletion and mitochondrial calcium overload.

Auteurs : Charles E, Hammadi M, Kischel P, Delcroix V, Demaurex N, Castelbou C, Vacher AM, Devin A, Ducret T, Nunes P, Vacher P

janvier 2017 Methods in molecular biology (Clifton, N.J.)

CD95-Mediated Calcium Signaling.

Auteurs : Hammadi M, Delcroix V, Vacher AM, Ducret T, Vacher P

janvier 2017 Biochemical pharmacology

T-type voltage gated calcium channels are involved in endothelium-dependent relaxation of mice pulmonary artery

Auteurs : Gilbert, Guillaume, Courtois, Arnaud, Dubois, Mathilde, Cussac, Laure-Anne, Ducret, Thomas, Lory, Philippe, Marthan, Roger, Savineau, Jean-Pierre, Quignard, Jean-François

janvier 2017 Journal of cellular physiology

HMGB1 down-regulation mediates terameprocol vascular anti-proliferative effect in experimental pulmonary hypertension

Auteurs : Nogueira-Ferreira, Rita, Ferreira-Pinto, Manuel J, Silva, Ana Filipa, Silva, Ana Filipa, Vitorino, Rui, Justino, Joana, Costa, Raquel, Moreira-Gonçalves, Daniel, Quignard, Jean-François, Ducret, Thomas, Savineau, Jean-Pierre, Leite-Moreira, Adelino F, Ferreira, Rita, Ferreira, Rita, Henriques-Coelho, Tiago

décembre 2016 Toxicology

Calcium signalling induced by in vitro exposure to silicium dioxide nanoparticles in rat pulmonary artery smooth muscle cells.

Auteurs : Dubes V, Parpaite T, Ducret T, Quignard JF, Mornet S, Reinhardt N, Baudrimont I, Dubois M, Freund-Michel V, Marthan R, Muller B, Savineau JP, Courtois A

juillet 2016 Immunity

CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice.

Auteurs : Poissonnier A, Sanséau D, Le Gallo M, Malleter M, Levoin N, Viel R, Morere L, Penna A, Blanco P, Dupuy A, Poizeau F, Fautrel A, Seneschal J, Jouan F, Legembre P

juillet 2016 Cell death and differentiation

The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca(2+) flux from the endoplasmic reticulum to mitochondria.

Auteurs : Fouqué A, Lepvrier E, Debure L, Gouriou Y, Malleter M, Delcroix V, Ovize M, Ducret T, Li C, Hammadi M, Vacher P, Legembre P

mars 2016 American journal of physiology. Lung cellular and molecular physiology

Caveolae are involved in mechanotransduction during pulmonary hypertension.

Auteurs : Gilbert G, Ducret T, Savineau JP, Marthan R, Quignard JF

juillet 2015 Journal of immunology (Baltimore, Md. : 1950)

Localized Store-Operated Calcium Influx Represses CD95-Dependent Apoptotic Effects of Rituximab in Non-Hodgkin B Lymphomas.

Auteurs : Vacher P, Vacher AM, Pineau R, Latour S, Soubeyran I, Pangault C, Tarte K, Soubeyran P, Ducret T, Bresson-Bepoldin L

mars 2015 Pflugers Archiv : European journal of physiology

Effect of hypoxia on TRPV1 and TRPV4 channels in rat pulmonary arterial smooth muscle cells.

Auteurs : Parpaite T, Cardouat G, Mauroux M, Gillibert-Duplantier J, Robillard P, Quignard JF, Marthan R, Savineau JP, Ducret T

avril 2014 Cardiovascular research

Stretch-induced Ca2+ signalling in vascular smooth muscle cells depends on Ca2+ store segregation.

Auteurs : Gilbert G, Ducret T, Marthan R, Savineau JP, Quignard JF

septembre 2013 Cancer research

CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer.

Auteurs : Malleter M, Tauzin S, Bessede A, Castellano R, Goubard A, Godey F, Levêque J, Jézéquel P, Campion L, Campone M, Ducret T, MacGrogan G, Debure L, Legembre P

mai 2013 Pediatric research

Beneficial effect of dehydroepiandrosterone on pulmonary hypertension in a rodent model of pulmonary hypertension in infants.

Auteurs : Dumas de la Roque E, Quignard JF, Ducret T, Dahan D, Courtois A, Begueret H, Marthan R, Savineau JP

septembre 2012 American journal of physiology. Lung cellular and molecular physiology

Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.

Auteurs : Dahan D, Ducret T, Quignard JF, Marthan R, Savineau JP, Estève E

juillet 2012 Pflugers Archiv : European journal of physiology

Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells.

Auteurs : Martin E, Dahan D, Cardouat G, Gillibert-Duplantier J, Marthan R, Savineau JP, Ducret T

avril 2012 The European respiratory journal

Dehydroepiandrosterone reverses chronic hypoxia/reoxygenation-induced right ventricular dysfunction in rats.

Auteurs : Dumas de La Roque E, Bellance N, Rossignol R, Begueret H, Billaud M, dos Santos P, Ducret T, Marthan R, Dahan D, Ramos-Barbón D, Amor-Carro Ó, Fayon M

novembre 2011 Proceedings of the National Academy of Sciences of the United States of America

CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.

Auteurs : Khadra N, Bresson-Bepoldin L, Penna A, Chaigne-Delalande B, Ségui B, Levade T, Vacher AM, Reiffers J, Ducret T, Moreau JF, Cahalan MD, Vacher P, Legembre P

juin 2011 PLoS biology

The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.

Auteurs : Tauzin S, Chaigne-Delalande B, Selva E, Khadra N, Daburon S, Contin-Bordes C, Blanco P, Le Seyec J, Ducret T, Counillon L, Moreau JF, Hofman P, Legembre P

janvier 2011 Transient Receptor Potential Channels

Expression and Physiological Roles of TRP Channels in Smooth Muscle Cells

Auteurs : Guibert, Christelle, Ducret, Thomas, Savineau, Jean-Pierre

janvier 2011 Nmr in Biomedicine

Effect of chronic hypoxia on pulmonary artery blood velocity in rats as assessed by electrocardiography-triggered three-dimensional time-resolved MR angiography

Auteurs : de La Roque, Eric Dumas, Thiaudiere, Eric, Ducret, Thomas, Marthan, Roger, Franconi, Jean-Michel, Guibert, Christelle, Parzy, Elodie

octobre 2010 Cell calcium

Stretch-activated channels in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.

Auteurs : Ducret T, El Arrouchi J, Courtois A, Quignard JF, Marthan R, Savineau JP

janvier 2010 Toxicology and Applied Pharmacology

Effect of engineered nanoparticles on vasomotor responses in rat intrapulmonary artery

Auteurs : Courtois, Arnaud, Andujar, Pascal, Ladeiro, Yannick, Ducret, Thomas, Rogerieux, Francoise, Lacroix, Ghislaine, Baudrimont, Isabelle, Guibert, Christelle, Roux, Etienne, Canal-Raffin, Mireille, Brochard, Patrick, Marano, Francelyne, Marthan, Roger, Muller, Bernard

janvier 2009 European Respiratory Journal

Signalling pathways involved in the contractile response to 5-HT in the human pulmonary artery

Auteurs : Rodat-Despoix, L., Aires, V., Ducret, T., Marthan, R., Savineau, J. P., Rousseau, E., Guibert, C.

janvier 2008 Progress in Biophysics & Molecular Biology

Voltage-independent calcium influx in smooth muscle

Auteurs : Guibert, Christelle, Ducret, Thomas, Savineau, Jean-Pierre

janvier 2008 Cell Calcium

Serotonin-induced activation of TRPV4-like current in rat intrapulmonary arterial smooth muscle cells

Auteurs : Ducret, Thomas, Guibert, Christelle, Marthan, Roger, Savineau, Jean-Pierre

juillet 2006 The Journal of physiology

Functional role of store-operated and stretch-activated channels in murine adult skeletal muscle fibres.

Auteurs : Ducret T, Vandebrouck C, Cao ML, Lebacq J, Gailly P

mars 2006 Cell calcium

Calcium store contents control the expression of TRPC1, TRPC3 and TRPV6 proteins in LNCaP prostate cancer cell line.

Auteurs : Pigozzi D, Ducret T, Tajeddine N, Gala JL, Tombal B, Gailly P

octobre 2005 FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Regulation of store-operated calcium entries and mitochondrial uptake by minidystrophin expression in cultured myotubes.

Auteurs : Vandebrouck A, Ducret T, Basset O, Sebille S, Raymond G, Ruegg U, Gailly P, Cognard C, Constantin B

mars 2005 Molecular biology of the cell

Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel.

Auteurs : Dejean LM, Martinez-Caballero S, Guo L, Hughes C, Teijido O, Ducret T, Ichas F, Korsmeyer SJ, Antonsson B, Jonas EA, Kinnally KW

novembre 2004 Cell calcium

Role of store-dependent influx of Ca2+ and efflux of K+ in apoptosis of CHO cells.

Auteurs : Pigozzi D, Tombal B, Ducret T, Vacher P, Gailly P

octobre 2003 Journal of neurophysiology

Effects of prolactin on ionic membrane conductances in the human malignant astrocytoma cell line U87-MG.

Auteurs : Ducret T, Vacher AM, Vacher P

octobre 2003 Molecular membrane biology

Voltage-dependent ionic conductances in the human malignant astrocytoma cell line U87-MG.

Auteurs : Ducret T, Vacher AM, Vacher P

Effects of prolactin on intracellular calcium concentration and cell proliferation in human glioma cells.

Auteurs : Ducret T, Boudina S, Sorin B, Vacher AM, Gourdou I, Liguoro D, Guerin J, Bresson-Bepoldin L, Vacher P