Jean-François QUIGNARD

Professeur d’Université

Parcours professionnel

Parcours professionnel :

Etude de pharmacie (Docteur en Pharmacie, Univ Montpellier 2005).
DEA Biologie-Santé (Univ. Montpellier I, 1993)
Service militaire centre de recherche des armées (CRSSA, La Tronche, France, 1996)
Doctorat universitaire (Pr. J. Nargeot, Univ Montpellier I, 1997).
Post Doctorat à l’institut de recherche Servier (IdRS, Suresnes, 1997)
Maître de conférence en physiologie (UFR Sciences Pharmaceutiques, Univ Bordeaux, 1998, CNRS-UMR 5017, Signalisation et interaction cellulaire )
Habilitation à Diriger les Recherches (Univ. Bordeaux, 2007)
Professeur de physiologie (UFR Sciences Pharmaceutiques, Univ Bordeaux, 2008, Centre de Recherche Cardio-Thoracique de Bordeaux INSERM U1045)

Fonctions :

Responsable de l’équipe pédagogique de physiologie pharmacie.
Responsable de la 2ème année de pharmacie et des stages d’initiation officinaux
Membre du conseil de l’UFR Sciences Pharmaceutiques
Membre du CNU-86 sciences du médicament et autres produits de santé
Coresponsable du projet AMI-CMA CAP BIOSPACE

Membres

Jean-François QUIGNARD

Parcours professionnel

Publications 50

Genetically-encoded BRET probes shed light on ligand bias–induced variable ion selectivity in TRPV1 and P2X5/7

Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism

Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca2+ Influx and Akt-eNOS Pathway

Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia

NiONP-Induced Oxidative Stress and Mitochondrial Impairment in an In Vitro Pulmonary Vascular Cell Model Mimicking Endothelial Dysfunction

Implication des canaux mécanosensibles Piezo1 et TRPV4 dans l’hypertension pulmonaire

Muscarinic receptor M3 activation promotes fibrocytes contraction

Effects of FW2 Nanoparticles Toxicity in a New In Vitro Pulmonary Vascular Cells Model Mimicking Endothelial Dysfunction

NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption

Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension

High-Throughput Screening of TRPV1 Ligands in the Light of the Bioluminescence Resonance Energy Transfer Technique

TRPV4 channel mediates adventitial fibroblast activation and adventitial remodeling in pulmonary hypertension

CD95/Fas and metastatic disease: What does not kill you makes you stronger

In vitro study of carbon black nanoparticles on human pulmonary artery endothelial cells: effects on calcium signaling and mitochondrial alterations

Stretch-activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries

The ellagitannin metabolite urolithin C is a glucose-dependent regulator of insulin secretion through activation of L-type calcium channels

Tribute to Paul M. Vanhoutte, MD, PhD (1940-2019)

HMGB1 down-regulation mediates terameprocol vascular anti-proliferative effect in experimental pulmonary hypertension

Altered vasoreactivity in neonatal rats with pulmonary hypertension associated with bronchopulmonary dysplasia: Implication of both eNOS phosphorylation and calcium signaling

Involvement of oxidative stress and calcium signaling in airborne particulate matter – induced damages in human pulmonary artery endothelial cells

T-type voltage gated calcium channels are involved in endothelium-dependent relaxation of mice pulmonary artery

Calcium signalling induced by in vitro exposure to silicium dioxide nanoparticles in rat pulmonary artery smooth muscle cells.

The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells.

Caveolae are involved in mechanotransduction during pulmonary hypertension.

Effect of hypoxia on TRPV1 and TRPV4 channels in rat pulmonary arterial smooth muscle cells.

T-type calcium channels are involved in hypoxic pulmonary hypertension.

Stretch-induced Ca2+ signalling in vascular smooth muscle cells depends on Ca2+ store segregation.

Protease activated receptor-2 expression and function in asthmatic bronchial smooth muscle.

Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells.

Beneficial effect of dehydroepiandrosterone on pulmonary hypertension in a rodent model of pulmonary hypertension in infants.

Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.

Dehydroepiandrosterone (DHEA) inhibits voltage-gated T-type calcium channels.

Stretch-activated channels in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.

Quercetin potentiates insulin secretion and protects INS-1 pancreatic β-cells against oxidative damage via the ERK1/2 pathway.

Intracellular Ca(2+) oscillations induced by over-expressed Ca(V)3.1 T-type Ca(2+) channels in NG108-15 cells.

Subunit-specific modulation of T-type calcium channels by zinc.

T-type CaV3.3 calcium channels produce spontaneous low-threshold action potentials and intracellular calcium oscillations.

K+ channels in cultured bovine retinal pericytes: effects of beta-adrenergic stimulation.

Stimulation of L-type Ca2+ channels by inositol pentakis- and hexakisphosphates in rat vascular smooth muscle cells.

Endothelium-dependent hyperpolarization to acetylcholine in carotid artery of guinea pig: role of lipoxygenase.

Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels.

Phosphoinositide 3-kinase gamma mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes.

Transient down-regulation of L-type Ca(2+) channel and dystrophin expression after balloon injury in rat aortic cells.

[Is atypical sodium current related to arterial pathophysiology?]

3-Morpholinosydnonimine (SIN-1) and K(+) channels in smooth muscle cells of the rabbit and guinea pig carotid arteries.

Role of endothelial cell hyperpolarization in EDHF-mediated responses in the guinea-pig carotid artery.

Regulation of Ca2+ homeostasis by atypical Na+ currents in cultured human coronary myocytes.

Potassium ions and endothelium-derived hyperpolarizing factor in guinea-pig carotid and porcine coronary arteries.

A novel tetrodotoxin-sensitive Na+ current in cultured human coronary myocytes.

Voltage-gated calcium channel currents in human coronary myocytes. Regulation by cyclic GMP and nitric oxide.

Équipe

Physiopathologie de la circulation pulmonaire