Christelle GUIBERT

INSERM Research Director / Manager of the team 1

Professional background

Since 2025 Coordinator of the RESPIrenT group (RESeau de Pneumologie en Innovation et Recherche translaTionnelle)

Since 2023 Research director (INSERM), CRCTB – INSERM U1045

Since 2016 Director of the Pathophysiology of the pulmonary circulation team (CRCTB, INSERM U1045), University of Bordeaux

2000 – 2023 Research officer (INSERM), Centre de Recherche Cardio-Thoracique de Bordeaux (CRCTB) – INSERM U1045

2005 6 months in the laboratory of Pr E. Rousseau – Department of Physiology and biophysics – Sherbrooke – Canada

1997 – 2000 Post-doctoral researcher, School of Biomedical Sciences (Laboratory of Pr D.J. Beech)– Leeds – England

1997 Post-doctoral researcher, Institut de Pharmacologie Moléculaire et Cellulaire (IPMC) – CNRS – Sophia-antipolis – France

1997 PhD in biological and medical sciences, University of Bordeaux

Funding

Hemangiol patent royalties (2020 – 2029)
Prematuration grant (2025 – 2026)
ANRT – CIFRE grant (2019 – 2023)
Fondation du souffle (2020-2022)
Fondation Bordeaux Université – fonds pour les maladies chroniques (2019-2020)

Patents

2022 – OP2113 in the vasculitides (PCT/EP2022/068064)
2017 – OP2113 and its potential applications in various pathologies, including pulmonary hypertension and pulmonary arterial hypertension (WO 2017/0422671A1)

Members

Christelle GUIBERT

Professional background

Funding

Patents

Publications 65

Celastrol has beneficial effects on pulmonary hypertension associated with bronchopulmonary dysplasia: Preclinical study outcomes

NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity

The effect of CGRP and SP and the cell signaling dialogue between sensory neurons and endothelial cells

OP2113, a new drug for chronic hypoxia‐induced pulmonary hypertension treatment in rat

Editorial: Model organisms and experimental models: opportunities and challenges in vascular physiology research

Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism

Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca2+ Influx and Akt-eNOS Pathway

Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia

Cellular and molecular mechanisms of NiONPs toxicity on eel hepatocytes HEPA-E1: An illustration of the impact of Ni release from mining activity in New Caledonia.

NiONP-Induced Oxidative Stress and Mitochondrial Impairment in an In Vitro Pulmonary Vascular Cell Model Mimicking Endothelial Dysfunction

NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption.

Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension

Effects of FW2 Nanoparticles Toxicity in a New In Vitro Pulmonary Vascular Cells Model Mimicking Endothelial Dysfunction.

Hydrogen Sulfide Metabolism and Pulmonary Hypertension

In vitro study of carbon black nanoparticles on human pulmonary artery endothelial cells: effects on calcium signaling and mitochondrial alterations.

Connexin-43 is a promising target for pulmonary hypertension due to hypoxaemic lung disease.

TRPV4 channel mediates adventitial fibroblast activation and adventitial remodeling in pulmonary hypertension

TRPV4 channel mediates adventitial fibroblast activation and adventitial remodeling in pulmonary hypertension.

Stretch-activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries

Stretch-activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries.

ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension.

Involvement of oxidative stress and calcium signaling in airborne particulate matter – induced damages in human pulmonary artery endothelial cells

Altered vasoreactivity in neonatal rats with pulmonary hypertension associated with bronchopulmonary dysplasia: Implication of both eNOS phosphorylation and calcium signaling

Chronic hypoxia aggravates monocrotaline-induced pulmonary arterial hypertension: a rodent relevant model to the human severe form of the disease

Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries

Expression and role of connexin-based gap junctions in pulmonary inflammatory diseases.

Hypoxia/Hypercapnia-Induced Adaptation Maintains Functional Capacity of Cord Blood Stem and Progenitor Cells at 4 degrees C

The influence of gap junction network complexity on pulmonary artery smooth muscle reactivity in normoxic and chronically hypoxic conditions

Mitochondria: Roles in pulmonary hypertension

Reactive oxygen species as therapeutic targets in pulmonary hypertension

Development and Characterization of an Animal Model of Severe Pulmonary Arterial Hypertension

Effect of chronic hypoxia on pulmonary artery blood velocity in rats as assessed by electrocardiography-triggered three-dimensional time-resolved MR angiography

Expression and Physiological Roles of TRP Channels in Smooth Muscle Cells

Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice

Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension

Plasma membrane Ca2+-ATPase equals no NO

Effect of engineered nanoparticles on vasomotor responses in rat intrapulmonary artery

Circulating Microparticles from Pulmonary Hypertensive Rats Induce Endothelial Dysfunction

Signalling pathways involved in the contractile response to 5-HT in the human pulmonary artery

Vascular Smooth Muscle Modulates Endothelial Control of Vasoreactivity via Reactive Oxygen Species Production through Myoendothelial Communications

Vascular smooth muscle cells limit endothelial control of vasoreactivity via ROS production through myoendothelial communications

Effects of omega-hydroxylase product on distal human pulmonary arteries

Voltage-independent calcium influx in smooth muscle

Serotonin-induced activation of TRPV4-like current in rat intrapulmonary arterial smooth muscle cells

Heterogeneity in 5-HT-induced contractile and proliferative responses in rat pulmonary arterial bed.

Modulation of ion channels in pulmonary arterial hypertension.

Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries

Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries

Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation

Effect of short-term organoid culture on the pharmaco-mechanical properties of rat extra- and intrapulmonary arteries

5-HT induces an arachidonic acid-sensitive calcium influx in rat small intrapulmonary artery

Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery

Hepatitis C virus proteins do not directly trigger fibrogenic events in cultured human liver myofibroblasts

Prevention of a hypoxic Ca-i(2+) response by SERCA inhibitors in cerebral arterioles

Sodium-potassium-ATPase electrogenicity in cerebral precapillary arterioles.

Sodium-potassium-ATPase electrogenicity in cerebral precapillary arterioles

Positive and negative coupling of the endothelin ETA receptor to Ca2+-permeable channels in rabbit cerebral cortex arterioles

Cellular mechanisms and role of endothelin-1-induced calcium oscillations in pulmonary arterial myocytes

Dependence of P2-nucleotide receptor agonist-mediated endothelium-independent relaxation on ectonucleotidase activity and A(2A)-receptors in rat portal vein

Ca2+ (i) oscillations induced by muscarinic stimulation in airway smooth muscle cells: Receptor subtypes and correlation with the mechanical activity

Oscillatory Cl- current induced by angiotensin II in rat pulmonary arterial myocytes: Ca2+ dependence and physiological implication

Angiotensin II-induced Ca2+-oscillations in vascular myocytes from the rat pulmonary artery

Effect of extracellular ATP on cytosolic Ca2+ concentration in rat pulmonary artery myocytes

Human and rat airway smooth muscle responsiveness after ozone exposure in vitro

Variability of intracellular calcium concentrations caused by muscarin stimulation in isolated myocytes of the rat trachea: Subtypes of receptors involved and correlation with contraction

Team

Pathophysiology of the pulmonary circulation