Members

Isabelle DUPIN

Group leader (Interdisciplinary approaches for COPD understanding)

Email : [email protected]
ORCID : 0000-0002-4992-9625

Professional background

2023 – 2028         Fondamental Junior Chair (5-years position), Institut Universitaire de France (IUF)

Since 2021           Professor of Physiology, CRCTB, INSERM U1045, Université de Bordeaux

2014 – 2021         Assistant Professor, CRCTB, INSERM U1045, Université de Bordeaux

2013 – 2014        University Hospital Assistant, CRCTB, INSERM U1045, Université de Bordeaux

2010 – 2013        Postdoctoral Researcher, Interdisciplinary Institute for Neuroscience, UMR 5297, Université de Bordeaux

Funding

ERC Consolidator grant (2025-30, KINTSUGI project)

IUF Junior Chair (2023-2028)

ANR Jeunes Chercheurs– Jeunes Chercheuses (2022-25, BRONCHIOLE project)

AAP ESR 2022 Région Nouvelle Aquitaine (2022)

Fondation Bordeaux Université-Fonds pour les Maladies Chroniques (2020)

Fondation Bordeaux Université-Fonds pour les Maladies Chroniques (2017)

Patents

Berger P, Dupin I, Girodet P.O. New compositions and methods for treating and/or preventing Chronic Obstructive Pulmonary Disease. Patent filed on 28/01/2015 (15152886.6), granted by the European Patent Office on 09/10/2019 under number EP 3050574.

Berger P, Bismuth K, Dupin I, Girodet P.O., James C, Prevel R, Rattenbach R. New compositions and methods for treating COVID-19 disease. Patent filed on 07/05/2020 under number EP20173595.8. Licensed.

Publications 29

August 2025 American Journal of Physiology-Lung Cellular and Molecular Physiology

Understanding and manipulating morphogenetic processes to generate in vitro models of airways

Authors : Katharina Raasch, Pauline Henrot, Alice Hadchouel-Duvergé, Maeva Zysman, Isabelle Dupin
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December 2024 European Respiratory Journal

A novelin vitrotubular model to recapitulate features of distal airways: the bronchioid

Authors : Elise Maurat, Katharina Raasch, Alexander M. Leipold, Pauline Henrot, Maeva Zysman, Renaud Prevel, Thomas Trian, Tobias Krammer, Vanessa Bergeron, Matthieu Thumerel, Pierre Nassoy, Patrick Berger, Antoine-Emmanuel Saliba, Laetitia Andrique, Gaëlle Recher, Isabelle Dupin
Read more
September 2023 European Respiratory Review

Innovative three-dimensional models for understanding mechanisms underlying lung diseases: powerful tools for translational research

Authors : Mehmet Nizamoglu, Mugdha M. Joglekar, Catarina R. Almeida, Anna-Karin Larsson Callerfelt, Isabelle Dupin, Olivier T. Guenat, Pauline Henrot, Lisette van Os, Jorge Otero, Linda Elowsson, Ramon Farre, Janette K. Burgess
Read more
January 2023 bioRxiv

CXCR4 blockade alleviates pulmonary and cardiac outcomes in young COPD

Authors :
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January 2023 Journal of Theoretical Biology

Probabilistic cellular automata modelling of intercellular interactions in airways: complex pattern formation in patients with chronic obstructive pulmonary disease

Authors : Dupin, I., Eyraud, E., Maurat, É., Sac-Épée, J.-M., Vallois, P.
Read more
March 2022 Cell Reports

Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epithelium

Authors : Pauline Esteves, Benoit Allard, Alexis Celle, Isabelle Dupin, Elise Maurat, Olga Ousova, Matthieu Thumerel, Jean-William Dupuy, Thierry Leste-Lasserre, Roger Marthan, Pierre-Olivier Girodet, Thomas Trian, Patrick Berger
Read more
January 2022 Pédagogie Médicale

Première année de fonctionnement du parcours accès spécifique santé (PASS) de l’Université de Bordeaux : caractérisation et identification des facteurs de réussite pour la validation du PASS et l’entrée dans la filière médecine

Authors : Isabelle Dupin, Séverine Barandon, Caroline Bertrand, Laurence Bordenave, Véronique Chassaing, Jean-Benoît Corcuff, Pierre Dubus, Noémie C. DUCLOS, Jean Guillon, Maria Mamani-Matsuda, Bernard Müller, Jean-Luc Pellegrin, Amadou Alioum
Read more
September 2021 Respirology

Unravelling the effects of omalizumab on fibrocytes

Authors : Patrick Berger, Isabelle Dupin
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January 2021 European Respiratory Journal

Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling

Authors : Esteves, P., Blanc, L., Celle, A., Dupin, I., Maurat, E., Amoedo, N., Cardouat, G., Ousova, O., Gales, L., Bellvert, F., Begueret, H., Thumerel, M., Dupuy, J.-W., Desbenoit, N., Marthan, R., Girodet, P.-O., Rossignol, R., Berger, P., Trian, T.
Read more
December 2019 Respiratory Research

Determination of reliable lung function parameters in intubated mice

Authors : Eline Bonnardel, Renaud Prevel, Marilyne Campagnac, Marielle Dubreuil, Roger Marthan, Patrick Berger, Isabelle Dupin
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June 2019 International Journal of Molecular Sciences

Chemokines in COPD: From Implication to Therapeutic Use

Authors : Pauline Henrot, Renaud Prevel, Patrick Berger, Isabelle Dupin
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January 2019 European Respiratory Journal

Fibrocyte accumulation in the airway walls of COPD patients

Authors : Dupin, I., Thumerel, M., Maurat, E., Coste, F., Eyraud, E., Begueret, H., Trian, T., Montaudon, M., Marthan, R., Girodet, P.-O., Berger, P.
Read more
October 2017 American Journal of Respiratory Cell and Molecular Biology

Fibrocytes in Asthma and COPD: Variations on the Same Theme

Authors : Isabelle Dupin, Cécile Contin-Bordes, Patrick Berger
Read more
May 2016 Journal of Allergy and Clinical Immunology

Reply

Authors : Isabelle Dupin, Pierre-Olivier Girodet, Patrick Berger
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March 2016 American Journal of Respiratory and Critical Care Medicine

Bronchial Smooth Muscle Remodeling in Nonsevere Asthma

Authors : Pierre-Olivier Girodet, Benoit Allard, Matthieu Thumerel, Hugues Begueret, Isabelle Dupin, Olga Ousova, Régis Lassalle, Elise Maurat, Annaig Ozier, Thomas Trian, Roger Marthan, Patrick Berger
Read more
January 2016 Journal of Allergy and Clinical Immunology

Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients

Authors : Trian, T., Allard, B., Ozier, A., Maurat, E., Dupin, I., Thumerel, M., Ousova, O., Gillibert-Duplantier, J., Le Morvan, V., Begueret, H., Girodet, P.-O., Marthan, R., Berger, P.
Read more
October 2015 The Journal of allergy and clinical immunology

Blood fibrocytes are recruited during acute exacerbations of chronic obstructive pulmonary disease through a CXCR4-dependent pathway.

Authors :
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September 2015 3.2 Airway Cell Biology and Immunopathology

The critical role of bronchial smooth muscle remodeling in non-severe asthma

Authors : Pierre-Olivier Girodet, Benoit Allard, Matthieu Thumerel, Hugues Begueret, Isabelle Dupin, Olga Ousova, Elise Maurat, Annaig Ozier, Thomas Trian, Roger Marthan, Patrick Berger
Read more
September 2015 3.3 Mechanisms of Lung Injury and Repair

Recruitment of blood fibrocytes during acute exacerbations of chronic obstructive pulmonary disease through a CXCR4 dependent pathway

Authors : Isabelle Dupin, Benoît Allard, Annaïg Ozier, Elise Maurat, Olga Ousova, Thomas Trian, Hoang-Nam Bui, Claire Dromer, Olivier Guisset, Elodie Blanchard, Gilles Hibert, Frédérique Vargas, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger
Read more
September 2015 3.2 Airway Cell Biology and Immunopathology

p53 dysfunction increased mitochondrial biogenesis and bronchial smooth muscle cell proliferation in asthma

Authors : Thomas Trian, Benoit Allard, Elise Maurat, Isabelle Dupin, Olga Ousova, Pierre-Olivier Girodet, Roger Marthan, Patrick Berger
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April 2015 American Journal of Respiratory and Critical Care Medicine

Calcium channel blocker reduces airway remodeling in severe asthma. A proof-of-concept study.

Authors :
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March 2015 Current Protocols in Cell Biology

Adhesive Micropatterns to Study Intermediate Filament Function in Nuclear Positioning

Authors : Isabelle Dupin, Julien Elric, Sandrine Etienne-Manneville
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March 2015 American Journal of Respiratory and Critical Care Medicine

House Dust Mites Induce Proliferation of Severe Asthmatic Smooth Muscle Cells via an Epithelium-Dependent Pathway

Authors : Thomas Trian, Benoit Allard, Isabelle Dupin, Gabrielle Carvalho, Olga Ousova, Elise Maurat, Jehan Bataille, Matthieu Thumerel, Hugues Begueret, Pierre-Olivier Girodet, Roger Marthan, Patrick Berger
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March 2015 Neural Development

Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons

Authors : Isabelle Dupin, Ludmilla Lokmane, Maxime Dahan, Sonia Garel, Vincent Studer
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November 2013 Journal of Neuroscience

Investigating Axonal Guidance with Microdevice-Based Approaches

Authors : I. Dupin, M. Dahan, V. Studer
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October 2012 Biophysical Journal

Amplification and Temporal Filtering during Gradient Sensing by Nerve Growth Cones Probed with a Microfluidic Assay

Authors : Mathieu Morel, Vasyl Shynkar, Jean-Christophe Galas, Isabelle Dupin, Cedric Bouzigues, Vincent Studer, Maxime Dahan
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March 2011 Journal of Cell Science

Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleus

Authors : I. Dupin, Y. Sakamoto, S. Etienne-Manneville
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January 2011 The International Journal of Biochemistry & Cell Biology

Nuclear positioning: Mechanisms and functions

Authors : Isabelle Dupin, Sandrine Etienne-Manneville
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June 2009 The Journal of Cell Biology

Classical cadherins control nucleus and centrosome position and cell polarity

Authors : Isabelle Dupin, Emeline Camand, Sandrine Etienne-Manneville
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Team

Team 2

Bronchial remodeling

The study of the mechanisms and treatments of bronchial remodeling in asthma and chronic bronchitis is at the heart of this team's work. It has recognized expertise in epithelium-muscle interactions, functional imaging and clinical research.

Leadership : Patrick BERGER