Josquin COURTE

Preclinical Research Scientist

Professional background

  • 2025- (current position) Preclinical Research Scientist with 4Living Biotech, a spin-off from 4P Pharma. Posted in Inserm U1045 in the context of a private-public partnership for project 4P021. CHOPIN study: disease biomarkers identification for Acute Respiratory Distress Syndrome (ARDS) patients. Advanced in vitro ARDS model development (NAMs, MPS).
  • 2021-2024 Postdoctoral Research Scientist at the University of Southern California (Los Angeles), Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Morsut lab. Self-organized tissue engineering through the design of synthetic gene circuits.
  • 2019-2020 Postdoctoral Research Scientist at Institut Pierre-Gilles de Gennes (Institut Curie and CNRS, Paris). Development of methods for the fabrication of microfluidic systems with thermoplastics (EU HoliFab project, private-public partnership).
  • 2015-2019 PhD Student between Institut de Biologie Paris-Seine and l’Institut Pierre-Gilles de Gennes (Institut Curie and CNRS, Paris). In vitro modelling of Parkinson’s disease with microfluidic culture systems for the reconstruction of topologically defined neural networks.
  • 2015 Master diploma, Cellular Neuroscience, Sorbonne Université.
  • 2015 Master (“Ingénieur”/Engineer certification), Medical Biotechnologies, Sup’Biotech Paris.

Publications 10

December 2024

Programming the elongation of mammalian cell aggregates with synthetic gene circuits

Authors : Josquin Courte, Christian Chung, Naisargee Jain, Catcher Salazar, Neo Phuchane, Steffen Grosser, Calvin Lam, Leonardo Morsut
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November 2024 Nature Communications

Control of spatio-temporal patterning via cell growth in a multicellular synthetic gene circuit

Authors : Marco Santorelli, Pranav S. Bhamidipati, Josquin Courte, Benjamin Swedlund, Naisargee Jain, Kyle Poon, Dominik Schildknecht, Andriu Kavanagh, Victoria A. MacKrell, Trusha Sondkar, Mattias Malaguti, Giorgia Quadrato, Sally Lowell, Matt Thomson, Leonardo Morsut
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October 2023 Cellular and Molecular Life Sciences

Synapses do not facilitate prion-like transfer of alpha-synuclein: a quantitative study in reconstructed unidirectional neural networks

Authors : Josquin Courte, Ngoc Anh Le, Teng Pan, Luc Bousset, Ronald Melki, Catherine Villard, Jean-Michel Peyrin
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January 2023 Methods in Molecular Biology

Propagation of Distinct α-Synuclein Strains Within Human Reconstructed Neuronal Network and Associated Neuronal Dysfunctions

Authors : Simona Gribaudo, Luc Bousset, Josquin Courte, Ronald Melki, Jean-Michel Peyrin, Anselme L. Perrier
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April 2022 ACS Synthetic Biology

Parameterized Computational Framework for the Description and Design of Genetic Circuits of Morphogenesis Based on Contact-Dependent Signaling and Changes in Cell–Cell Adhesion

Authors : Calvin Lam, Sajeev Saluja, George Courcoubetis, Dottie Yu, Christian Chung, Josquin Courte, Leonardo Morsut
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October 2021

Quantitative study of alpha-synuclein prion-like spreading in fully oriented reconstructed neural networks reveals non-synaptic dissemination of seeding aggregates

Authors : Josquin Courte, Ngoc Anh Le, Luc Bousset, Ronald Melki, Catherine Villard, Jean-Michel Peyrin
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December 2020 Scientific Reports

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Authors :
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July 2018 Cellular and Molecular Life Sciences

Cellular mechanisms responsible for cell-to-cell spreading of prions

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January 2018 Neurotoxicity Research

Neurotoxicity of the Cyanotoxin BMAA Through Axonal Degeneration and Intercellular Spreading

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January 2018 Methods in Cell Biology

Reconstruction of directed neuronal networks in a microfluidic device with asymmetric microchannels

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