Rémi DUBOIS

Professor

Professional background

• Since 2020 – Full Professor (PR1C, section 61), University of Bordeaux; Head of the Signal Processing Team at IHU LIRYC.
• 2015 – 2022: Director of Innovation, IHU LIRYC.
• 2018 – 2020: Contract researcher, University of Bordeaux; Head of the Signal Processing Team at IHU LIRYC.
• 2012 – 2015: Head of technology transfer / valorization, IHU LIRYC.
• 2008 – 2018: Tenured Associate Professor (Maître de Conférences), SIGMA Lab, ESPCI-ParisTech.
• 2007: Temporary Teaching and Research Assistant (ATER), Electronics Lab, ESPCI.
• 2006: Postdoctoral fellow, INAPG-INRA / ESPCI – modelling of the olfactory system.
• 2004 – 2005: Co-founder of the Ciprian start-up (data analysis, signal processing and digital instrumentation).
• 2000 – 2004: PhD candidate (MENRT fellowship), SIGMA Lab, ESPCI – Machine-learning algorithms for the detection of cardiac arrhythmias.
Degrees & qualifications
• 2019: National qualification as Full Professor, sections 61 and 63.
• 2013: National qualification as Full Professor, section 61.
• 2012: Habilitation à Diriger des Recherche (HDR), Université Pierre-et-Marie-Curie, Paris VI – “New signal-processing methods applied to computer-aided diagnosis in cardiology”.
• 2007: National qualification as Associate Professor, section 61.
• 2000 – 2004: PhD, Université Pierre-et-Marie-Curie (Paris VI), Electronics – SIGMA Lab, ESPCI-ParisTech.
• 1999 – 2000: DEA in Electronics (Electronics and Instrumentation), ESPCI / UPMC.
• 1997 – 2000: Engineering degree (M.Eng.), ISEP – Institut Supérieur d’Électronique de Paris.

Funding

• 2020 – 2023: Co-Investigator, HELP project – sudden cardiac death risk stratification (€1.5M).
• 2019 – 2022: Co-Investigator, ANR MAESTRO (€600k).
• 2019 – 2022: SIMRIC project – cardiac electrophysiology training simulator (€100k).
• 2019 – 2020: Quick-eCG – ECG recorder development (€80k).
• 2019: Principal Investigator, Région Nouvelle-Aquitaine SIMRIC grant (€180k, two post-doctoral fellowships + equipment).
• 2018 – 2023: Work-package leader, ERC Starting Grant ECSTATIC (PI: Prof. Hubert Cochet).
• 2018 – 2021: Collaborator, ANR unMask.
• 2017 – 2022: Principal Investigator of WP3, Leducq Foundation – RHYTHM (total budget €4.5M, €930k for WP3).
• 2016 – 2019: Scientific lead, research agreement with CardioInsight (Cleveland, OH, USA) – €1M.
• 2016 – 2019 (renewable): Lead of a research agreement with Biosense-Webster.
• 2015 – 2019: Principal Investigator, Cœur et Artères Foundation grant (NovelECGI).
• 2014 – 2016: Principal Investigator, IDEX Bordeaux SIMRIC grant (€200k).
• 2012 – 2018: Participation in EQUIPEX MUSIC.
• Earlier: Scientific lead of a research agreement with AMPS LLC (New York); two CIFRE agreements with Sorin Group (2007-2010 and 2011-2014); participation in ANR OUISPER, REVOIX and ARC FIBAUR (INRIA South-West), and in the Fluorescence digital video imaging project (Pierre-Gilles de Gennes Foundation).

Patents

• Ploux S., Strik M., Bordachar P., Dubois R. — Procédé d’attribution d’une information d’identification à un signal d’une électrode cardiaque, FR2104376 (2021).
• Dubois R., Haïssaguerre M., Bernus O., Bear L., Tan N. — Procédé de sélection de descripteurs électrophysiologiques, FR2103047 (2021).
• Dubois R., Haïssaguerre M., Bernus O., Bear L., Tan N. — Méthode de détection d’une indication spatiale représentative d’une activité électrique singulière du myocarde, FR2103044 (2021).
• Dubois R., Dallet C. — Conduction velocity and pattern mapping, US Patent 10,959,638 (2021).
• Dubois R., Jaïs P. — Single-shot electroporation catheter for PVI and linear lesions, FR2014047 (2020).
• Basu S., Bar-Tal M., Solis M.A., Haïssaguerre M., Jaïs P., Hocini M., Bernus O., Dubois R., Takigawa M. — Electrode configurations for diagnosis of arrhythmias, US Patent App. 16/820,848 (2020).
• Jaïs P., Dubois R., Leeflang S.A., Eversull C.S. — Devices, systems, and methods for improving the accuracy and utility of imaging for cardiovascular procedures, US Patent App. 16/435,270 (2020).
• Zeng Q., Ramanathan C., Vasudevan V., Dubois R., Jia P. — Multi-parameter physiological mapping, US Patent App. 16/659,154 (2020) ; suite : Multi-parameter physiological mapping to a multi-dimensional color model, US Patent 11,880,955 (2024).
• Dubois R. — Procédé de simulation d’une dynamique respiratoire d’un poumon virtuel, simulateur virtuel, ensemble respiratoire, FR1771004 (2017 ; phase nationale 03/2020).
• Dubois R. — Système de navigation et de cartographie pour cathéter, FR1756842 (2017).
• Hooks D., Dubois R., Meillet V. — Monitoring system for ablation of cardiac tissue in close proximity to the AV node and for generating a sensorial alert, EP16306464 (2016).
• Hooks D., Dubois R., Meillet V. — System for automated rhythm-based control of cardiac ablation close to the atrioventricular node, EP15305689 (2015).
• Marquet F., Quesson B., Bour P., Vaillant F., Dubois R. — Méthode de contrôle pour la calibration d’un faisceau ultrasonore focalisé pour la stimulation cardiaque, FR1458210 (2014).
• Dubois R., George B. — Signal averaging for reducing noise in ECG, PCT/US2012/036543 (2012).
• Dubois R., Wodlinger H., Ramanathan C., George B., Roussel-Ragot P. — System and methods for computing activation maps, PCT/US2011/051954 (2011).
• Hueber T., Denby B., Dubois R., Roussel P., Dreyfus G. — Dispositif de reconstitution de la parole par sondage ultrasonore de l’appareil phonatoire, FR2950189 (EP/US, 2010).
• Bouchet P., Dubois R., Dreyfus G., Henry C. — Défibrillateur/cardioverteur implantable simple chambre avec détection de l’activité auriculaire par la sonde monocorps, FR0958898 (FR/EP, 2009).
• Bouchet P., Dubois R., Henry C., Dreyfus G., Dal Molin R., El Arab J. — Dispositif médical actif comprenant des moyens perfectionnés de discrimination entre tachycardies d’origine ventriculaire et supraventriculaire, FR2105843 (EP/US, 2009).
• Dubois R., MacAdam D.P., Mashimo M., Fanier S., Collins T., He D.S. — High-density atrial fibrillation cycle length (AFCL) detection and mapping system, EP1746933 (US/EU, 2005).
• Dubois R., Quenet B., Faisandier Y. — Dispositif d’analyse d’un signal, notamment d’un signal physiologique tel qu’un signal ECG, FR2847361 (EP/US, 2004).

Members

Rémi DUBOIS

Professional background

Funding

Patents

Publications 118

A Multi-Center Trained Residual Neural Network for Robust Classification of Atrial High-Rate Episodes in Remotely Monitored Pacemakers and Defibrillators

Bronchial smooth muscle extracellular vesicles interfere with bronchial epithelium metabolism and function in asthma

Editorial: Advances in artificial intelligence-enhanced electrocardiography: a pathway towards improved diagnosis and patient care

Reconstructing ECG from indirect signals: a denoising diffusion approach

ECG electrode localization using 3D visual reconstruction

Leveraging an ECG Beat Diffusion Model for Morphological Reconstruction from Indirect Signals

A deep learning modular ECG approach for cardiologist assisted adjudication of atrial fi brillation and atrial fl utter episodes

mDAE : modified Denoising AutoEncoder for missing data imputation

Artificial intelligence for detection of ventricular oversensing: Machine learning approaches for noise detection within nonsustained ventricular tachycardia episodes remotely transmitted by pacemakers and implantable cardioverter-defibrillators

Investigation into the importance of using natural PVCs and pathological models for potential-based ECGI validation

Atrial Periodic Source Spectrum From Preoperative Body Surface Potentials Predicts Long-Term Recurrence of Atrial Fibrillation

Using a Smartwatch to Record Precordial Electrocardiograms: A Validation Study

24-Hour Monitoring of Intraocular Pressure Fluctuations Using a Contact Lens Sensor: Diagnostic Performance for Glaucoma Progression

High-resolution mapping of reentrant atrial tachycardias: Relevance of low bipolar voltage

Bayesian ECG reconstruction using denoising diffusion generative models

Basis and applicability of noninvasive inverse electrocardiography: a comparison between cardiac source models

Multisite conduction block in the epicardial substrate of Brugada syndrome

Steep repolarization time gradients in pig hearts cause distinct changes in composite electrocardiographic T-wave parameters

Electrocardiographic Imaging of Repolarization Abnormalities

Noninvasive detection of spatiotemporal activation-repolarization interactions that prime idiopathic ventricular fibrillation

Ultralow temperature cryoablation: Safety and efficacy of preclinical atrial and ventricular lesions

Benchmark of deep learning algorithms for the automatic screening in electrocardiograms transmitted by implantable cardiac devices

3-Dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance

A novel method to correct repolarization time estimation from unipolar electrograms distorted by standard filtering

Automated rhythm-based control of radiofrequency ablation close to the atrioventricular node: Preclinical, animal, and first-in-human testing

Early Signs of Critical Slowing Down in Heart Surface Electrograms of Ventricular Fibrillation Victims

Insights Into the Spatiotemporal Patterns of Complexity of Ventricular Fibrillation by Multilead Analysis of Body Surface Potential Maps

Body Surface Mapping of Ventricular Repolarization Heterogeneity: AnEx-vivoMultiparameter Study

Long-Lasting Ventricular Fibrillation in Humans ECG Characteristics and Effect of Radiofrequency Ablation

Relation of Surface T-wave to Vulnerability to Ventricular Fibrillation in Explanted Structurally Normal Hearts

Idiopathic Ventricular Fibrillation Role of Purkinje System and Microstructural Myocardial Abnormalities

Solving the ECGI Problem with Known Locations of Scar Regions

New Insights Into Non-Invasive His Bundle Potential Detection on High Resolution Body Surface Recordings

Impaired Body Surface Electrode Contact Reduces Accuracy of Non-Invasive Electrocardiographic Imaging

A Patchwork Inverse Method in Combination With the Activation Time Gradient to Detect Regions of Slow Conduction in Sinus Rhythm

Electrogram morphology discriminators in implantable cardioverter defibrillators: A comparative evaluation

Optical Imaging of Ventricular Action Potentials in a Torso Tank: A New Platform for Non-Invasive Electrocardiographic Imaging Validation

Depolarization versus repolarization abnormality underlying inferolateral J-wave syndromes: New concepts in sudden cardiac death with apparently normal hearts

Advantages and pitfalls of noninvasive electrocardiographic imaging

Performance and limitations of noninvasive cardiac activation mapping

Adriaan van Oosterom, PhD IN MEMORY

Effect of Activation Wavefront on Electrogram Characteristics During Ventricular Tachycardia Ablation

Considering New Regularization Parameter-Choice Techniques for the Tikhonov Method to Improve the Accuracy of Electrocardiographic Imaging

Impact of the Endocardium in a Parameter Optimization to Solve the Inverse Problem of Electrocardiography

Characterizing localized reentry with high-resolution mapping: Evidence for multiple slow conducting isthmuses within the circuit

Cardiac Propagation Pattern Mapping With Vector Field for Helping Tachyarrhythmias Diagnosis With Clinical Tridimensional Electro-Anatomical Mapping Tools

Universal atrial coordinates applied to visualisation, registration and construction of patient specific meshes

Reply to the Editor-Interpretation of electrograms is key to understand the clinical potential of ECGi

Reply to the Editor-Performance and limitations of noninvasive cardiac activation mapping

Cardiac electrical dyssynchrony is accurately detected by noninvasive electrocardiographic imaging

Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced Cardiac Magnetic Resonance and Re-Entrant Activity Assessed With Electrocardiographic Imaging in Human Persistent Atrial Fibrillation

Localized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death

Universal atrial coordinates applied to visualisation, registration and construction of patient specific meshes

Atrial Fibrillation Spatiotemporal Complexity Is Affected by Pulmonary Vein Isolation

Fast personalized electrophysiological models fromcomputed tomography images for ventricular tachycardia ablation planning

Characteristics of Scar-Related Ventricular Tachycardia Circuits Using Ultra-High-Density Mapping: A Multi-Center Study

Mapping and Ablation of Idiopathic Ventricular Fibrillation

Wavelength and Fibrosis Affect Phase Singularity Locations During Atrial Fibrillation

Noninvasive Assessment of Atrial Fibrillation Complexity in Relation to Ablation Characteristics and Outcome

Response to cardiac resynchronization therapy is determined by intrinsic electrical substrate rather than by its modification

Variability in pulmonary vein electrophysiology and fibrosis determines arrhythmia susceptibility and dynamics

Comparing Reentrant Drivers Predicted by Image-Based Computational Modeling and Mapped by Electrocardiographic Imaging in Persistent Atrial Fibrillation

High-density mapping of atrial tachycardias: Importance of interpolation

Atrial tachycardias: Cause or effect with ablation of persistent atrial fibrillation?

Management of Polypoid Gallbladder Lesions in Children: A Multicenter Study

Complexity and Distribution of Drivers in Relation to Duration of Persistent Atrial Fibrillation

The Combination of Pulmonary Vein Electrophysiology and Atrial Fibrosis Determines Driver Location

Application of an Inverse-Forward Approach to Derive the 12-lead ECG from Body Surface Potential Maps

Non-Invasive Assessment of Spatiotemporal Organization of Ventricular Fibrillation Through Principal Component Analysis

Cardiac Imaging in Patients With Ventricular Tachycardia

A Parameter Optimization to Solve the Inverse Problem in Electrocardiography

Improving the Spatial Solution of Electrocardiographic Imaging: A New Regularization Parameter Choice Technique for the Tikhonov Method

VT Scan: Towards an Efficient Pipeline from Computed Tomography Images to Ventricular Tachycardia Ablation

Spatially Coherent Activation Maps for Electrocardiographic Imaging