Isabelle DUPIN

Group leader (Interdisciplinary approaches for COPD understanding)

Parcours professionnel

2023 – 2028 Chaire Junior Fondamentale (poste de 5 ans), Institut Universitaire de France (IUF)

Depuis 2021 Professeure de Physiologie, CRCTB, INSERM U1045, Université de Bordeaux

2014 – 2021 Maître de conférences, CRCTB, INSERM U1045, Université de Bordeaux

2013 – 2014 Assistante hospitalo-universitaire, CRCTB, INSERM U1045, Université de Bordeaux

2010 – 2013 Chercheuse post-doctorale, Institut Interdisciplinaire de Neurosciences, UMR 5297, Université de Bordeaux

Financements

ERC Consolidator grant (2025-30, KINTSUGI project)

Chaire Junior Fondamentale IUF (2023-2028)

ANR Jeunes Chercheurs– Jeunes Chercheuses (2022-25, BRONCHIOLE project)

AAP ESR 2022 Région Nouvelle Aquitaine (2022)

Fondation Bordeaux Université-Fonds pour les Maladies Chroniques (2020)

Fondation Bordeaux Université-Fonds pour les Maladies Chroniques (2017)

Brevets

Berger P, Dupin I, Girodet PO. New compositions and methods of treating and/or preventing Chronic Obstructive Pulmonary Disease. Brevet déposé le 28/01/2015 (15152886.6), délivré par l’Office Européen des Brevets le 09/10/2019 sous le numéro EP 3050574.

Berger P, Bismuth K, Dupin I, Girodet PO, James C, Prevel R, Rattenbach R. New compositions and methods of treating COVID-19 disease. Brevet déposé le 07/05/2020 sous le numéro EP20173595.8. Licensié.

Membres

Isabelle DUPIN

Parcours professionnel

Financements

Brevets

Publications 29

Understanding and manipulating morphogenetic processes to generate in vitro models of airways

A novelin vitrotubular model to recapitulate features of distal airways: the bronchioid

Innovative three-dimensional models for understanding mechanisms underlying lung diseases: powerful tools for translational research

CXCR4 blockade alleviates pulmonary and cardiac outcomes in young COPD

Probabilistic cellular automata modelling of intercellular interactions in airways: complex pattern formation in patients with chronic obstructive pulmonary disease

Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epithelium

Première année de fonctionnement du parcours accès spécifique santé (PASS) de l’Université de Bordeaux : caractérisation et identification des facteurs de réussite pour la validation du PASS et l’entrée dans la filière médecine

Unravelling the effects of omalizumab on fibrocytes

Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling

Determination of reliable lung function parameters in intubated mice

Chemokines in COPD: From Implication to Therapeutic Use

Fibrocyte accumulation in the airway walls of COPD patients

Fibrocytes in Asthma and COPD: Variations on the Same Theme

Reply

Bronchial Smooth Muscle Remodeling in Nonsevere Asthma

Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients

Blood fibrocytes are recruited during acute exacerbations of chronic obstructive pulmonary disease through a CXCR4-dependent pathway.

The critical role of bronchial smooth muscle remodeling in non-severe asthma

Recruitment of blood fibrocytes during acute exacerbations of chronic obstructive pulmonary disease through a CXCR4 dependent pathway

p53 dysfunction increased mitochondrial biogenesis and bronchial smooth muscle cell proliferation in asthma

Calcium channel blocker reduces airway remodeling in severe asthma. A proof-of-concept study.

Adhesive Micropatterns to Study Intermediate Filament Function in Nuclear Positioning

House Dust Mites Induce Proliferation of Severe Asthmatic Smooth Muscle Cells via an Epithelium-Dependent Pathway

Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons

Investigating Axonal Guidance with Microdevice-Based Approaches

Amplification and Temporal Filtering during Gradient Sensing by Nerve Growth Cones Probed with a Microfluidic Assay

Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleus

Nuclear positioning: Mechanisms and functions

Classical cadherins control nucleus and centrosome position and cell polarity

Équipe

Remodelage bronchique