David BENOIST

Maitre de Conférences

Parcours professionnel

2025-now: Head of the Pathophysiology Department, Electrophysiology and Heart Modeling Institute (IHU Liryc), Bordeaux
2021-now: Head of teaching for the international MSc “Electromechanical Heart Diseases”, University of Bordeaux
2018-now: Associate Professor, Inserm U1045 CRCTB, IHU Liryc, University of Bordeaux.
2017-2018: Liryc research associate, Inserm U1045 CRCTB, IHU Liryc, University of Bordeaux.
2011-2017: Post-doctoral researcher, Inserm U1045 CRCTB, IHU Liryc, University of Bordeaux.
2007-2011: PhD student, Institute of Membrane and Systems Biology, University of Leeds (UK).

Financements

• Interdisciplinary and exploratory research grant from the University of Bordeaux (2025-2027): Identifiying pathogenic auto-immunity in cardiac arrhythmias. Co-PI : 78k€
• Project grant from Fédération Française de Cardiologie (2023-2025): Role of TREK-1 in right ventricular mechano-electric coupling and arrhythmogenicity. PI: 50k€.
• ANR Collaborative research project (2023-2027): Ventricular scar-mediated arrhythmogenesis. Co-PI: 118k€
• IHU Liryc 2021 internal call for collaborative translational research: Characterization of the right ventricular electrophysiological remodelling in rats with a BMPR2 mutation and pulmonary hypertension. 2021-2022. Co-PI : 30 k€.
• ANR young investigator research grant: Mechano-electric coupling in the healthy and pressure-overloaded right ventricular outflow tract. 2019-2023. PI : 298k€

Membres

David BENOIST

Parcours professionnel

Financements

Publications 20

AI-based identification of cardiac Purkinje fiber cells isolated from whole adult sheep hearts

Thrombosis in the Coronary Microvasculature Impairs Cardiac Relaxation and Induces Diastolic Dysfunction

Distinct Electrogram Features and Ventricular Arrhythmia Induction Modes Between Repolarization and Conduction Heterogeneities

OP2113, a new drug for chronic hypoxia-induced pulmonary hypertension treatment in rat.

Pathophysiological Roles of the TRPV4 Channel in the Heart

Pathophysiological Roles of TRPV4 Channel in the Heart

Cardiac structure discontinuities revealed by ex-vivo microstructural characterization. A focus on the basal inferoseptal left ventricle region

Functional Epicardial Conduction Disturbances Due to a SCN5A Variant Associated With Brugada Syndrome

Characterization of Experimentally Observed Complex Interplay between Pulse Duration, Electrical Field Strength, and Cell Orientation on Electroporation Outcome Using a Time-Dependent Nonlinear Numerical Model

Reversible and Irreversible Effects of Electroporation on Contractility and Calcium Homeostasis in Isolated Cardiac Ventricular Myocytes

Spiky: An ImageJ Plugin for Data Analysis of Functional Cardiac and Cardiomyocyte Studies.

A computational model of pig ventricular cardiomyocyte electrophysiology and calcium handling: Translation from pig to human electrophysiology

Beta1-adrenoceptor antagonist, metoprolol attenuates cardiac myocyte Ca2+ handling dysfunction in rats with pulmonary artery hypertension

Unexpected Internalization of a Pulmonary Artery Band in a Porcine Model of Tetralogy of Fallot

Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension

Lipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology

Microtubule proliferation in right ventricular myocytes of rats with monocrotaline-induced pulmonary hypertension

Regional skeletal muscle remodeling and mitochondrial dysfunction in right ventricular heart failure

Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current

Inhomogeneity in the response to mechanical stimulation: Cardiac muscle function and gene expression

Équipe

Electrophysiologie cardiaque