Roger MARTHAN

Professeur d’université-Praticien hospitalier

Parcours professionnel

Depuis 1993 : Professeur de Physiologie – Praticien Hospitalier
1998-2010 : Directeur de l’Équipe Mixte Inserm – Université Bordeaux 2 (EMI n° 9937) recréée (E 356) en 2003 et en 2006 en mono-équipe U 885
2006-2010 : Directeur IFR n° 4 « Cœur Poumons Vaisseaux Thrombose »
2006-2016 : Directeur de l’École Doctorale Sciences de la Vie et de la Santé de l’Université de Bordeaux
2008-2013 : Président du Comité de la Recherche Biomédicale et en Santé Publique du CHU de Bordeaux
2010-2023 : Vice-président Recherche du Directoire du CHU de Bordeaux
2011-2021 : Directeur de l’unité Inserm pluri-équipes « Centre de recherche Cardio-Thoracique de Bordeaux »
2016-2025 : Directeur du Collège des Écoles Doctorales de l’Université de Bordeaux

Financements

Inserm
Conseil Régional d’Aquitaine
ANR
FRM
Ministère de l’Environnement

Publications 268

avril 2025 American Journal of Respiratory Cell and Molecular Biology

CXCR4 Blockade Alleviates Pulmonary and Cardiac Outcomes in Early COPD

Auteurs : Isabelle Dupin, Pauline Henrot, Elise Maurat, Reshed Abohalaka, Sébastien Chaigne, Dounia El Hamrani, Edmée Eyraud, Renaud Prevel, Pauline Esteves, Marilyne Campagnac, Marielle Dubreuil, Guillaume Cardouat, Clément Bouchet, Olga Ousova, Jean-William Dupuy, Thomas Trian, Matthieu Thumerel, Hugues Begueret, Pierre-Olivier Girodet, Roger Marthan, Maeva Zysman, Véronique Freund-Michel, Patrick Berger
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avril 2025 iScience

Bronchial smooth muscle extracellular vesicles interfere with bronchial epithelium metabolism and function in asthma

Auteurs : Celle E, Chahin A, Beaufils F, Cardouat G, Eyraud E, Bouchet C, Campagnac M, Ousova O, Begueret H, Thumerel M, Dubois R, Dupuy J, Leste-Lasserre T, Esteves P
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mars 2025 Biomedicine & Pharmacotherapy

Celastrol has beneficial effects on pulmonary hypertension associated with bronchopulmonary dysplasia: Preclinical study outcomes

Auteurs : Claire-Marie Pilard, Guillaume Cardouat, Isabel Gauthereau, Laure Gassiat, Mathilde Dubois, Paul Robillard, Fanny Sauvestre, Fanny Pelluard, Sophie Berenguer, Melie Sarreau, Stéphane Claverol, Caroline Tokarski, Loïc Sentilhes, Frederic Coatleven, Marie Vincienne, Roger Marthan, Eric Dumas-de-la-roque, Patrick Berger, Mark K. Friedberg, Laurent Renesme, Véronique Freund-Michel, Christelle Guibert
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avril 2024 Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity.

Auteurs : Cardouat G, Douard M, Bouchet C, Roubenne L, Kmecová Z, Esteves P, Brette F, Guignabert C, Tu L, Campagnac M, Robillard P, Coste F, Delcambre F, Thumerel M, Begueret H, Maurac A, Belaroussi Y, Klimas J, Ducret T, Quignard JF, Vacher P, Baudrimont I, Marthan R, Berger P, Guibert C, Freund-Michel V
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juillet 2023 British journal of pharmacology

OP2113, a new drug for chronic hypoxia-induced pulmonary hypertension treatment in rat.

Auteurs : Roubenne L, Laisné M, Benoist D, Campagnac M, Prunet B, Pasdois P, Cardouat G, Ducret T, Quignard JF, Vacher P, Baudrimont I, Marthan R, Berger P, Guibert C
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novembre 2022 European journal of nuclear medicine and molecular imaging

On the factors affecting the liver SUV in [18F]FDG PET/CT imaging.

Auteurs : Laffon E, de Clermont H, Marthan R
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octobre 2022 Cancer biotherapy & radiopharmaceuticals

64Cu-/177Lu-Cetuximab Theranostic Pair: May the Single 64Cu-Cetuximab Diagnostic Scan Be Acquired at Any Time After Injection?

Auteurs : Laffon E, Marthan R
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septembre 2022 Cells

Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism

Auteurs : Clément Bouchet, Guillaume Cardouat, Matthieu Douard, Florence Coste, Paul Robillard, Frédéric Delcambre, Thomas Ducret, Jean-François Quignard, Pierre Vacher, Isabelle Baudrimont, Roger Marthan, Patrick Berger, Christelle Guibert, Véronique Freund-Michel
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juillet 2022 Biomolecules

Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia

Auteurs : Solène Barbeau, Alexandre Joushomme, Yann Chappe, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Patrick Berger, Pierre Vacher, Yann Percherancier, Jean-François Quignard, Thomas Ducret
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juillet 2022 Journal of Allergy and Clinical Immunology

Rhinovirus infection of bronchial epithelium induces specific bronchial smooth muscle cell migration of severe asthmatic patients

Auteurs : Alexis Celle, Pauline Esteves, Guillaume Cardouat, Fabien Beaufils, Edmée Eyraud, Isabelle Dupin, Elise Maurat, Sabrina Lacomme, Olga Ousova, Hugues Begueret, Matthieu Thumerel, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger, Thomas Trian
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mai 2022 Cancer biotherapy & radiopharmaceuticals

Estimation of Cumulative Activity of 177Lu-Cetuximab from a Single Diagnostic 64Cu-Cetuximab Scan.

Auteurs : Laffon E, Marthan R
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mars 2022 Cell Reports

Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epithelium

Auteurs : Pauline Esteves, Benoit Allard, Alexis Celle, Isabelle Dupin, Elise Maurat, Olga Ousova, Matthieu Thumerel, Jean-William Dupuy, Thierry Leste-Lasserre, Roger Marthan, Pierre-Olivier Girodet, Thomas Trian, Patrick Berger
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février 2022 Revue des Maladies Respiratoires

Implication des canaux mécanosensibles Piezo1 et TRPV4 dans l’hypertension pulmonaire

Auteurs : S. Barbeau, T. Porto Ribeiro, G. Gilbert, G. Cardouat, I. Baudrimont, V. Freund-Michel, C. Guibert, R. Marthan, P. Vacher, J.-F. Quignard, T. Ducret
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janvier 2022 Frontiers in Pharmacology

Muscarinic receptor M3 activation promotes fibrocytes contraction

Auteurs : Henrot, P., Eyraud, E., Maurat, E., Point, S., Cardouat, G., Quignard, J.-F., Esteves, P., Trian, T., Girodet, P.-O., Marthan, R., Zysman, M., Berger, P., Dupin, I.
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janvier 2022 Nanotoxicology

NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption.

Auteurs : Germande O, Baudrimont M, Beaufils F, Freund-Michel V, Ducret T, Quignard JF, Errera MH, Lacomme S, Gontier E, Mornet S, Bejko M, Muller B, Baudrimont I
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janvier 2022 bioRxiv

Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

Auteurs : Eyraud, E., Maurat, E., Sac-Epée, J.-M., Henrot, P., Zysman, M., Esteves, P., Trian, T., Bégueret, H., Girodet, P.-O., Thumerel, M., Hustache-Castaing, R., Marthan, R., Levet, F., Vallois, P., Contin-Bordes, C., Berger, P., Dupin, I.
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décembre 2021 European Respiratory Journal

Circulating fibrocytes as a new tool to predict lung cancer progression after surgery?

Auteurs : Pauline Henrot, Fabien Beaufils, Matthieu Thumerel, Edmée Eyraud, Augustin Boudoussier, Hugues Begueret, Elise Maurat, Pierre-Olivier Girodet, Roger Marthan, Patrick Berger, Isabelle Dupin, Maéva Zysman
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septembre 2021 Biomolecules

Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension

Auteurs : Solène Barbeau, Guillaume Gilbert, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Pierre Vacher, Jean-François Quignard, Thomas Ducret
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septembre 2021 Cardiovascular toxicology

Effects of FW2 Nanoparticles Toxicity in a New In Vitro Pulmonary Vascular Cells Model Mimicking Endothelial Dysfunction.

Auteurs : Deweirdt J, Ducret T, Quignard JF, Freund-Michel V, Lacomme S, Gontier E, Muller B, Marthan R, Guibert C, Baudrimont I
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septembre 2021 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

On Semiquantitative Methods for Assessing Vascular 18F-FDG PET Activity in Large-Vessel Vasculitis.

Auteurs : Laffon E, Marthan R
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août 2021 EJNMMI research

An abbreviated therapy-dosimetric equation for the companion diagnostic/therapeutic [64/67Cu]Cu-SARTATE.

Auteurs : Laffon E, de Clermont H, Marthan R
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juin 2021 Radiology

Is There a Relevant Imaging Time for Optimal Quantitative 89Zr-DFO-Daratumumab PET Imaging?

Auteurs : Eric Laffon, Roger Marthan
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juin 2021 Cells

Hydrogen Sulfide Metabolism and Pulmonary Hypertension

Auteurs : Lukas Roubenne, Roger Marthan, Bruno Le Grand, Christelle Guibert
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avril 2021 The European respiratory journal

Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling.

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avril 2021 The Journal of allergy and clinical immunology

Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers.

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février 2021 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Specific and Nonspecific Uptake in Quantitative 89Zr-Immuno-PET.

Auteurs : Laffon E, Marthan R
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octobre 2020 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Automated segmentation of TMTV in DLBCL patients: what about method measurement uncertainty?

Auteurs : Laffon E, Marthan R
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août 2020 European journal of nuclear medicine and molecular imaging

Is Patlak y-intercept a relevant metrics?

Auteurs : Laffon E, Marthan R
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mai 2020 Archives of toxicology

In vitro study of carbon black nanoparticles on human pulmonary artery endothelial cells: effects on calcium signaling and mitochondrial alterations.

Auteurs : Deweirdt J, Quignard JF, Lacomme S, Gontier E, Mornet S, Savineau JP, Marthan R, Guibert C, Baudrimont I
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mai 2020 European journal of nuclear medicine and molecular imaging

SUR for mediastinal metastatic lymph node status in non-small-cell lung cancer patients.

Auteurs : Laffon E, Marthan R
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mai 2020 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Distribution Volume of [18F]BMS-986192 in NSCLC Patients.

Auteurs : Laffon E, Marthan R
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mars 2020 The European respiratory journal

Connexin-43 is a promising target for pulmonary hypertension due to hypoxaemic lung disease.

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janvier 2020 American journal of physiology. Lung cellular and molecular physiology

Bnip3 as a potential target to treat airway smooth muscle remodeling in asthma?

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janvier 2020 Haematologica

Prognostic value of 18F-FDG-PET in patients with mantle cell lymphoma: results from the LyMa-PET Project.

Auteurs : Laffon E, Marthan R
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janvier 2020 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

SUVmax-V for Assessing Treatment Response in 18F-FDG PET Imaging of Patient-Derived Tumor Xenografts Involving Triple-Negative Breast Cancer.

Auteurs : Laffon E, Marthan R
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janvier 2020 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

11C-(+)-PHNO Trapping Reversibility for Quantitative PET Imaging of β-Cell Mass in Patients with Type 1 Diabetes.

Auteurs : Laffon E, Marthan R
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novembre 2019 American journal of physiology. Lung cellular and molecular physiology

TRPV4 channel mediates adventitial fibroblast activation and adventitial remodeling in pulmonary hypertension.

Auteurs : Cussac LA, Cardouat G, Tiruchellvam Pillai N, Campagnac M, Robillard P, Montillaud A, Guibert C, Gailly P, Marthan R, Quignard JF, Savineau JP, Ducret T
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novembre 2019 Physiology & behavior

Modelling analysis of centroid curves of olfactory habituation in humans.

Auteurs : Laffon E, Hummel T, Marthan R, Sinding C
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octobre 2019 European journal of nuclear medicine and molecular imaging

Fitting of late dynamic [18F]MK6240 PET scans for in vivo tau quantification.

Auteurs : Laffon E, Buj S, de Clermont H, Marthan R
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septembre 2019 Respiratory research

Determination of reliable lung function parameters in intubated mice.

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septembre 2019 The European respiratory journal

Fibrocyte accumulation in the airway walls of COPD patients.

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août 2019 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Quantification of 18F-DCFPyL Uptake: TBR versus Patlak’s Analysis.

Auteurs : Laffon E, de Clermont-Gallerande H, Marthan R
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août 2019 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Reversibility of 68Ga-FAPI-2 trapping might prove an asset for PET quantitative imaging.

Auteurs : Laffon E, Marthan R
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juin 2019 American journal of respiratory cell and molecular biology

Stretch-activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries.

Auteurs : Lhomme A, Gilbert G, Pele T, Deweirdt J, Henrion D, Baudrimont I, Campagnac M, Marthan R, Guibert C, Ducret T, Savineau JP, Quignard JF
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mars 2019 EJNMMI research

Correction to: Comparison of three-parameter kinetic model analysis to standard Patlak’s analysis in 18F-FDG PET imaging of lung cancer patients.

Auteurs : Laffon E, Calcagni ML, Galli G, Giordano A, Capotosti A, Marthan R, Indovina L
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février 2019 International journal of chronic obstructive pulmonary disease

Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension.

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février 2019 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Relevance of Measurement Uncertainty for Quantitative Response Assessment of Breast Cancer Bone Metastases with 18F-Fluoride.

Auteurs : Laffon E, Marthan R
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octobre 2018

Fibrocyte accumulation in bronchi: a cellular hallmark of COPD

Auteurs : Isabelle Dupin, Matthieu Thumerel, Elise Maurat, Florence Coste, Hugues Begueret, Thomas Trian, Michel Montaudon, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger
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octobre 2018 Respiratory medicine

Clinical and economic burden of severe asthma: A French cohort study.

Auteurs : Nordon C, Grimaldi-Bensouda L, Pribil C, Nachbaur G, Amzal B, Thabut G, Marthan R, Aubier M, COBRA Study Group
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octobre 2018 European journal of nuclear medicine and molecular imaging

Performance of 18F-FDG PET/MRI and 18F-FDG PET/CT for T and N staging in patients with non-small-cell lung cancer.

Auteurs : Laffon E, Marthan R
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juillet 2018 Physiology (Bethesda, Md.)

ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension.

Auteurs : Rode B, Bailey MA, Marthan R, Beech DJ, Guibert C
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juillet 2018 European journal of nuclear medicine and molecular imaging

Could we avoid computing TMTV of DLBCL patients in routine practice?

Auteurs : Laffon E, Marthan R
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mai 2018 European journal of nuclear medicine and molecular imaging

Optimal method for measuring baseline metabolic tumor volume in DLBCL patients: are statistical agreements of SUV ≥2.5 satisfactory?

Auteurs : Laffon E, Marthan R
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avril 2018 European journal of nuclear medicine and molecular imaging

Should we assess repeatability of PET quantitative uptake measurements of each 18F-labelled tracer?

Auteurs : Laffon E, de Clermont H, Buj S, Marthan R
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mars 2018 Pediatric pulmonology

Montelukast reverses airway remodeling in actively sensitized young mice.

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mars 2018 EJNMMI research

Comparison of three-parameter kinetic model analysis to standard Patlak’s analysis in 18F-FDG PET imaging of lung cancer patients.

Auteurs : Laffon E, Calcagni ML, Galli G, Giordano A, Capotosti A, Marthan R, Indovina L
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février 2018 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

6″-18F-Fluoromaltotriose PET Evaluation in Escherichia Coli-Induced Myositis: Is There Uptake Saturation in Control?

Auteurs : Laffon E, Marthan R
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novembre 2017 European journal of nuclear medicine and molecular imaging

On the 18F-fluoride PET imaging quantification to predict 223Ra-dichloride treatment response.

Auteurs : Laffon E, de Clermont H, Marthan R, Paycha F
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octobre 2017 Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

A three-time-point method for assessing kinetic parameters of 64Cu-labeled Ramucirumab trapping in VEGFR-2 positive lung tumors.

Auteurs : Laffon E, Marthan R
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juillet 2017 Toxicology in vitro : an international journal published in association with BIBRA

Involvement of oxidative stress and calcium signaling in airborne particulate matter – induced damages in human pulmonary artery endothelial cells.

Auteurs : Deweirdt J, Quignard JF, Crobeddu B, Baeza-Squiban A, Sciare J, Courtois A, Lacomme S, Gontier E, Muller B, Savineau JP, Marthan R, Guibert C, Baudrimont I
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juin 2017 Nuclear medicine communications

Measurement uncertainty of lesion and reference mediastinum standardized uptake value in lung cancer.

Auteurs : Laffon E, Milpied N, Marthan R
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mai 2017 Radiology

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis: MR Imaging of Airway Mucus Contrasts as a Tool for Diagnosis.

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mai 2017 European journal of nuclear medicine and molecular imaging

FDG PET for therapy monitoring in Hodgkin’s and non-Hodgkin’s lymphomas: qPET versus rPET.

Auteurs : Laffon E, Marthan R
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avril 2017 Biochemical pharmacology

T-type voltage gated calcium channels are involved in endothelium-dependent relaxation of mice pulmonary artery.

Auteurs : Gilbert G, Courtois A, Dubois M, Cussac LA, Ducret T, Lory P, Marthan R, Savineau JP, Quignard JF
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mars 2017 Respiratory research

Chronic hypoxia aggravates monocrotaline-induced pulmonary arterial hypertension: a rodent relevant model to the human severe form of the disease.

Auteurs : Coste F, Guibert C, Magat J, Abell E, Vaillant F, Dubois M, Courtois A, Diolez P, Quesson B, Marthan R, Savineau JP, Muller B, Freund-Michel V
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février 2017 PloS one

Altered vasoreactivity in neonatal rats with pulmonary hypertension associated with bronchopulmonary dysplasia: Implication of both eNOS phosphorylation and calcium signaling.

Auteurs : Dumas de la Roque E, Smeralda G, Quignard JF, Freund-Michel V, Courtois A, Marthan R, Muller B, Guibert C, Dubois M
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février 2017 Frontiers in physiology

Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries.

Auteurs : Genet N, Billaud M, Rossignol R, Dubois M, Gillibert-Duplantier J, Isakson BE, Marthan R, Savineau JP, Guibert C
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janvier 2017 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Cumulated Activity Comparison of 64Cu-/177Lu-Labeled Anti-Epidermal Growth Factor Receptor Antibody in Esophageal Squamous Cell Carcinoma Model.

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décembre 2016 Toxicology

Calcium signalling induced by in vitro exposure to silicium dioxide nanoparticles in rat pulmonary artery smooth muscle cells.

Auteurs : Dubes V, Parpaite T, Ducret T, Quignard JF, Mornet S, Reinhardt N, Baudrimont I, Dubois M, Freund-Michel V, Marthan R, Muller B, Savineau JP, Courtois A
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décembre 2016 Journal of clinical oncology : official journal of the American Society of Clinical Oncology

On the Cutoff of Baseline Total Metabolic Tumor Volume in High-Tumor-Burden Follicular Lymphoma.

Auteurs : Laffon E, Marthan R
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décembre 2016 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Repeatability of Quantitative Whole-Body 18F-FDG PET/CT Uptake Measures in Patients with Non-Small Cell Lung Cancer: Dynamic Versus Test-Retest Design.

Auteurs : Laffon E, Marthan R
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septembre 2016 Clinical nuclear medicine

Early Assessment of Treatment Response in Takayasu Arteritis: An 18FDG PET Procedure.

Auteurs : Caubet O, Meunier V, Marthan R, Laffon E
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avril 2016 Thorax

CT evaluation of small pulmonary vessels area in patients with COPD with severe pulmonary hypertension.

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avril 2016 Pharmacology & therapeutics

Expression and role of connexin-based gap junctions in pulmonary inflammatory diseases.

Auteurs : Freund-Michel V, Muller B, Marthan R, Savineau JP, Guibert C
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mars 2016 American journal of respiratory and critical care medicine

Bronchial Smooth Muscle Remodeling in Nonsevere Asthma.

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mars 2016 American journal of physiology. Lung cellular and molecular physiology

Caveolae are involved in mechanotransduction during pulmonary hypertension.

Auteurs : Gilbert G, Ducret T, Savineau JP, Marthan R, Quignard JF
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janvier 2016 Toxicology in vitro : an international journal published in association with BIBRA

Involvement of Heme Oxygenase-1 in particulate matter-induced impairment of NO-dependent relaxation in rat intralobar pulmonary arteries.

Auteurs : Barrier M, Bégorre MA, Baudrimont I, Dubois M, Freund-Michel V, Marthan R, Savineau JP, Muller B, Courtois A
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janvier 2016 Ultrasound in medicine & biology

Vital Capacity Impairment due to Neuromuscular Disease and its Correlation with Diaphragmatic Ultrasound: A Preliminary Study.

Auteurs : Carrié C, Bonnardel E, Vally R, Revel P, Marthan R, Marthan R
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décembre 2015 The Journal of allergy and clinical immunology

Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients.

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décembre 2015 American journal of respiratory and critical care medicine

Excess Risk of Cancer from Computed Tomography Scan Is Small but Not So Low as to Be Incalculable.

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novembre 2015 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

SUVpeak Performance in Lung Cancer: Comparison to Average SUV from the 40 Hottest Voxels.

Auteurs : Laffon E, Burger IA, Lamare F, de Clermont H, Marthan R
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octobre 2015 The Journal of allergy and clinical immunology

Blood fibrocytes are recruited during acute exacerbations of chronic obstructive pulmonary disease through a CXCR4-dependent pathway.

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août 2015 American journal of respiratory and critical care medicine

Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension.

Auteurs : Freund-Michel V, Cardoso Dos Santos M, Guignabert C, Montani D, Phan C, Coste F, Tu L, Dubois M, Girerd B, Courtois A, Humbert M, Savineau JP, Muller B
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juin 2015 Annals of surgery

Total Lesion Glycolysis in Early-stage Non-small Cell Lung Cancer: Proposal for an Alternative Dimensionless Volume-based Parameter.

Auteurs : Laffon E, Marthan R
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mai 2015 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Simplified Methods for Quantification of 18F-Fluoromethylcholine Uptake: Is SUVAUC,PP Actually an SUV?

Auteurs : Laffon E, de Clermont H, Marthan R
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mai 2015 The Lancet. Oncology

PET-adapted salvage therapy for Hodgkin’s lymphoma.

Auteurs : Laffon E, Marthan R
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avril 2015 American Journal of Respiratory and Critical Care Medicine

Calcium channel blocker reduces airway remodeling in severe asthma. A proof-of-concept study.

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avril 2015 Nuclear medicine and biology

The total amount of uptake may affect the input function: a theoretic approach about 18F-FDG PET imaging.

Auteurs : Laffon E, Marthan R
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mars 2015 PloS one

An age-wise comparison of human airway smooth muscle proliferative capacity.

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mars 2015 American journal of respiratory and critical care medicine

House dust mites induce proliferation of severe asthmatic smooth muscle cells via an epithelium-dependent pathway.

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mars 2015 Pflugers Archiv : European journal of physiology

Effect of hypoxia on TRPV1 and TRPV4 channels in rat pulmonary arterial smooth muscle cells.

Auteurs : Parpaite T, Cardouat G, Mauroux M, Gillibert-Duplantier J, Robillard P, Quignard JF, Marthan R, Savineau JP, Ducret T
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février 2015 Journal of cell science

Human FAM154A (SAXO1) is a microtubule-stabilizing protein specific to cilia and related structures.

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février 2015 Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Quantitative positron emission tomography imaging for response assessment of [18F]fluorodeoxyglucose-avid lymphomas: should we report standard uptake value confidence limits?

Auteurs : Laffon E, Marthan R
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janvier 2015 American journal of respiratory and critical care medicine

Computed tomographic measurement of airway remodeling and emphysema in advanced chronic obstructive pulmonary disease. Correlation with pulmonary hypertension.

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décembre 2014 Medical physics

Comment on « Correction for FDG PET dose extravasations: Monte Carlo validation and quantitative evaluation of patient studies » [Med. Phys. 41, 052502 (2014)].

Auteurs : Buj S, Tendero K, Marthan R, Laffon E
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novembre 2014 Radiology

Prognostic value of mean standardized uptake value in patients with stage I non-small cell lung cancer treated with stereotactic body radiation therapy.

Auteurs : Laffon E, Marthan R
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octobre 2014 European journal of nuclear medicine and molecular imaging

Liver SUV versus stage in Hodgkin’s lymphoma: the total amount of uptake may play a role in the inverse relationship.

Auteurs : Laffon E, de Clermont H, Lamare F, Marthan R
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août 2014 European journal of nuclear medicine and molecular imaging

Interim FDG PET scans in lymphoma: SUV measurement error may impair qPET methodology.

Auteurs : Laffon E, Marthan R
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juillet 2014 Cardiovascular research

T-type calcium channels are involved in hypoxic pulmonary hypertension.

Auteurs : Chevalier M, Gilbert G, Roux E, Lory P, Marthan R, Savineau JP, Quignard JF
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juin 2014 Transplantation proceedings

Impact of donor-to-recipient weight ratio on survival after bilateral lung transplantation.

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juin 2014 Nuclear medicine and biology

Estimating the amount of FDG uptake in physiological tissues.

Auteurs : Laffon E, de Clermont H, Lamare F, Marthan R
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juin 2014 European radiology

Variability of average SUV from several hottest voxels is lower than that of SUVmax and SUVpeak.

Auteurs : Laffon E, Lamare F, de Clermont H, Burger IA, Marthan R
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mai 2014 The Journal of allergy and clinical immunology

Bronchi wall and lumen volumes to assess airway remodeling in asthma by using CT: an innovative method?

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avril 2014 Cardiovascular research

Stretch-induced Ca2+ signalling in vascular smooth muscle cells depends on Ca2+ store segregation.

Auteurs : Gilbert G, Ducret T, Marthan R, Savineau JP, Quignard JF
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février 2014 PloS one

Protease activated receptor-2 expression and function in asthmatic bronchial smooth muscle.

Auteurs :
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novembre 2013 PloS one

Biopterin metabolism and eNOS expression during hypoxic pulmonary hypertension in mice.

Auteurs : Dubois M, Delannoy E, Duluc L, Closs E, Li H, Toussaint C, Gadeau AP, Gödecke A, Freund-Michel V, Courtois A, Marthan R, Savineau JP, Muller B
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août 2013 Journal of nuclear medicine technology

Variability of total lesion glycolysis by 18F-FDG-positive tissue thresholding in lung cancer.

Auteurs : Laffon E, de Clermont H, Lamare F, Marthan R
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août 2013 Molecular imaging and biology

Dynamic changes of 18F-FDG uptake in normal lung: probing a predictive model analysis.

Auteurs : Laffon E, Marthan R
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juillet 2013 Journal of applied toxicology : JAT

Characterization of the components of urban particulate matter mediating impairment of nitric oxide-dependent relaxation in intrapulmonary arteries.

Auteurs : Courtois A, Prouillac C, Baudrimont I, Ohayon-Courtes C, Freund-Michel V, Dubois M, Lisbonne-Autissier M, Marthan R, Savineau JP, Muller B
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mai 2013 Pediatric research

Beneficial effect of dehydroepiandrosterone on pulmonary hypertension in a rodent model of pulmonary hypertension in infants.

Auteurs : Dumas de la Roque E, Quignard JF, Ducret T, Dahan D, Courtois A, Begueret H, Marthan R, Savineau JP
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avril 2013 EJNMMI research

Calculating an estimate of tissue integrated activity in 18F-FDG PET imaging using one SUV value.

Auteurs : Laffon E, Bardiès M, Barbet J, Marthan R
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janvier 2013 Therapeutic advances in respiratory disease

Reactive oxygen species as therapeutic targets in pulmonary hypertension.

Auteurs : Freund-Michel V, Guibert C, Dubois M, Courtois A, Marthan R, Savineau JP, Muller B
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décembre 2012 Biochemical pharmacology

Role of DHEA in cardiovascular diseases.

Auteurs : Savineau JP, Marthan R, Dumas de la Roque E
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novembre 2012 American journal of respiratory cell and molecular biology

Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model.

Auteurs :
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octobre 2012 PloS one

In vivo micro-CT assessment of airway remodeling in a flexible OVA-sensitized murine model of asthma.

Auteurs : Lederlin M, Ozier A, Dournes G, Ousova O, Girodet PO, Begueret H, Marthan R, Montaudon M, Laurent F, Berger P
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octobre 2012 European radiology

Variability of ¹⁸F-FDG-positive lung lesion volume by thresholding.

Auteurs : Laffon E, de Clermont H, Marthan R
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septembre 2012

Comments on Point:Counterpoint: Alterations in airway smooth muscle phenotype do/do not cause airway hyperresponsiveness in asthma.

Auteurs : Bosse Y, Vagula MC, Rawding RS, Pun M, Black JL, Burgess J, Oliver B, Berger P, Marthan R, Adner M
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septembre 2012 American journal of physiology. Lung cellular and molecular physiology

Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.

Auteurs : Dahan D, Ducret T, Quignard JF, Marthan R, Savineau JP, Estève E
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juillet 2012 Pflugers Archiv : European journal of physiology

Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells.

Auteurs : Martin E, Dahan D, Cardouat G, Gillibert-Duplantier J, Marthan R, Savineau JP, Ducret T
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juin 2012 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

18F-FDG uptake to assess eosinophilic inflammation in asthma: would SUV at late imaging be relevant?

Auteurs : Laffon E, Marthan R
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mai 2012 Pediatric pulmonology

Effect of high-frequency oscillation and percussion versus conventional ventilation in a piglet model of meconium aspiration.

Auteurs : Renesme L, Elleau C, Nolent P, Fayon M, Marthan R, Dumas De La Roque E
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avril 2012 The European respiratory journal

Dehydroepiandrosterone reverses chronic hypoxia/reoxygenation-induced right ventricular dysfunction in rats.

Auteurs : Dumas de La Roque E, Bellance N, Rossignol R, Begueret H, Billaud M, dos Santos P, Ducret T, Marthan R, Dahan D, Ramos-Barbón D, Amor-Carro Ó, Fayon M
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mars 2012 Biochemical pharmacology

Dehydroepiandrosterone (DHEA) inhibits voltage-gated T-type calcium channels.

Auteurs : Chevalier M, Gilbert G, Lory P, Marthan R, Quignard JF, Savineau JP
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janvier 2012 American journal of respiratory and critical care medicine

Role of YKL-40 in bronchial smooth muscle remodeling in asthma.

Auteurs :
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janvier 2012 Annales d'endocrinologie

Dehydroepiandrosterone (DHEA) improves pulmonary hypertension in chronic obstructive pulmonary disease (COPD): a pilot study.

Auteurs : Dumas de La Roque E, Savineau JP, Metivier AC, Billes MA, Kraemer JP, Doutreleau S, Jougon J, Marthan R, Moore N, Fayon M, Baulieu EÉ, Dromer C
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octobre 2011 Journal of vascular research

Development and characterization of an animal model of severe pulmonary arterial hypertension.

Auteurs : Morimatsu Y, Sakashita N, Komohara Y, Ohnishi K, Masuda H, Dahan D, Takeya M, Guibert C, Marthan R
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août 2011 Journal of nuclear medicine technology

Is liver SUV stable over time in ¹⁸F-FDG PET imaging?

Auteurs : Laffon E, Adhoute X, de Clermont H, Marthan R
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juillet 2011 European radiology

A method of adjusting SUV for injection-acquisition time differences in (18)F-FDG PET imaging.

Auteurs : Laffon E, de Clermont H, Marthan R
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avril 2011 Molecular imaging and biology

Feasibility of assessing [(18)F]FDG lung metabolism with late dynamic PET imaging.

Auteurs : Laffon E, de Clermont H, Vernejoux JM, Jougon J, Marthan R
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mars 2011

[Pathophysiology of asthma].

Auteurs : Ozier A, Bara I, Girodet PO, Marthan R, Berger P
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mars 2011 Revue des maladies respiratoires

[COPD and inflammation: Statement from a French expert group. How to treat inflammation?].

Auteurs : Roche N, Devillier P, Aguilaniu B, Escamilla R, Wallaert B, Burgel PR, Berger P, Brillet PY, Chambellan A, Chanez P, Chaouat A, Louis R, Mal H, Aubier M
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mars 2011 Respiratory research

Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension.

Auteurs : Billaud M, Dahan D, Marthan R, Savineau JP, Guibert C
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février 2011 Pharmacology & therapeutics

Airway remodeling in asthma: new mechanisms and potential for pharmacological intervention.

Auteurs : Girodet PO, Ozier A, Bara I, Tunon de Lara JM, Marthan R, Berger P
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février 2011 Respiratory medicine

Control maintenance can be predicted by exhaled NO monitoring in asthmatic patients.

Auteurs : Ozier A, Girodet PO, Bara I, Tunon de Lara JM, Marthan R, Berger P
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février 2011 Revue des maladies respiratoires

[COPD and inflammation: statement from a French expert group. Phenotypes related to inflammation].

Auteurs : Perez T, Mal H, Aguilaniu B, Brillet PY, Chaouat A, Louis R, Muir JF, Similowski T, Berger P, Burgel PR, Chambellan A, Chanez P, Devillier P, Roche N
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janvier 2011

The pivotal role of airway smooth muscle in asthma pathophysiology.

Auteurs : Ozier A, Allard B, Bara I, Girodet PO, Trian T, Marthan R, Berger P
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janvier 2011 EUROPEAN RESPIRATORY REVIEW

Beyond corticosteroids: future prospects in the management of inflammation in COPD

Auteurs :
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janvier 2011 Canadian journal of physiology and pharmacology

Chronic hypoxia-induced alterations in mitochondrial energy metabolism are not reversible in rat heart ventricles.

Auteurs : Nouette-Gaulain K, Biais M, Savineau JP, Marthan R, Mazat JP, Letellier T, Sztark F
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décembre 2010 Cancer biotherapy & radiopharmaceuticals

Kinetic model analysis for absorbed dose calculation applied to brain in [¹⁸F]-fluorodeoxyglucose positron emission tomography imaging.

Auteurs : Laffon E, Bardiès M, Barbet J, Marthan R
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novembre 2010 Revue des maladies respiratoires

[COPD and inflammation: statement from a French expert group: inflammation and remodelling mechanisms].

Auteurs : Aubier M, Marthan R, Berger P, Chambellan A, Chanez P, Aguilaniu B, Brillet PY, Burgel PR, Chaouat A, Devillier P, Escamilla R, Louis R, Mal H, Roche N
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octobre 2010 Cell calcium

Stretch-activated channels in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.

Auteurs : Ducret T, El Arrouchi J, Courtois A, Quignard JF, Marthan R, Savineau JP
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octobre 2010 NMR in biomedicine

Effect of chronic hypoxia on pulmonary artery blood velocity in rats as assessed by electrocardiography-triggered three-dimensional time-resolved MR angiography.

Auteurs : de La Roque ED, Thiaudière E, Ducret T, Marthan R, Franconi JM, Guibert C, Parzy E
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mars 2010 Toxicology and applied pharmacology

Effect of engineered nanoparticles on vasomotor responses in rat intrapulmonary artery.

Auteurs : Courtois A, Andujar P, Ladeiro Y, Ducret T, Rogerieux F, Lacroix G, Baudrimont I, Guibert C, Roux E, Canal-Raffin M, Brochard P, Marano F, Marthan R, Muller B
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février 2010 Allergy

Mast cell adhesion to bronchial smooth muscle in asthma specifically depends on CD51 and CD44 variant 6.

Auteurs :
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janvier 2010 EUROPEAN RESPIRATORY JOURNAL

Pathophysiology of bronchial smooth muscle remodelling in asthma

Auteurs :
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septembre 2009 Radiology

Bronchial measurements in patients with asthma: comparison of quantitative thin-section CT findings with those in healthy subjects and correlation with pathologic findings.

Auteurs : Montaudon M, Lederlin M, Reich S, Begueret H, Tunon-de-Lara JM, Marthan R, Berger P, Laurent F
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août 2009 European radiology

Airway remodeling in a mouse asthma model assessed by in-vivo respiratory-gated micro-computed tomography.

Auteurs : Lederlin M, Ozier A, Montaudon M, Begueret H, Ousova O, Marthan R, Berger P, Laurent F
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août 2009 Cardiovascular research

Hypoxia-induced hyperreactivity of pulmonary arteries: role of cyclooxygenase-2, isoprostanes, and thromboxane receptors.

Auteurs : Delannoy E, Courtois A, Freund-Michel V, Leblais V, Marthan R, Muller B
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juillet 2009 PloS one

Vascular smooth muscle modulates endothelial control of vasoreactivity via reactive oxygen species production through myoendothelial communications.

Auteurs : Billaud M, Marthan R, Savineau JP, Guibert C
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juin 2009 Nuclear medicine communications

Assessment of dual-time-point 18F-FDG-PET imaging for pulmonary lesions.

Auteurs :
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juin 2009 The European respiratory journal

Signalling pathways involved in the contractile response to 5-HT in the human pulmonary artery.

Auteurs : Rodat-Despoix L, Aires V, Ducret T, Marthan R, Savineau JP, Rousseau E, Guibert C
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mai 2009 Journal of nuclear medicine technology

Is the physical decay correction of the (18)F-FDG input function in dynamic PET imaging justified?

Auteurs : Laffon E, Barret O, Marthan R, Ducassou D
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février 2009 Journal of magnetic resonance imaging : JMRI

Transit-time method to demonstrate whether or not an impedance matching occurs at the pulmonary junction.

Auteurs : Laffon E, Laurent F, Ducassou D, Marthan R
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janvier 2009 European radiology

Bronchial morphometry in smokers: comparison with healthy subjects by using 3D CT.

Auteurs : Montaudon M, Berger P, Lederlin M, Marthan R, Tunon-de-Lara JM, Laurent F
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novembre 2008 Journal of nuclear medicine technology

The effect of renal failure on 18F-FDG uptake: a theoretic assessment.

Auteurs : Laffon E, Cazeau AL, Monet A, de Clermont H, Fernandez P, Marthan R, Ducassou D
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mai 2008 Environmental health perspectives

Impairment of NO-dependent relaxation in intralobar pulmonary arteries: comparison of urban particulate matter and manufactured nanoparticles.

Auteurs : Courtois A, Andujar P, Ladeiro Y, Baudrimont I, Delannoy E, Leblais V, Begueret H, Galland MA, Brochard P, Marano F, Marthan R, Muller B
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décembre 2007 The Journal of experimental medicine

Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma.

Auteurs :
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novembre 2007 Journal of vascular research

Heterogeneity in 5-HT-induced contractile and proliferative responses in rat pulmonary arterial bed.

Auteurs : Rodat-Despoix L, Crevel H, Marthan R, Savineau JP, Guibert C
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octobre 2007 Journal of anatomy

Assessment of bronchial wall thickness and lumen diameter in human adults using multi-detector computed tomography: comparison with theoretical models.

Auteurs : Montaudon M, Desbarats P, Berger P, de Dietrich G, Marthan R, Laurent F
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juillet 2007 Cell calcium

Serotonin-induced activation of TRPV4-like current in rat intrapulmonary arterial smooth muscle cells.

Auteurs : Ducret T, Guibert C, Marthan R, Savineau JP
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février 2007 Allergy

Omalizumab decreases nonspecific airway hyperresponsiveness in vitro.

Auteurs : Berger P, Scotto-Gomez E, Molimard M, Marthan R, Le Gros V, Tunon-de-Lara JM
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janvier 2007 Current pharmaceutical design

Modulation of ion channels in pulmonary arterial hypertension.

Auteurs : Guibert C, Marthan R, Savineau JP
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mai 2004 American journal of physiology. Lung cellular and molecular physiology

Store-operated calcium entry and intracellular calcium release channels in airway smooth muscle.

Auteurs : Marthan R
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janvier 2004 American journal of physiology. Lung cellular and molecular physiology

5-HT induces an arachidonic acid-sensitive calcium influx in rat small intrapulmonary artery.

Auteurs : Guibert C, Marthan R, Savineau JP
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janvier 2004 The Journal of pharmacology and experimental therapeutics

Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery.

Auteurs : Leblais V, Pourageaud F, Ivorra MD, Guibert C, Marthan R, Muller B
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novembre 2003

Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis.

Auteurs : Berger P, Girodet PO, Begueret H, Ousova O, Perng DW, Marthan R, Walls AF, Tunon de Lara JM
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novembre 2003 European radiology

Quantitative MRI comparison of systemic hemodynamics in Mustard/Senning repaired patients and healthy volunteers at rest.

Auteurs : Laffon E, Jimenez M, Latrabe V, Ducassou D, Choussat A, Marthan R, Laurent F
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novembre 2003 Revue des maladies respiratoires

[Exercise testing in respiratory medicine]

Auteurs : Marthan R
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septembre 2003 Muscle & nerve

A prospective evaluation of phrenic nerve conduction in multifocal motor neuropathy and chronic inflammatory demyelinating polyneuropathy.

Auteurs : Macia F, Le Masson G, Rouanet-Larriviere M, Habonimana D, Ferrer X, Marthan R, Lagueny A
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août 2003 Journal of applied physiology (Bethesda, Md. : 1985)

A computed method for noninvasive MRI assessment of pulmonary arterial hypertension.

Auteurs : Laffon E, Vallet C, Bernard V, Montaudon M, Ducassou D, Laurent F, Marthan R
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août 2003 Physiological measurement

MRI quantification of the role of the reflected pressure wave on coronary and ascending aortic blood flow.

Auteurs : Laffon E, Galy-Lacour C, Laurent F, Ducassou D, Marthan R
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juillet 2003 Proceedings of the National Academy of Sciences of the United States of America

Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension.

Auteurs : Bonnet S, Dumas-de-La-Roque E, Bégueret H, Marthan R, Fayon M, Dos Santos P, Savineau JP, Baulieu EE
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juin 2003 Pediatric pulmonology

Montelukast does not protect against hyperoxia-induced inhibition of alveolarization in newborn rats.

Auteurs : Jouvencel P, Fayon M, Choukroun ML, Carles D, Montaudon D, Dumas E, Begueret H, Marthan R
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juin 2003 British journal of pharmacology

Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery.

Auteurs : Pauvert O, Lugnier C, Keravis T, Marthan R, Rousseau E, Savineau JP
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mai 2003 Radiology

Structure and function of small airways in smokers: relationship between air trapping at CT and airway inflammation.

Auteurs : Berger P, Laurent F, Begueret H, Perot V, Rouiller R, Raherison C, Molimard M, Marthan R, Tunon-de-Lara JM
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avril 2003 The Journal of biological chemistry

Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation.

Auteurs : Taillé C, Almolki A, Benhamed M, Zedda C, Mégret J, Berger P, Lesèche G, Fadel E, Yamaguchi T, Marthan R, Aubier M, Boczkowski J
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avril 2003 Anesthesia and analgesia

The effects of propofol and etomidate on airway contractility in chronically hypoxic rats.

Auteurs : Ouédraogo N, Marthan R, Roux E
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décembre 2002

[The pathophysiological role of smooth muscle cells in bronchial inflammation]

Auteurs : Berger P, Marthan R, Tunon de Lara JM
Lire la suite
décembre 2002 Anesthesiology

Effects of bupivacaine on mitochondrial energy metabolism in heart of rats following exposure to chronic hypoxia.

Auteurs : Nouette-Gaulain K, Forestier F, Malgat M, Marthan R, Mazat JP, Sztark F
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septembre 2002 American journal of physiology. Lung cellular and molecular physiology

Combined effect of chronic hypoxia and in vitro exposure to gas pollutants on airway reactivity.

Auteurs : Roux E, Duvert M, Marthan R
Lire la suite
juillet 2002 Allergy

Passive sensitization of human airways induces mast cell degranulation and release of tryptase.

Auteurs : Berger P, N'guyen C, Buckley M, Scotto-Gomez E, Marthan R, Tunon-de-Lara JM
Lire la suite
juin 2002 Pediatric pulmonology

Differential effect of dexamethasone and hydrocortisone on alveolar growth in rat pups.

Auteurs : Fayon M, Jouvencel P, Carles D, Choukroun ML, Marthan R
Lire la suite
mai 2002 Biochemical pharmacology

Characterisation of cyclic nucleotide phosphodiesterase isoforms in the media layer of the main pulmonary artery.

Auteurs : Pauvert O, Salvail D, Rousseau E, Lugnier C, Marthan R, Savineau JP
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mars 2002 Cardiovascular research

Reversal of chronic hypoxia-induced alterations in pulmonary artery smooth muscle electromechanical coupling upon air breathing.

Auteurs : Bonnet S, Dubuis E, Vandier C, Martin S, Marthan R, Savineau JP
Lire la suite
février 2002 Pediatric pulmonology

Pharmacologically induced relaxation of tracheal smooth muscle is increased in hyperoxia-exposed 15-day-old rats.

Auteurs : Fayon MJ, Denis D, Molimard M, Berger P, Choukroun ML, Demarquez JL, Marthan R, Clevel H, Lachaud JL, Martinez B, Téchoueyres P
Lire la suite
janvier 2002 Cell biology and toxicology

In vitro effect of air pollutants on human bronchi.

Auteurs : Roux E, Ouedraogo N, Hyvelin JM, Savineau JP, Marthan R
Lire la suite
septembre 2001

Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells.

Auteurs : Berger P, Perng DW, Thabrew H, Compton SJ, Cairns JA, McEuen AR, Marthan R, Tunon De Lara JM, Walls AF
Lire la suite
août 2001

Selected contribution: tryptase-induced PAR-2-mediated Ca(2+) signaling in human airway smooth muscle cells.

Auteurs : Berger P, Tunon-De-Lara JM, Savineau JP, Marthan R
Lire la suite
juillet 2001 American journal of physiology. Lung cellular and molecular physiology

Effect of chronic hypoxia on agonist-induced tone and calcium signaling in rat pulmonary artery.

Auteurs : Bonnet S, Belus A, Hyvelin JM, Roux E, Marthan R, Savineau JP
Lire la suite
juillet 2001 American journal of physiology. Lung cellular and molecular physiology

Chronic hypoxia-induced spontaneous and rhythmic contractions in the rat main pulmonary artery.

Auteurs : Bonnet S, Hyvelin JM, Bonnet P, Marthan R, Savineau JP
Lire la suite
juin 2001 Journal of applied physiology (Bethesda, Md. : 1985)

Noninvasive assessment of pulmonary arterial hypertension by MR phase-mapping method.

Auteurs : Laffon E, Laurent F, Bernard V, De Boucaud L, Ducassou D, Marthan R
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février 2001 Journal of applied physiology (Bethesda, Md. : 1985)

Selected contribution: effect of the aldehyde acrolein on acetylcholine-induced membrane current in airway smooth muscle cells.

Auteurs : Hyvelin JM, Savineau JP, Marthan R
Lire la suite
février 2001 Journal of applied physiology (Bethesda, Md. : 1985)

Tuning of pulmonary arterial circulation evidenced by MR phase mapping in healthy volunteers.

Auteurs : Laffon E, Bernard V, Montaudon M, Marthan R, Barat JL, Laurent F
Lire la suite
janvier 2001 PEDIATRIC RESEARCH

Prolonged moderate hyperoxia induces hyperresponsiveness and airway inflammation in newborn rats

Auteurs :
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novembre 2000 British journal of pharmacology

Role of EDHF in the vasodilatory effect of loop diuretics in guinea-pig mesenteric resistance arteries.

Auteurs : Pourageaud F, Bappel-Gozalbes C, Marthan R, Freslon JL
Lire la suite
août 2000 American journal of respiratory and critical care medicine

Human isolated bronchial smooth muscle contains functional ryanodine/caffeine-sensitive Ca-release channels.

Auteurs : Hyvelin JM, Martin C, Roux E, Marthan R, Savineau JP
Lire la suite
juillet 2000 Fundamental & clinical pharmacology

Interaction of extracellular albumin and intravenous anaesthetics, etomidate and propofol, on calcium signalling in rat airway smooth muscle cells.

Auteurs : Belouchi NE, Roux E, Savineau JP, Marthan R
Lire la suite
juin 2000 Cell calcium

NO-induced modulation of calcium-oscillations in pulmonary vascular smooth muscle.

Auteurs : Pauvert O, Marthan R, Savineau J
Lire la suite
juin 2000 Revue des maladies respiratoires

[Genetic polymorphism and asthma]

Auteurs : Molimard M, Marthan R
Lire la suite
juin 2000 Revue des maladies respiratoires

[Special characteristics of bronchial smooth muscle cells]

Auteurs : Marthan R, Molimard M
Lire la suite
juin 2000 Revue des maladies respiratoires

[In vitro techniques for the study of muscle contractility]

Auteurs : Advenier C, Naline E, Molimard M, Marthan R
Lire la suite
avril 2000 Toxicology and applied pharmacology

Cellular mechanisms of acrolein-induced alteration in calcium signaling in airway smooth muscle.

Auteurs : Hyvelin JM, Roux E, Prévost MC, Savineau JP, Marthan R
Lire la suite
février 2000 News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society

Cytosolic Calcium Oscillations in Smooth Muscle Cells.

Auteurs : Savineau JP, Marthan R
Lire la suite
janvier 2000 European radiology

Functional significance of air trapping detected in moderate asthma.

Auteurs : Laurent F, Latrabe V, Raherison C, Marthan R, Tunon-de-Lara JM
Lire la suite
janvier 2000 Life sciences

Cellular mechanisms involved in iso-osmotic high K+ solutions-induced contraction of the estrogen-primed rat myometrium.

Auteurs : Trujillo MM, Ausina P, Savineau JP, Marthan R, Strippoli G, Advenier C, Pinto FM, Candenas ML
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août 1999 The American journal of physiology

Pregnant rat myometrial cells show heterogeneous ryanodine- and caffeine-sensitive calcium stores.

Auteurs : Martin C, Hyvelin JM, Chapman KE, Marthan R, Ashley RH, Savineau JP
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août 1999 American journal of respiratory and critical care medicine

Human isolated airway contraction: interaction between air pollutants and passive sensitization.

Auteurs : Roux E, Hyvelin JM, Savineau JP, Marthan R
Lire la suite
juillet 1999 The European respiratory journal

Effect of chronic hypoxia on calcium signalling in airway smooth muscle cells.

Auteurs : Belouchi NE, Roux E, Savineau JP, Marthan R
Lire la suite
juin 1999

Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi.

Auteurs : Berger P, Compton SJ, Molimard M, Walls AF, N'Guyen C, Marthan R, Tunon-De-Lara JM
Lire la suite
avril 1999 AJR. American journal of roentgenology

Pneumothoraces and chest tube placement after CT-guided transthoracic lung biopsy using a coaxial technique: incidence and risk factors.

Auteurs : Laurent F, Michel P, Latrabe V, Tunon de Lara M, Marthan R
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janvier 1999 EUROPEAN RESPIRATORY JOURNAL

Assessment of bronchial inflammation using an automated cell recognition system based on colour analysis

Auteurs :
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janvier 1999 Therapie

[Electrophysiology and calcium signalling in human bronchial smooth muscle]

Auteurs : Marthan R, Hyvelin JM, Roux E, Savineau JP
Lire la suite
janvier 1999 Bulletin de l'Academie nationale de medecine

[Cellular pathophysiologic effects of various air pollutants on the airways]

Auteurs : Marthan R
Lire la suite
septembre 1998 Electromyography and clinical neurophysiology

Study of central and peripheral conductions to the diaphragm in 22 patients with definite multiple sclerosis.

Auteurs : Lagueny A, Arnaud A, Le Masson G, Burbaud P, Deliac P, Marthan R
Lire la suite
septembre 1998 American journal of respiratory cell and molecular biology

Calcium signaling in airway smooth muscle cells is altered by in vitro exposure to the aldehyde acrolein.

Auteurs : Roux E, Hyvelin JM, Savineau JP, Marthan R
Lire la suite
septembre 1998 General pharmacology

Muscarinic stimulation of airway smooth muscle cells.

Auteurs : Roux E, Molimard M, Savineau JP, Marthan R
Lire la suite
août 1998 The American journal of physiology

Cellular mechanisms and role of endothelin-1-induced calcium oscillations in pulmonary arterial myocytes.

Auteurs : Hyvelin JM, Guibert C, Marthan R, Savineau JP
Lire la suite
juin 1998 Revue des maladies respiratoires

[Leukotrienes and airway smooth muscle]

Auteurs : Marthan R
Lire la suite
février 1998 American journal of respiratory and critical care medicine

Immunoglobulin E-induced passive sensitization of human airways: an immunohistochemical study.

Auteurs : Berger P, Walls AF, Marthan R, Tunon-de-Lara JM
Lire la suite
février 1998 Anesthesiology

Effects of intravenous anesthetics on normal and passively sensitized human isolated airway smooth muscle.

Auteurs : Ouedraogo N, Roux E, Forestier F, Rossetti M, Savineau JP, Marthan R
Lire la suite
janvier 1998 Revue de pneumologie clinique

[Genetic polymorphism of adrenergic beta 2 receptors]

Auteurs : Marthan R
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juin 1997 Cell calcium

Oscillatory Cl- current induced by angiotensin II in rat pulmonary arterial myocytes: Ca2+ dependence and physiological implication.

Auteurs : Guibert C, Marthan R, Savineau JP
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avril 1997 British journal of pharmacology

[Ca2+]i oscillations induced by muscarinic stimulation in airway smooth muscle cells: receptor subtypes and correlation with the mechanical activity.

Auteurs : Roux E, Guibert C, Savineau JP, Marthan R
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janvier 1997 Fundamental & clinical pharmacology

Modulation of the calcium sensitivity of the smooth muscle contractile apparatus: molecular mechanisms, pharmacological and pathophysiological implications.

Auteurs : Savineau JP, Marthan R
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décembre 1996 Cell biology and toxicology

Human bronchial smooth muscle responsiveness after in vitro exposure to oxidizing pollutants.

Auteurs : Marthan R, Roux E, Savineau JP
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décembre 1996 The European respiratory journal

Pulmonary gas exchange in elderly subjects.

Auteurs : Guénard H, Marthan R
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octobre 1996 The American journal of physiology

Human and rat airway smooth muscle responsiveness after ozone exposure in vitro.

Auteurs : Roux E, Guibert C, Crevel H, Savineau JP, Marthan R
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septembre 1996 The American journal of physiology

Effect of extracellular ATP on cytosolic Ca2+ concentration in rat pulmonary artery myocytes.

Auteurs : Guibert C, Pacaud P, Loirand G, Marthan R, Savineau JP
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juin 1996 Pulmonary pharmacology

Effect of modulators of tyrosine kinase activity on agonist-induced contraction in the rat pulmonary vascular smooth muscle.

Auteurs : Savineau JP, Gonzalez De La Fuente P, Marthan R
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mai 1996 The European respiratory journal

Airway circulation in health and disease.

Auteurs : Lockhart A, Marthan R, Charan N, Paré P
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avril 1996 The American journal of physiology

Angiotensin II-induced Ca(2+)-oscillations in vascular myocytes from the rat pulmonary artery.

Auteurs : Guibert C, Marthan R, Savineau JP
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février 1996 Transplantation proceedings

Improvement of brain-dead lung assessment based on the mechanical properties of the respiratory system.

Auteurs : Labrousse L, Sztark F, Kays C, Thicoïpe M, Lassié P, Couraud L, Marthan R
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novembre 1995 The European respiratory journal

IgE-induced passive sensitization of human isolated bronchi and lung mast cells.

Auteurs : Tunon de Lara JM, Okayama Y, Savineau JP, Marthan R
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juin 1995 The American journal of physiology

Role of protein kinase C in nonsensitized and passively sensitized human isolated bronchial smooth muscle.

Auteurs : Rossetti M, Savineau JP, Crevel H, Marthan R
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mars 1995 Pflugers Archiv : European journal of physiology

Control of pulmonary vascular smooth muscle tone by sarcoplasmic reticulum Ca2+ pump blockers: thapsigargin and cyclopiazonic acid.

Auteurs : Gonzalez De La Fuente P, Savineau JP, Marthan R
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février 1995 Respiration physiology

Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries.

Auteurs : Savineau JP, Gonzalez de la Fuente P, Marthan R
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août 1994 The American journal of physiology

Human airway smooth muscle responsiveness in neonatal lung specimens.

Auteurs : Fayon M, Ben-Jebria A, Elleau C, Carles D, Demarquez JL, Savineau JP, Marthan R
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avril 1994 British journal of pharmacology

Diosmin-induced increase in sensitivity to Ca2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein.

Auteurs : Savineau JP, Marthan R
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février 1994 The Journal of physiology

Activation properties of chemically skinned fibres from human isolated bronchial smooth muscle.

Auteurs : Savineau JP, Marthan R
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février 1994 Muscle & nerve

Single fiber EMG and spectral analysis of surface EMG in myotonia congenita with or without transient weakness.

Auteurs : Lagueny A, Marthan R, Schuermans P, Le Collen P, Ferrer X, Julien J
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février 1994 American journal of respiratory and critical care medicine

Human bronchial smooth muscle responsiveness after in vitro exposure to acrolein.

Auteurs : Ben-Jebria A, Marthan R, Rossetti M, Savineau JP, Ultman JS
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janvier 1994 Revue des maladies respiratoires

[Mechanisms of bronchial hyperreactivity. Role of smooth muscle]

Auteurs : Marthan R, Stephens NL
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novembre 1993 European journal of pharmacology

Effect of vascular smooth muscle relaxants on the protein kinase C-mediated contraction in the rat pulmonary artery.

Auteurs : Savineau JP, Gonzalez De La Fuente P, Marthan R
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juillet 1993 Respiration physiology

Effect of in vitro exposure to acrolein on carbachol responses in rat trachealis muscle.

Auteurs : Ben-Jebria A, Marthan R, Rossetti M, Savineau JP, Ultman JS
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juillet 1993 The American review of respiratory disease

Sensitization decreases relaxation in human isolated airways.

Auteurs : Villanove X, Marthan R, Tunon de Lara JM, Johnson PR, Savineau JP, McKay KO, Alouan LA, Armour CL, Black JL
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mai 1993 British journal of pharmacology

Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIP.

Auteurs : Ben-Jebria A, Marthan R, Rossetti M, Savineau JP
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mars 1993 Pulmonary pharmacology

Effect of cromakalim on KCl-, noradrenaline- and angiotensin II-induced contractions in the rat pulmonary artery.

Auteurs : Savineau JP, Marthan R
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novembre 1992 Respiration physiology

Responsiveness to histamine in human sensitized airway smooth muscle.

Auteurs : Marthan R, Crevel H, Guénard H, Savineau JP
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août 1992 The American review of respiratory disease

Effect of in vitro nitrogen dioxide exposure on human bronchial smooth muscle response.

Auteurs : Ben-Jebria A, Marthan R, Savineau JP
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juillet 1992 Archives internationales de physiologie, de biochimie et de biophysique

[Cellular mechanism of muscle contraction of bronchial smooth muscle].

Auteurs : Marthan R
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mai 1992 The Journal of allergy and clinical immunology

The effect of sodium cromoglycate on platelets: an in vivo and in vitro approach.

Auteurs : Tunon-de-Lara JM, Rio P, Marthan R, Vuillemin L, Ducassou D, Taytard A
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avril 1992 Journal of neurology, neurosurgery, and psychiatry

Unilateral diaphragmatic paralysis: an electrophysiological study.

Auteurs : Lagueny A, Ellie E, Saintarailles J, Marthan R, Barat M, Julien J
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janvier 1992 Revue des maladies respiratoires

[A dyspnea of unusual cause in a chronic bronchitis patient]

Auteurs : Villanueva P, Tunon de Lara JM, Marthan R, Taytard A
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janvier 1992 Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

IgE binding inhibits arachidonic acid-induced chemiluminescence of human platelets.

Auteurs : Rio P, Tunon de Lara JM, Marthan R, Taytard A
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novembre 1991 British journal of pharmacology

Contraction of vascular smooth muscle induced by phorbol 12,13 dibutyrate in human and rat pulmonary arteries.

Auteurs : Savineau JP, Marthan R, Crevel H
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novembre 1989 The American review of respiratory disease

Is a myogenic response involved in deep inspiration-induced bronchoconstriction in asthmatics?

Auteurs : Marthan R, Woolcock AJ
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octobre 1989 The Journal of allergy and clinical immunology

Sensitization alters contractile responses and calcium influx in human airway smooth muscle.

Auteurs : Black JL, Marthan R, Armour CL, Johnson PR
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mai 1989 Journal of applied physiology (Bethesda, Md. : 1985)

Solubility of Freon 22 in human blood and lung tissue.

Auteurs : Varene N, Choukroun ML, Marthan R, Varene P
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avril 1989 Journal of applied physiology (Bethesda, Md. : 1985)

Calcium channel currents in isolated smooth muscle cells from human bronchus.

Auteurs : Marthan R, Martin C, Amédée T, Mironneau J
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janvier 1989 Revue des maladies respiratoires

[Calcium antagonists and chronic obstructive bronchopneumopathies]

Auteurs : Hilbert G, Marthan R, Vergeret J, Taytard A
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septembre 1988 Journal of autonomic pharmacology

Prostaglandin F2 alpha augments the response to parasympathetic fibre stimulation in an isolated innervated preparation of rabbit trachea.

Auteurs : Armour CL, Johnson PR, Marthan R, Black JL
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février 1988 Respiration physiology

Extracellular calcium and human isolated airway muscle: ionophore A23187 induced contraction.

Auteurs : Marthan R, Armour CL, Johnson PR, Black JL
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janvier 1988 Progress in clinical and biological research

Is airway hyperresponsiveness a smooth muscle abnormality?

Auteurs : Black J, Marthan R, Armour C, Johnson P
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février 1987 Respiration physiology

Acetylcholine-induced contraction in human isolated bronchial smooth muscle: role of an intracellular calcium store.

Auteurs : Marthan R, Savineau JP, Mironneau J
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janvier 1987 The American review of respiratory disease

The calcium channel agonist BAY K8644 enhances the responsiveness of human airway muscle to KCl and histamine but not to carbachol.

Auteurs : Marthan R, Armour CL, Johnson PR, Black JL
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avril 1985 Chest

Gas exchange alterations in patients with chronic obstructive lung disease.

Auteurs : Marthan R, Castaing Y, Manier G, Guenard H
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janvier 1985 Revue des maladies respiratoires

[The inert gas method in respiratory physiopathology]

Auteurs : Guenard H, Manier G, Castaing Y, Marthan R
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avril 1983 Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression

[A case of postoperative meningitis caused by 3 gram-negative bacteria]

Auteurs : Maurette P, Dabadie P, Stricker A, Marthan R, Chevais R
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